GP4G stimulates human hair follicle cells metabolism and..

[Jacob]

..growth in organ culture. (Any way to allow longer Subject titles??

http://gruppo-ortodermico.it/documenti/PF Hair Care GP4G.pdf

Treated cells with GP4G
display more oxygen
consumption than control
without serum. The % of
increase of oxygen
consumption related to the negative control is about +40% and +100% in the presence
of GP4G at 1% and 5% respectively.
n Hair growth ex vivo :
Ex vivo, the hair grow faster in the presence of GP4G at 5%.
The mean rate at day 6/day0 was +110% for treated follicles with GP4G vs +17% for
control follicles, +36% for minoxidil group and +20% for the group treated with
a-tocopherol nicotinate.

The basics:
http://www.ehrs.org/conferenceabstracts/2004berlin/researchabstracts/P10-134-Lachgar.htm

P10.134 GP4G stimulates human hair follicle cells metabolism and growth in organ culture

S. Lachgar, L.Fort-Lacoste, V.Ermosilla, M.Charvéron

European Research Center on skin, IRPF, Hôtel-dieu Saint Jacques Hospital, Toulouse, France

GP4G, or diguanosine-tetra-phosphate, a molecule extracted from zoo-plankton, is considered a precursor of ATP, and described to activate G protein in skin.

The aim of this study was to check whether this molecule can stimulate the metabolism of hair dermal papilla cells in vitro and hair growth ex vivo.

Anagen hair follicles were micro-dissected from the occipital region of the human scalp. Dermal papilla cells were isolated from these follicles and cultured. The effect of GP4G on cell metabolism was assessed by O2 consumption.

Hair follicles in organ culture were treated with GP4G at 5%, ?-tocopherol-nicotinate at 100µg/ml or 24µM Minoxidil. Growth was measured during 9 days.

GP4G increased the proliferation and the oxygen consumption of cultured hair dermal papilla cells in a dose responsive manner. The % of increase of oxygen consumption compared to the control was about +40% and +100% in the presence of 1% and 5% GP4G, respectively.

Ex vivo, hair grew faster in the presence of GP4G at 5%. The mean growth rate at day 6/day0 was +110% for treated follicles with GP4G vs +17% for control follicles, +36% for minoxidil group and +20% for the group treated with ?-tocopherol nicotinate.

The ability of GP4G to stimulate the metabolism of hair follicle cells in vitro and hair growth ex vivo demonstrates that hair follicles maintained in organ culture are able to respond to this metabolic promoter.

A few product lines I came across that contain it:
http://www.trichovedic.com.au/our-products/follicle-stimulation-programme-for-senescent-hair-loss/

http://froika.com/default.asp?V_DOC_ID=2128

http://www.tecnaprofessional.eu/2009/en/products/hair-loss-treatment.html

 

[jonson]

Is it stronger than minoxidil?

 

[DavisNY]

any word if this has any sides?

 

[Jacob]

Is it stronger than minoxidil?

I think the correct answer to that is- probably for some. They seem to be implying it is..but you know how that goes. And minoxidil doesn't do much for many...sometimes other things do.

 

[Jacob]

any word if this has any sides?

None mentioned..but :dunno:

 

[Jacob]

Got a very fast reply from these guys http://www.trichovedic.com.au/our-products/follicle-stimulation-programme-for-senescent-hair-loss/ on the ingredients list:

Alcohol Denat,

Aqua,

Serenoa Serrulata Fruit Extract (Saw Palmetto),

PEG-40 Hydrogenated Castor Oil,

Polysorbate 80,

Urtica Dioica (Nettle) Extract,

Malaleuca Alternifolia (Tea Tree) Leaf Oil,

Glycerin,

Artemia (Plankton) Extract (GP4G),

Tocpheryl Extract,

2-4 Diaminopyrimidine-3-Oxide( Kopexil),

Caffeine,

Vitis Vinifera (Grape) Seed Extract,

Panthenol,

Oleic Acid,

Centella Asiatica (Gotu Kola) Extract,

Camellia Sinensis (Green Tea) Extract,

Hydrolyzed Soy Protein,

Rosmarinus Officinalis (Rosemary ) Oil,

Lactic Acid,

Tussilago Farfara (Coltsfoot) Leaf Extract,

Achillea Millefolium (Yarrow) Extract,

Salvia Officinalis (Sage) Leaf Extract,

Betula Alba (White Birch) Juice,

Betula Alba (White Birch) Leaf Extract,

Equisetum Arvense (Horsetail) Extract.

 

[2020]

if this really worked as advertised, then im sure it wouldve been more popular...
30% increase...wow :innocent:

 

[Jacob]

Well I'm not sure how long it's/they've been out..but yeah, you can say that about ANYthing. Nothing out there is working miracles. A lot of these things you can't even find testimonials on. Others you'll see some but the ppl don't stick with it. Etc etc.

I don't see them saying it'll grow more hair than any other agent..that it's the OBVIOUS choice..that there are "mysterious ingredients" that we can't divulge... :woot: Sorry..couldn't help myself. I just can't get over that going on..for 15+ years :shakehead:

 

[jonson]

Kopexil and aminexil is same thing?

 

[Berserk]

Sorry to bump this thread, but this GP4G seems interesting. I had a question, though: what does it mean when it is supposed to activate G protein in skin? Would that be dangerous in anyway? Thanks for any information you can provide.