Got blood tests done to check avodart effect

global

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I've been on avodart 0.5mg/day since August 2003 and before that I was on propecia for about 2.5 years. I'm 39 years old.

I decided to get some blood tests done to see what is going on with my hormones, here's the results -

First, liver etc all ok.

DHT - 0.62 nmol/l normal range 1.13 - 4.13
Testosterone 16.5 nmol/l normal range 9.9 - 27.8
Estrogen (17 beta estradiol) 88 pmol/l normal range 44 - 146

Basically everything is OK, I hope this helps some of you who may be worried about the effects of dutasteride.
 

tomas99

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If liver is OK and side effects does not show up, it is OK. But I suppose that not everyone on his forum is having regular blood tests, especially if they are using generic Finasteride.

Do you remember how was your Estradiol in last or first blood test? I would really like to know how finasteride/dutasteride affects Estrogen levels. Any idea of your Prolactin levels?
 

antonio666

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global,thanks for putting your results on the forum,in percentage do you know how much DHT is being eliminated
 

Nick4441

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This is great to see test results. Is it what you thought?

DHT is nicely lower but would have expected it to be even lower than the figures.

Are you on generic or real?..sounds like its working if your loss is stopped.

Interested to see what Brian and College think of the results.
 

global

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I use genuine GSK avodart.

I'd like to be able to say I had blood tests done before starting on the dutasteride to see how things have changed but I didn't so unfortunately I can't make before/after comparisons.

Nick, regarding DHT being even lower I suppose it depends on what my DHT was before starting but yes you are right, since dutasteride is supposed to reduce serum DHT by 90% then it should be even lower.

I any case so far it's working for me as my loss seems to have halted since starting dutasteride.
 

Nick4441

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Its good news its working for you.

After 7 months on finasteride I have started dutasteride this week. I'm just looking to halt loss, Propecia never did anything for me and I have lost hair rapidy while taking it.

There does seem to be many successes with dutasteride where Propecia has failed so a few of us moving over to dutasteride hoping to get some results.

It is much more powerful so hoping I don't get sides, I had to cut my Propecia dose because of sides. You are obviously not suffering sides or minimal sides.

Where do you get yours..genuine is expensive so I went for Dutas from UP.
 

Harie

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Global - how old are you? Will help to put your test/estrogen results into a better light. I mean, if you're 50, then those are great levels. If you're 20, they're just ok.

And are you still waiting for regrowth from your hair transplant?
 

CCS

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he said he is 39.

as for DHT, maybe he produces more DHT naturally, so he would have been above average had he not been a dutasteride. But there are a lot of bald/hairy/big prostate men out there.
 

Harie

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collegechemistrystudent said:
he said he is 39.

Oh, duh, didn't see that the 1st time. I'm an idiot.

Your levels are just fine then Global.
 

RaginDemon

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good to see the results.

I am glad treatments are working for you!
 

bombscience

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Global - what test did you ask for exactly? I'd like to have the same done. I asked my doctor last time and she wasn't sure of what I was asking for? Maybe I need a new doctor?
 

global

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Nick4441 said:
Its good news its working for you.

After 7 months on finasteride I have started dutasteride this week. I'm just looking to halt loss, Propecia never did anything for me and I have lost hair rapidy while taking it.

There does seem to be many successes with dutasteride where Propecia has failed so a few of us moving over to dutasteride hoping to get some results.

It is much more powerful so hoping I don't get sides, I had to cut my Propecia dose because of sides. You are obviously not suffering sides or minimal sides.

Where do you get yours..genuine is expensive so I went for Dutas from UP.

I get mine from http://www.qhi.co.uk - much cheaper than UP.
 

global

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Harie said:
Global - how old are you? Will help to put your test/estrogen results into a better light. I mean, if you're 50, then those are great levels. If you're 20, they're just ok.

And are you still waiting for regrowth from your hair transplant?

Hi, I'm 39.

I had my transplant almost exactly a year ago (I had my temples filled in) and I'd say its fully grown in now, although I think the hair is still continuing to improve in quality, i.e getting thicker and straighter.
 

global

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bombscience said:
Global - what test did you ask for exactly? I'd like to have the same done. I asked my doctor last time and she wasn't sure of what I was asking for? Maybe I need a new doctor?

I just said I wanted my testosterone, estrogen and DHT levels checked along with a standard liver panel and full blood count.

If your Doctor can't understand that then I'd say yes, definitely time to get a new Doctor!!
 

Old Baldy

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Interesting Global. If your DHT levels were reduced, by let's say 92 percent, you had a DHT level of roughly 7.75 before taking dutasteride.

That's out of the normal range by quite a bit. Tells me something about us male pattern baldness sufferers! :-x

Your testosterone levels were probably at the lower end of the acceptable range also? Hmmm....?

Less testosterone, more DHT? Hmmm....?

Friggin" male pattern baldness!! :cry:

I want my testosterone back!! :-x

Harie, why wouldn't he want the testosterone level of a 25 year old rather than the normal level of a 39 year old? :wink:

Tidbit quote from Dr. Sahelian regarding declining levels of testosterone in men nowadays. (Could this be why men are experiencing more male pattern baldness at younger ages?):

Testosterone levels lower in men
There has been a drop in U.S. men's testosterone levels since the 1980s. The average testosterone level dropped by 1 percent a year, Dr. Thomas Travison and colleagues from the New England Research Institutes in Watertown, Massachusetts, found. This means that, for example, a 65-year-old man in 2002 would have testosterone levels 15 percent lower than those of a 65-year-old in 1987. This also means that a greater proportion of men in 2002 would have had below-normal testosterone levels than in 1987. Travison and his team analyzed data from the Massachusetts Male Aging Study, a long-term investigation of aging in about 1,700 Boston-area men. Data from the men were collected for three time intervals: 1987-1989, 1995-1997, and 2002-2004. While a man's testosterone level will fall steadily as he ages, the researchers observed a speedier decline in average testosterone levels than would have been expected with aging alone. They hypothesized that the rising prevalence of obesity as well as the sharp decline in cigarette smoking might help explain their findings, given that testosterone levels are lower among overweight people and smoking increases testosterone levels. But these factors accounted for only a small percentage of the observed difference. It's likely that some sort of environmental exposure is responsible for the testosterone decline. Journal of Clinical Endocrinology and Metabolism, January 2007

Of course, I'm assuming your body compensates by producing more DHT. This is an opinion by a total layman though!!

Nope, I"M WRONG:

102. Transdermal testosterone therapy in the treatment of male hypogonadism.
Ahmed SR, Boucher AE, Manni A, Santen RJ, Bartholomew M, Demers LM
Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
J Clin Endocrinol Metab 1988 Mar;66(3):546-51

Five hypogonadal men were treated with transdermal testosterone therapy, using a testosterone patch applied to the scrotal skin. Daily application of the patch, which contained 10 mg testosterone, produced an increase in serum testosterone concentrations from a pretreatment value of 45 +/- 12 (+/- SE; 1.5 +/- 0.4) to 436 +/- 80 ng/dL (15.1 +/- 2.8 nmol/L; P less than 0.001) after 4 weeks of treatment. Normal serum testosterone concentrations were achieved in all men after 6-8 weeks of therapy and were maintained during continued long term therapy for 9-12 months with a patch containing 15 mg testosterone. All men reported a subjective increase in libido and sexual function during therapy, and three men preferred it to testosterone injections. The serum testosterone and estradiol levels did not rise above the normal adult male range at any time during therapy. However, elevated serum dihydrotestosterone (DHT) concentrations occurred during treatment; the pretreatment DHT concentration was 95 +/- 3 ng/dL (3.3 +/- 0.1 nmol/L), and it increased to 228 +/- 40 ng/dL (7.8 +/- 1.4 nmol/L) after 4 weeks of treatment and remained elevated thereafter. The individual mean DHT to testosterone ratio increased from a pretreatment value of 0.2 (range, 0.1-0.3) to 0.6 (range, 0.4-0.7) after 2 weeks of therapy and remained high thereafter. Comparison of the serum DHT levels in patients during therapy with those in normal men who had similar testosterone concentrations [531 +/- 62 vs. 566 +/- 72 ng/dL (18.4 +/- 2.1 vs. 19.6 +/- 2.5 nmol/L); P greater than 0.05] revealed that the mean serum DHT concentration was significantly higher in the patients [315 +/- 69 vs. 87 +/- 6 ng/dL (10.8 +/- 2.4 vs. 2.9 +/- 0.2 nmol/L); P less than 0.001], as was the mean DHT to testosterone ratio [0.6 (range, 0.25- 1.1) vs. 0.16 (range, 0.09- 0.24); P less than 0.001]. The high serum DHT levels presumably were due to increased metabolism of testosterone to DHT by the 5 alpha-reductase in the scrotal skin. Serum 3 alpha-androstanediol glucuronide levels were not elevated in the patients. We conclude that transdermal testosterone therapy is an effective long term treatment for hypogonadism in men. It is, however, associated with high serum DHT levels, whose potential long term effects on the prostate and other tissues need to be investigated.

Another wacko Old Baldy, layman theory put to rest!! :oops: :oops: :2gunsfiring_v1:

Friggin' male pattern baldness. God da**it!!!
 
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