Serpico
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It seems like there has been some progression in our understanding of green tea and ECGC over the last 15 years.
Soy Phytochemicals and Tea Bioactive Components Synergistically Inhibit Androgen-Sensitive Human Prostate Tumors in Mice
Jin-Rong Zhou Lunyin Yu Ying ZhongGeorge L. Blackburn
Green tea did not reduce final tumor weight, although it tended to elevate (P = 0.14) the serum dihydrotestosterone (DHT) concentration. The combination of SPC and black tea synergistically inhibited prostate tumorigenicity, final tumor weight and metastases to lymph nodes in vivo. The combination of SPC and green tea synergistically inhibited final tumor weight and metastasis and significantly reduced serum concentrations of both testosterone and DHT in vivo.
Oh no! DHT! But wait a sec, yes, you're right. This study is over 15 years old. George W. Bush was just starting his presidency. Our understanding has fortunately progressed since then. Just step back and ask your self some common sense questions to see the forest from the trees.
Yes it may increase DHT, but it is also reducing tumorogenicity. How can this be? Doesn't DHT increase prostate cancer? We like thinking like engineers, but physiology is not binary. In the absence of evidence, we must reason by first principles and analogy. In that context, I would suggest that if it's good at fighting androgen sensitive prostate cancer, probably good for hair. Bullshit you say. Show me the mechanism you say. I'm glad you asked.
Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer
Imtiaz A. Siddiqui,1 Mohammad Asim,1,2 Bilal B. Hafeez, Vaqar M. Adhami, Rohinton S. Tarapore, and Hasan Mukhtar3
During the past decade, a number of studies demonstrated potential effects of tea polyphenols, including EGCG, through multiple mechanisms, including cell growth inhibition (48–50), induction of apoptosis (50, 51), cell cycle arrest (51), inhibition of type 2,5-α-reductase (49), and in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase (52).
Still not convinced? These are prostate cancers. Humans are not furry mice (Robin Williams was a bear, not a mouse). Well you called me out. But I still got a few cards up my sleeve. Let's look at the dermal papilla then, the semi-mythical source of all hair. Local expression of DHT is far more important than blood levels. Not blood DHT, but microRNA DHT expression. Local effects trump blood levels.
Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells.
Shin S1, Kim K1, Lee MJ1, Lee J1, Choi S1, Kim KS1, Ko JM1, Han H1, Kim SY1, Youn HJ2, Ahn KJ2, An IS3, An S1, Cha HJ1.
EGCG protected against the effects of DHT by altering the miRNA expression profile in human DPCs. In addition, EGCG attenuated DHT-mediated cell death and growth arrest and decreased intracellular ROS levels and senescence.
Need an in vivo study? Well all I got is an animal model. But in the context of above, it's results are consistent.
Effects of topical application of EGCG on testosterone-induced hair loss in a mouse model.
Kim YY, Up No S, Kim MH, Kim HS, Kang H, Kim HO, Park YM.
We investigated the effect of topical epigallocatechin-3-gallate (EGCG) on testosterone (T)-induced hair loss in mice. Marked hair loss was observed at the T-injected site, and topical EGCG significantly reduced the hair loss (P < 0.05).
The effects of tea polyphenolic compounds on hair loss among rodents.
The results showed that 33% of the mice in experimental Group A, who received polyphenol extract in their drinking water, had significant hair regrowth during six months of treatment (p = 0.014). No hair growth was observed among mice in the control group, which received regular water.
It dries up my sebaceous glands, induces autophagy when I'm fasting and keeps me level. There is unlikely to be a quality peer reviewed double blinded clinical trial on this because that would destroy the budget of any reputable researcher to conduct unless funded by big pharma (hair loss will never make as much money as chemo/heart disease because of reimbursement schema from the Policy & Steering committee in Washington), and the NIH rarely funds dietary studies. For the time being I'm going to continue my matcha. Actually could use a cup right now.
Also, if you're on finasteride/dutasteride, you sure as truck better be worried about androgen insensitive prostate cancer down the line. Prevention is far easier than treatment.
Would love to hear thoughts.
Soy Phytochemicals and Tea Bioactive Components Synergistically Inhibit Androgen-Sensitive Human Prostate Tumors in Mice
Jin-Rong Zhou Lunyin Yu Ying ZhongGeorge L. Blackburn
Green tea did not reduce final tumor weight, although it tended to elevate (P = 0.14) the serum dihydrotestosterone (DHT) concentration. The combination of SPC and black tea synergistically inhibited prostate tumorigenicity, final tumor weight and metastases to lymph nodes in vivo. The combination of SPC and green tea synergistically inhibited final tumor weight and metastasis and significantly reduced serum concentrations of both testosterone and DHT in vivo.
Oh no! DHT! But wait a sec, yes, you're right. This study is over 15 years old. George W. Bush was just starting his presidency. Our understanding has fortunately progressed since then. Just step back and ask your self some common sense questions to see the forest from the trees.
Yes it may increase DHT, but it is also reducing tumorogenicity. How can this be? Doesn't DHT increase prostate cancer? We like thinking like engineers, but physiology is not binary. In the absence of evidence, we must reason by first principles and analogy. In that context, I would suggest that if it's good at fighting androgen sensitive prostate cancer, probably good for hair. Bullshit you say. Show me the mechanism you say. I'm glad you asked.
Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer
Imtiaz A. Siddiqui,1 Mohammad Asim,1,2 Bilal B. Hafeez, Vaqar M. Adhami, Rohinton S. Tarapore, and Hasan Mukhtar3
During the past decade, a number of studies demonstrated potential effects of tea polyphenols, including EGCG, through multiple mechanisms, including cell growth inhibition (48–50), induction of apoptosis (50, 51), cell cycle arrest (51), inhibition of type 2,5-α-reductase (49), and in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase (52).
Still not convinced? These are prostate cancers. Humans are not furry mice (Robin Williams was a bear, not a mouse). Well you called me out. But I still got a few cards up my sleeve. Let's look at the dermal papilla then, the semi-mythical source of all hair. Local expression of DHT is far more important than blood levels. Not blood DHT, but microRNA DHT expression. Local effects trump blood levels.
Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells.
Shin S1, Kim K1, Lee MJ1, Lee J1, Choi S1, Kim KS1, Ko JM1, Han H1, Kim SY1, Youn HJ2, Ahn KJ2, An IS3, An S1, Cha HJ1.
EGCG protected against the effects of DHT by altering the miRNA expression profile in human DPCs. In addition, EGCG attenuated DHT-mediated cell death and growth arrest and decreased intracellular ROS levels and senescence.
Need an in vivo study? Well all I got is an animal model. But in the context of above, it's results are consistent.
Effects of topical application of EGCG on testosterone-induced hair loss in a mouse model.
Kim YY, Up No S, Kim MH, Kim HS, Kang H, Kim HO, Park YM.
We investigated the effect of topical epigallocatechin-3-gallate (EGCG) on testosterone (T)-induced hair loss in mice. Marked hair loss was observed at the T-injected site, and topical EGCG significantly reduced the hair loss (P < 0.05).
The effects of tea polyphenolic compounds on hair loss among rodents.
The results showed that 33% of the mice in experimental Group A, who received polyphenol extract in their drinking water, had significant hair regrowth during six months of treatment (p = 0.014). No hair growth was observed among mice in the control group, which received regular water.
It dries up my sebaceous glands, induces autophagy when I'm fasting and keeps me level. There is unlikely to be a quality peer reviewed double blinded clinical trial on this because that would destroy the budget of any reputable researcher to conduct unless funded by big pharma (hair loss will never make as much money as chemo/heart disease because of reimbursement schema from the Policy & Steering committee in Washington), and the NIH rarely funds dietary studies. For the time being I'm going to continue my matcha. Actually could use a cup right now.
Also, if you're on finasteride/dutasteride, you sure as truck better be worried about androgen insensitive prostate cancer down the line. Prevention is far easier than treatment.
Would love to hear thoughts.
