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From T-nation.com -
Grapefruit Juice and Supplements
Intestinal cytochrome P-450 is a busy little enzyme. It metabolizes an incredible number of the drugs we ingest.
If, however, you inhibit cytochrome P-450, it doesn't metabolize the drugs as well, resulting in higher concentrations of said drug.
Certain naturally occuring flavonoids and other chemicals inhibit cytochrome P-450, and they're found in high levels in broccoli, cabbage, spinach, onions, garlic, and parsley.
However, none contain higher amounts of these inhibitory enzymes than grapefruit juice, which can inhibit enzyme activity by as much as 84% (according to one study). In fact, many pharmacists will warn you not to take certain prescription items with grapefruit juice, as it may result in undesirably high levels of the drug.
However, if you're careful, grapefruit juice can be used with any number of supplements to either intensify the effect, or make the effect last longer.
While Biotest doesn't have lab information on all of the product ingredients that are metabolized by cytochrome P-450, the enzyme is surely involved in metabolizing forskolin and yohimbine.
Personally, I've found the effects of Carbolin 19, HOT-ROX Extreme, and, unless it's my imagination, Spike, to be intensified by taking them with 8 ounces of grapefruit juice.
If you try it, use a whole lot of caution!
Grapefruit Juice and Supplements
Intestinal cytochrome P-450 is a busy little enzyme. It metabolizes an incredible number of the drugs we ingest.
If, however, you inhibit cytochrome P-450, it doesn't metabolize the drugs as well, resulting in higher concentrations of said drug.
Certain naturally occuring flavonoids and other chemicals inhibit cytochrome P-450, and they're found in high levels in broccoli, cabbage, spinach, onions, garlic, and parsley.
However, none contain higher amounts of these inhibitory enzymes than grapefruit juice, which can inhibit enzyme activity by as much as 84% (according to one study). In fact, many pharmacists will warn you not to take certain prescription items with grapefruit juice, as it may result in undesirably high levels of the drug.
However, if you're careful, grapefruit juice can be used with any number of supplements to either intensify the effect, or make the effect last longer.
While Biotest doesn't have lab information on all of the product ingredients that are metabolized by cytochrome P-450, the enzyme is surely involved in metabolizing forskolin and yohimbine.
Personally, I've found the effects of Carbolin 19, HOT-ROX Extreme, and, unless it's my imagination, Spike, to be intensified by taking them with 8 ounces of grapefruit juice.
If you try it, use a whole lot of caution!
