FOX04-DRI Peptide to Remove Senescent Cells

[pegasus2]

Anyone else want to try this?

$5000 for 1 gram in ten mg vials. One round of treatment is about 100mg, so that's $500 for ten people. It won't do anything for hair by itself, but I could see it improving the efficacy of other treatments by clearing out senescent cells. There are a lot of them in balding scalp, and that's a big roadblock. I'll probably just spend the $900 to get 100mg tomorrow, but let's see how much interest there is.

https://patents.google.com/patent/WO2016118014A2/en

FOXO4, Anti-Aging and Hair Growth | Hair Loss Cure 2020

FOXO4 is linked to anti-aging and hair growth. In particular, through senescent cell destruction via Dr. Peter de Keizer's FOXO4-DRI peptide.

www.hairlosscure2020.com

 

[HairOnFire]

Anyone else want to try this?

$5000 for 1 gram in ten mg vials. One round of treatment is about 100mg, so that's $500 for ten people. It won't do anything for hair by itself, but I could see it improving the efficacy of other treatments by clearing out senescent cells. There are a lot of them in balding scalp, and that's a big roadblock. I'll probably just spend the $900 to get 100mg tomorrow, but let's see how much interest there is.

FOXO4, Anti-Aging and Hair Growth | Hair Loss Cure 2020

FOXO4 is linked to anti-aging and hair growth. In particular, through senescent cell destruction via Dr. Peter de Keizer's FOXO4-DRI peptide.

www.hairlosscure2020.com

Speaking of this, I believe someone posted the following abstract at some point:

Front Cell Dev Biol 2020 Oct 15;8:566617. doi: 10.3389/fcell.2020.566617. eCollection 2020.

Fisetin Promotes Hair Growth by Augmenting TERT Expression​

A quick search also shows that Fisetin is a potent senolytic. It's also available over-the-counter, in supplement form, and is reasonably priced, IIRC. For senolytic purposes, I believe the protocol is to use Fisetin orally for 2 consecutive days, then take a month off, and use it for 2 more consecutive days, and then you are done.

 

[pegasus2]

Speaking of this, I believe someone posted the following abstract at some point:

Front Cell Dev Biol 2020 Oct 15;8:566617. doi: 10.3389/fcell.2020.566617. eCollection 2020.

Fisetin Promotes Hair Growth by Augmenting TERT Expression​

A quick search also shows that Fisetin is a potent senolytic. It's also available over-the-counter, in supplement form, and is reasonably priced, IIRC. For senolytic purposes, I believe the protocol is to use Fisetin orally for 2 consecutive days, then take a month off, and use it for 2 more consecutive days, and then you are done.

I did get some fisetin to go with it. They seem to be the two best senolytics available thus far. I'm excited about the next version of FOX04-DRI, it's supposed to be 100 times more potent. The problem is it only targets IL-6 positive cells. That's why I'm using fisetin too. I'll do 3-5g for four or five days, and that's it. Taking it along with quercetin might improve availability.

 

[-G-]

Where will you be purchasing it from?

 

[BetaBoy]

Cellular senescence plays zero part in AGAs progression it doesn’t even play much of a role in hairloss in very old people either. Total waste of money when there are more promising peptides out there that are a hell of a lot cheaper.

 

[pegasus2]

Cellular senescence plays zero part in AGAs progression it doesn’t even play much of a role in hairloss in very old people either. Total waste of money when there are more promising peptides out there that are a hell of a lot cheaper.

Did I say it did? Actually I said it didn't. However, the senescent cells after hair loss takes place do alter cell metabolism, and prevent proliferation of healthy cells. Senescent cells might prevent regrowth. But if you have any better ideas I'd like to hear about these other peptides. Maybe you know of a good one that I'm not yet using. If this is a lot of money to you then don't buy it. I'm not suggesting it's some kind of cure.

 

[BetaBoy]

Did I say it did? Actually I said it didn't. However, the senescent cells after hair loss takes place do alter cell metabolism, and prevent proliferation of healthy cells. Senescent cells might prevent regrowth. But if you have any better ideas I'd like to hear about these other peptides. Maybe you know of a good one that I'm not yet using. If this is a lot of money to you then don't buy it. I'm not suggesting it's some kind of cure.

Cellular senescence isn’t the reason hfcs aren’t able to proliferate after catagen, most hairloss occurs decades before cellular senescence begins to take hold.

f*** me you’re on a lot of stuff but I don’t see MK-677, it increases the production of IGF-1 which is a known promoter of hair growth.

 

[pegasus2]

Cellular senescence isn’t the reason hfcs aren’t able to proliferate after catagen, most hairloss occurs decades before cellular senescence begins to take hold.

f*** me you’re on a lot of stuff but I don’t see MK-677, it increases the production of IGF-1 which is a known promoter of hair growth.

Cellular senescence takes hold immediately in balding scalp, and there are lots of reasons they don't proliferate, this is just one.

Thanks, but I think I have IGF1 covered pretty well already.

 

[BetaBoy]

Cellular senescence takes hold immediately in balding scalp, and there are lots of reasons they don't proliferate, this is just one.

Thanks, but I think I have IGF1 covered pretty well already.

That sounds highly speculative.

 

[FollicleGuardian]

That sounds highly speculative.

Without speculation we aren’t getting anywhere though

 

[pegasus2]

That sounds highly speculative.

https://www.jdsjournal.com/article/S0923-1811(17)30026-9/fulltext

Speculation is how progress is made

 

[bags]

Go To: 21:16

Dude uses Fox04 Dri a little later on in the Doctor, this wife comments how is hair is looking much better although Im not seeing any miracles here... let alone the fact hes not that bad....

Bet F04 is amazing at reversing every fkked up cell in the body minus hair.... I personally think in nature, before we got all sophisticated thinking we know better..... humans were meant to look their best and be their most virile at puberty.... into their late teens at start falling apart at 21.

From an evolutionary stand point for the survival of our species to be the most robust it can be, it only makes sense. Young fertile girls are not looking to bald headed dudes to reproduce... maybe thats why its seems so impossible to fix this seemingly simple problem of balding. Maybe nature has made the hair follicle on the top of the head the most complex sh!t imaginable to the point DeepMind wont ever solve it.....

Today with anabolics and androgens, soceity has created a "new look". The bald dudes who are jacked to the gills. That basically gives baldies 1 angle to work in their favor. Youre not going to bag the young fertile ones with that look, but you can defo bag some fine *** poon in their 30s+. If you got money then early 20s is an option.....

TL: DR just watch the video and ignore the ramblings.....

 

[pegasus2]

Worst shot I've ever had. I got an instant reaction from it same as Darren.

 

[Squeegee 2.0]

Cellular senescence plays zero part in AGAs progression it doesn’t even play much of a role in hairloss in very old people either. Total waste of money when there are more promising peptides out there that are a hell of a lot cheaper.

Androgen receptor drives cellular senescence​

Androgen receptor drives cellular senescence - PubMed

The accepted androgen receptor (AR) role is to promote proliferation and survival of prostate epithelium and thus prostate cancer progression. While growth-inhibitory, tumor-suppressive AR effects have also been documented, the underlying mechanisms are poorly understood. Here, we for the first...

pubmed.ncbi.nlm.nih.gov

Induction of androgen-accelerated premature senescence (loss of proliferative capacity) in bald scalp dermal papilla cells of Androgenetic Alopecia patients is one more fragment of the pathway.

Chapter: Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

Signaling pathways that control coordination of hair follicle cells genetic program are the convenient model for explaining the hierarchy of intercellular interactions governing cyclic growth of hair.

www.intechopen.com

 

[Gegen]

Worst shot I've ever had. I got an instant reaction from it same as Darren.

Lol with all the experimental medications you use one day your scalp will do a spontaneous combustion. Do you think you will continue FOX04 after this reaction ?

 

[FollicleGuardian]

Yes, it's only 5 injections.

Injections in the scalp? You use mesogun?

 

[Chads don't bald]

When it comes to senolytics, there are companies like Oisin Biotechnology attempting to use gene therapy for an effective and targeted approach which should be much superior to any current senolytics on the market.

This is for aging, but it could help with hair loss as well if it eliminates all senescent cells in the body. Just something to keep track of. A lot of non-hair loss related approaches may end up helping with hair loss in the future as we learn to rejuvenate the human body.

After all, finasteride wasn't even a hair loss drug at first.