Gynecomastia And Finasteride Considerations.

frank1980

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I wanted to share some information with users from what I have learned and what I believe happens. Many people, including myself, are scared for side effects while taking finasteride/propecia. After spending countless hours reading, searching, and debating weather to taked it, I finally decided to get on it. I'm taking .25mg daily which is a fourth of the normal dosage, but from various studies is over half as effective as taking the full amount. The downside is that if it still kills over half the dht that a full dose does, that also means that the sides will be about half as bad as well. Many of the potential side effects of finasteride are quite confusing. However, I believe I have a decent grasp on possible gynecomastia.

Most studies I have seen report a 1% chance of developing gyno. This isn't that far off from the placebo group.

I believe finasteride induced gynecomastia is unlikely. As we know, finasteride blocks the enzyme that converts testosterone to dht. It also doesn't completely eliminate dht like dutasteride does which I believe is around 98%. Since less testosterone is being converted to dht, there is more free floating testosterone, so your other testosterone related functions will be increased. This also means that your estrogen will increase. How much? Well it generally seems to be in the 10 to 15% range. This in the vast majority of times will not be enough to induce gynecomastia. The average healthy male has estradiol levles between 10 to 40. Some even list as 20 to 55. Significantly overweight men seem to have higher levels. Often as high as 80 and the vast majority of them also do not get true gynecomastia (i'm not talking about excess chest fat which creates a fake appearance of gynecomastia).

If finasteride causes gynecomastia, it probably means that you were at a high level of estradiol already and/or had minor gynecomastia already. This extra bump will may have triggered it.

The easiest way to take a wild guess as to how likely you are to have this happen is to do a blood test prior to finasteride. I wish I did. If you see that you have high estradiol levels to begin with, it will give you something to mull over on whether or not to start finasteride. If you do have healthy or low levels of estradiol, it is even less likely you will develop gynecomastia or other excess estrogen induced conditions. If you do take a blood test and decide to take finasteride, I would also think about getting blood work done after a month or two to see where your levels are at. One final thing to think about, work out and eat well. Getting your weight down seems to reduce the chances.

Sorry to over simplify this, but I figured it might help some people.
 

Manochoice

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Please do keep us posted with how your experience is on the treatment. I did notice quite a few reports from Fina users regarding Gynecomastia so I thinks there's a real concern there. Good luck on your journey!
 

frank1980

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Please do keep us posted with how your experience is on the treatment. I did notice quite a few reports from Fina users regarding Gynecomastia so I thinks there's a real concern there. Good luck on your journey!
Thanks, I appreciate it. However, I think my fina journey will be ending soon. I will be starting an ru experiment though.
 

Manochoice

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Thanks, I appreciate it. However, I think my fina journey will be ending soon. I will be starting an ru experiment though.

Why are you already ending it? I've heard/read some nasty stories about RU also. Of course opinions are divided. But RU is does not really have risks assessed too well as far as I understand.
 

frank1980

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Why are you already ending it? I've heard/read some nasty stories about RU also. Of course opinions are divided. But RU is does not really have risks assessed too well as far as I understand.
I understand, but ru has no effect on systemic testosterone and hormone levels
 

abcdefg

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I understand, but ru has no effect on systemic testosterone and hormone levels

Yes it does. Shutting down receptors raises your testosterone because its no longer doing what it did before so its floating around when it was not before. I mean it pretty much must go systemic to some point, and you have to worry what other organs or places have receptors its going to interfere with? With no large phase 3 studies its pretty open for debate how safe RU really is.
 

frank1980

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That's a good point. However, how much dht can these receptors possibly take up? Im sure it cant be that much. If I lose enough follicles, I'll have enough less dht receptors anyways. Lol. As far as ru going systemic, I dont think much of it can from what I have read. http://www.ru58841.info/side-effects/
 
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abcdefg

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That's a good point. However, how much dht can these receptors possibly take up? Im sure it cant be that much. If I lose enough follicles, I'll have enough less dht receptors anyways. Lol. As far as ru going systemic, I dont think much of it can from what I have read. http://www.ru58841.info/side-effects/

Yeah it raises T, but its probably less than something like finasteride. Most topicals do go systemic its just a question of how much, and if they do anything or are even absorbed enough.
Gyno on finasteride was near placebo, but we have to keep in mind a study of 1000 men might be far off from real world use in millions of men. Could be quite a bit higher or lower in real world use. Its tough to guess so just need to rely on the studies, but from the studies gyno is a very very very rare occurrence. Some men get gyno simply from aging and natural hormone changes. Hormones dont stay the same forever.
 

Manochoice

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Yeah it raises T, but its probably less than something like finasteride. Most topicals do go systemic its just a question of how much, and if they do anything or are even absorbed enough.
Gyno on finasteride was near placebo, but we have to keep in mind a study of 1000 men might be far off from real world use in millions of men. Could be quite a bit higher or lower in real world use. Its tough to guess so just need to rely on the studies, but from the studies gyno is a very very very rare occurrence. Some men get gyno simply from aging and natural hormone changes. Hormones dont stay the same forever.

I agree with what you said about the study of 1000 men. It can't possibly identify all problems that might arise when applied to millions of consumers. That is why when finasteride was prescribed to millions of users it all of a sudden started highlighting thousands of very severe cases, probably PFS. Indeed, thousands out of millions would only yield percentages of under 1% (say 0.X%) that the initial studies couldn't have statistically and realistically identify. But still, if you want to rely on studies you must accept the reality that there is a 0.X% chance it will destroy your life. One must have that in mind and be informed before starting this road.
 

abcdefg

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I agree with what you said about the study of 1000 men. It can't possibly identify all problems that might arise when applied to millions of consumers. That is why when finasteride was prescribed to millions of users it all of a sudden started highlighting thousands of very severe cases, probably PFS. Indeed, thousands out of millions would only yield percentages of under 1% (say 0.X%) that the initial studies couldn't have statistically and realistically identify. But still, if you want to rely on studies you must accept the reality that there is a 0.X% chance it will destroy your life. One must have that in mind and be informed before starting this road.

Agreed. We really should have a topical drug for male pattern baldness by now. Topically it just makes sense your going to get less systemic absorption generally speaking. That is the goal I mean its a topical problem why are we still taking internal drugs for this problem 30 years later?
 
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