Gut Bacteria, This May Be Old News But Figure A Discussion Is Worthy

[GG66]

I for one notice a major difference with diet and hair loss curious to know how big of a part this plays
So much of our appearance is directly related to gut health
Lactobacillus murinus may be the culprit
https://www.ncbi.nlm.nih.gov/m/pubmed/28813664/

 

[INT]

Mice study + not about alopecia androgenetica.

 

[Throwaway94]

I for one notice a major difference with diet and hair loss curious to know how big of a part this plays
So much of our appearance is directly related to gut health
Lactobacillus murinus may be the culprit
https://www.ncbi.nlm.nih.gov/m/pubmed/28813664/

Do you not realise what murinus means

 

[sktboiboi]

Sorry to put u down, but if anything, lactate worsens Androgenetic Alopecia in vivo becauze it increases malassezia profileration. Therez an article that showed the following are FOOD for Malassezia:

Sodium chloride(table salt)
Lactate/lactic acid
Pàlmitate/palmitic acid
Oleic acid(olive oil. Researches atually GROW malassezia cultures in the lab using this)

 

[sktboiboi]

Effects of compounds of sweat and free fatty acids
on growth
The effects on growth of sodium chloride, lactic acid and urea are
shown in Figure 2. Sodium chloride at 1% increased significantly
the growth rate of M. globosa, although it decreased that of M. sym-
podialis. Sodium chloride at 0.1% also increased the growth of
M. globosa. Lactic acid at 1% increased the growth rate of M. glob-
osa, but decreased that of M. sympodialis. Lactic acid at 0.1%
increased growth in M. globosa and M. sympodialis. Urea
decreased the growth of all Malassezia species at 1%, and that of
M. globosa, M. dermatis and M. furfur at 0.1%.
The effects on growth of lauric acid (C12), myristic acid (C14),
palmitic acid (C16), palmitoleic acid (C16:1), stearic acid (C18), oleic




18 In our study, sodium chloride at 1% and lactic acid at
0.1% significantly increased the growth rate of M. globosa, although
urea at 0.1% did not. This result indicates that sweat strongly pro-
motes the growth of M. globosa. In other words, M. globosa growth
tends to increase under summer conditions when temperatures are
high and people sweat. MF tends to be more prevalent in the sum-
mer months and in tropical locations than in temperate regions.13
Moreover, we confirmed that the number of M. globosa counted by
the culture method in healthy subjects tended to increase in sum-
mer.9 This characteristic of M. globosa may relate to the pathogene-
sis of MF.






Globosa =dandruff causing antigen

 

[sktboiboi]

Abstract
Dandruff and seborrheic dermatitis (D/SD) share an etiology dependent upon three factors: sebum, microbial metabolism (specifically, Malassezia yeasts), and individual susceptibility. Advances in microbiological and analytical techniques permit a more detailed understanding of these etiologic factors, especially the role of Malassezia. Malassezia are lipid-dependent and demonstrate adaptation allowing them to exploit a narrow niche on sebum-rich skin. Work in our and our collaborators' laboratories has focused on understanding these adaptations by detailed analysis of biochemistry and gene expression. We have shown that Malassezia globosa and M. restricta predominate on dandruff scalp, that oleic acid alone can initiate dandruff-like desquamation, that M. globosa is the most likely initiating organism by virtue of its high lipase activity, and that an M. globosa lipase is expressed on human scalp. Considering the importance of M. globosa in D/SD (and the overall importance of commensal fungi), we have sequenced the M. globosa and M. restricta genomes. Genomic analysis indicates key adaptations to the skin environment, several of which yield important clues to the role Malassezia play in human disease. This work offers the promise of defining new treatments to D/SD that are targeted at changing the level or activities of Malassezia genes.

 

[sktboiboi]

However i do agree that the gut microbiome is a causative factor for Androgenetic Alopecia.


Lactobacilus is 1 of them.

 

[Otis Mack]

Pet hypothesis- the gut permeability is changed by what we eat. The gram - bacteria in our intestines allow for LPS to enter into our blood stream. Some of this gets buffered out but some just get by.

Lipopolysacchrarides are what researchers use to create inflammation. I think the LIPO-polysaccharides end up in sebum which is made up of lipids. You have a potential reason why there could be inflammation around the bulge area(stem cell niche) which is by the sebaceous gland.

Human sebum is a known depilatory when applied on animals.

http://sci-hub.tw/10.1001/archderm.1953.01540010005001


It is what it is. I dont know how much this applies to human Androgenetic Alopecia or not. It would have been better if they took balding men's sebum and applied it to human test subjects.

 

[Otis Mack]

Can LPS fragments make it's way into sebum you ask?

https://www.ncbi.nlm.nih.gov/pubmed/16797202

https://selfhacked.com/blog/lipopolysaccharides/

Look at #5

5) Excessive Alcohol Intake
Acute binge drinking and chronic alcohol intake increase systemic LPS levels [33, 34].

Increased intestinal permeability (leaky gut) and higher circulating LPS levels were observed in a study of 54 patients with chronic alcohol abuse [35].

However, compared to nondrinkers, moderate alcohol consumption was associated with lower LPS levels in a study of 922 adults [36].




https://www.ncbi.nlm.nih.gov/pubmed/?term=twins+hair+caffeine+alcohol


RESULTS:
Increased smoking duration (p < 0.001) and the presence of dandruff (p = 0.028) were significantly associated with increased frontal hair loss. Increased exercise duration (p = 0.002),

consumption of more than four alcoholic drinks per week (p = 0.042),


and increased money spent on hair loss products (p = 0.050) were all associated with increased temporal hair loss.




Daily hat use (p = 0.050), higher body mass index (p = 0.012), and higher testosterone levels (p = 0.040) were associated with decreased temporal hair loss.

Factors that were significantly associated with increased vertex hair loss included abstinence from alcohol consumption (p = 0.030), consumption of more than four alcoholic drinks per week (p = 0.004),

(somewhere between 0-4 drinks per week would be ideal)


increased smoking duration (p = 0.047), increased exercise duration (p = 0.050), and increased stress duration (p = 0.010). Lower body mass index, more children, increased caffeine consumption, history of skin disease, and abstinence from alcohol were significantly associated with increased hair thinning scores (p < 0.05).

 

[Otis Mack]

PCOS(women) is thought to be close to male Androgenetic Alopecia.

https://www.ncbi.nlm.nih.gov/pubmed/22543078


This novel paradigm in PCOS aetiology suggests that disturbances in bowel bacterial flora ("Dysbiosis of Gut Microbiota") brought about by a poor diet creates an increase in gut mucosal permeability, with a resultant increase in the passage of lipopolysaccaride (LPS) from Gram negative colonic bacteria into the systemic circulation.


The resultant activation of the immune system interferes with insulin receptor function, driving up serum insulin levels, which in turn increases the ovaries production of androgens and interferes with normal follicle development.


Thus, the Dysbiosis of Gut Microbiota (DOGMA) theory of PCOS can account for all three components of the syndrome-anovulation/menstrual irregularity, hyper-androgenism (acne, hirsutism) and the development of multiple small ovarian cysts.

 

[Otis Mack]

https://www.ncbi.nlm.nih.gov/pubmed/30800111

Polycystic ovary syndrome (PCOS) is a frequent endocrine and metabolic syndrome in reproductive-age women.

Recently, emerging evidence has shown that gut microbiota is closely related to metabolic diseases such as type 2 diabetes, obesity and PCOS.


In the present study, we established dihydrotestosterone (DHT)-induced PCOS rats and used Illumina MiSeq sequencing (PE300) to examine the composition, diversity, and abundance of the gut microbiota in PCOS.

We compared the effects of three PCOS treatments: Diane-35 (estrogen and progesterone), probiotics and berberine. The DHT-induced rats showed constant estrous cycles, the loss of mature ovarian follicles, insulin resistance and obesity.


The reproductive and metabolic functions in the PCOS rats were improved by treatment with Diane-35 and probiotics.

Diane-35 and probiotics could restore the diversity of the gut microbiota, and the recovery of gut microbiota disorders improved the reproductive function in PCOS-like rats.

However, berberine drastically reduced the species diversity and amount of gut microbiota and showed no improvement in PCOS. The findings of this study will help us to better understand the influence of the gut microbiota in the metabolic and reproductive alterations in PCOS as well as suggest opportunities for future personal dietary guidance for PCOS.

 

[Otis Mack]

https://gut.bmj.com/content/45/2/223


The “gut origin of sepsis” hypothesis proposes that bacteria, which are normally resident within the lumen of the intestinal tract, translocate across the intestinal epithelial barrier and act as a source of sepsis at distant sites.1 2 Many animal studies support this concept.3 4 A number of factors have been shown to predispose to bacterial translocation. These include shock with reduced splanchnic blood flow, parenteral nutrition, intestinal epithelial damage, and antibiotic therapy.4

"Taken with other reports we consider that bacterial translocation probably occurs in all individuals but is not clinically significant in the presence of a fully functional immune system."

Do androgens suppress immune function? Yes they do.

 

[GG66]

Now im confused this study actually states Lactobacillus reuteri helps unless there's a difference between Lactobacillus reuteri and Lactobacillus?????
I get it it's mice but what study isn't today with hair loss
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547054/

 

[Throwaway94]

Now im confused this study actually states Lactobacillus reuteri helps unless there's a difference between Lactobacillus reuteri and Lactobacillus?????
I get it it's mice but what study isn't today with hair loss
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547054/

Lactobacillus is the genus, to which belongs a huge variety of species that can all do very different things. It's very important to be specific down to the species or even strain when it comes to microbes.

 

[Otis Mack]

The thing about taking probiotics is that if you have some defect either physical injury or genetic problem then the probiotics will just increase the amount of LPS in the system.

I started researching the permeability issue and one of the apoLipoproteins and dht. The hypothesis was that if dht in susceptible individuals would somehow screw with apolipoprotein E(making it "null" so to speak in dht susceptible individuals) then we would have a smoking gun
so to speak on how gut bacteria get an overload of LPS in our systems.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485310/


Recent data demonstrate that intestinal microorganisms could influence lipid metabolism and act as environmental factors triggering development of metabolic and cardiovascular diseases (Vrieze et al., 2010; Goldsmith and Sartor, 2014).

The lack of gut microbiota in germ-free apolipoprotein E (ApoE)-null mice, an experimental model of human atherosclerosis, was found to induce the development of atherosclerotic plaques even when animals were fed a standard low-cholesterol diet.

Colonization with normal human microbiota prevented atherogenesis in germ-free ApoE-null mice fed a standard low-cholesterol diet but not a diet with high cholesterol content (Stepankova et al., 2010). Indeed, these observations suggest on the atheroprotective effects of human colonic commensal bacteria.

Increased intestinal microbiota-derived lipopolysaccharide (LPS) load from the colon lumen was shown to be associated with various metabolic abnormalities including induction of adipose inflammation and insulin resistance (Cani et al., 2007).

Bacterial LPS could be delivered from the gut to the circulation through chylomicron-associated transport and via tight junctions in the epithelial lining (Caesar et al., 2010).

LPS is absorbed by enterocytes and transferred to the Golgi apparatus where chylomicrons synthesized by enterocytes are stored before secretion (Sabesin and Frase, 1977). Inhibition of chylomicron formation suppressed intestinal LPS absorption (Ghoshal et al., 2009). High-fat meal intake increases circulating levels of LPS (Amar et al., 2008).

Enhanced LPS load across the tight junctions of the gut epithelium was observed in animal models of human obesity and associated with the rearrangement of tight junction proteins, reduced epithelial barrier function, and increased gut permeability, endotoxemia, and inflammation (Brun et al., 2007; Cani et al., 2008).


Administration of antibiotics or prebiotic oligofructose was shown to improve the integrity of intestinal epithelium and decrease serum low density lipoproteins (LDLs) and liver inflammation (Cani et al., 2009


{ I have read in some other newsgroups(non-hair) about certain types of antibiotics in which the people were reporting hair growth. The thing is when people who arent really looking at hair growth but just recovery from a disease and notice hair growth is a very important find.


Oligofructose? .....HMMM

 

[Otis Mack]

This could relate back to this old post about sepsis because during sepsis you are given a variety of antibiotics.

Could these antibiotics which this guy had somehow reset his intestinal bacteria?


This one I dont know if he means "new" hair growth in Androgenetic Alopecia areas or just refilling in hair lost during sepsis. I will post it anyways:

https://www.hairlosstalk.com/intera...children-work-two-jobs-and-have-a-cat.120839/


https://www.hairlosstalk.com/interact/threads/a-story-about-hairloss-reveresed.36437/

 

[Otis Mack]

Where is the hyperlipedemia(shown in a couple studies) in Androgenetic Alopecia coming from? Our guts obviously as influenced by the types and diversity of gut microbes.

https://www.ncbi.nlm.nih.gov/pubmed/30836215

CONCLUSION:
These results demonstrated that the polyphenol-rich PTF as a unique gut microbiota modulating agent and highlighted the richness of Lactobacillus and the decreased abundance of Bacteroides and Alistipes as an effective indicator of the therapeutic effect of medicinal foods on hyperlipidaemia.


https://www.ncbi.nlm.nih.gov/pubmed/30634484

Oral administration of asperlin for 12 weeks significantly suppressed HFD-induced body weight gain and fat deposition without inhibiting food intake. Hyperlipidemia and liver steatosis were also substantially ameliorated

 

[fugged]

Bacteria do a lot. Definitely more to the picture than just that though of course. I was making yogurt with a few strains of L. reuteri that also showed a major increase in mouse hair density and health.. Im saying that fully understanding that mice and humans don't always mean apples to apples as we know. However L. reuteri is a bacteria that we have (or had more of once), and this was all studied my MIT. The yogurt may have helped but became a pain to make every week... I wonder about just amplifying it with water and a prebiotic instead of pastyeurizing half and half every week. Also the way we distinguish amongst bacteria is a bit different than we do with higher organisms, and apparently even amongst the same genus and species, the *strains* are very distinct and can do different things to their hosts. Its not at all unreasonable to inquire about a bacterial element, we have something like 7 times the number of bacterial cells living in us than our own human cells. We are composite, microbial beings.

 

[Armando Jose]

https://gut.bmj.com/content/45/2/223


The “gut origin of sepsis” hypothesis proposes that bacteria, which are normally resident within the lumen of the intestinal tract, translocate across the intestinal epithelial barrier and act as a source of sepsis at distant sites.1 2 Many animal studies support this concept.3 4 A number of factors have been shown to predispose to bacterial translocation. These include shock with reduced splanchnic blood flow, parenteral nutrition, intestinal epithelial damage, and antibiotic therapy.4

"Taken with other reports we consider that bacterial translocation probably occurs in all individuals but is not clinically significant in the presence of a fully functional immune system."

Do androgens suppress immune function? Yes they do.

Your post are very valuable but in our case we need a type of Kompass, due the special pattern of common hair loss, we need ask ever why a X factor can afect only certains hair. In this case, gut bacterias.

 

[Armando Jose]

Do androgens suppress immune function? Yes they do

Also stress.