- Reaction score
- 2,721
Light microscopic picture of hair follicles treated with Carthamus tinctorius extract (CTE) and minoxidil showing intact morphology at 72 h incubation. *Significant difference from untreated group at p < 0.05 (n = the number of hair follicle).
The florets of Carthamus tinctorius L. have traditionally been used for hair growth promotion. This study aimed to examine the potential of hydroxysafflor yellow A‐rich C. tinctorius extract (CTE) on hair growth both in vitro and in vivo. The effect of CTE on cell proliferation and hair growth‐associated gene expression in dermal papilla cells and keratinocytes (HaCaT) was determined. In addition, hair follicles from mouse neonates were isolated and cultured in media supplemented with CTE. Moreover, CTE was applied topically on the hair‐shaved skin of female C57BL/6 mice, and the histological profile of the skin was investigated. C. tinctorius floret ethanolic extract promoted the proliferation of both dermal papilla cells and HaCaT and significantly stimulated hair growth‐promoting genes, including vascular endothelial growth factor and keratinocyte growth factor. In contrast, CTE suppressed the expression of transforming growth factor‐β1 that is the hair loss‐related gene. Furthermore, CTE treatment resulted in a significant increase in the length of cultured hair follicles and stimulated the growth of hair with local effects in mice. The results provided the preclinical data to support the potential use of CTE as a hair growth‐promoting agent. Copyright © 2013 John Wiley & Sons, Ltd. https://onlinelibrary.wiley.com/doi/full/10.1002/ptr.5100
HAIR GROWTH PROMOTING ACTIVITY OF CARTHAMUS TINCTORIUS FLORETS EXTRACT-LOADED NANOSTRUCTURED LIPID CARRIERS
Methods: Safflower florets were extracted by maceration with ethanol, and then incorporated into NLC formula. Safflower extract-loaded NLCs were assessed for their physical properties, stabilities and hair growth promoting activity in C57BL/6 mice.
Results: Safflower-loaded NLCs had particle size around 100 nm, zeta potential in the range of -40 to -49 mV. The data from DSC and XRD suggested that this NLC occurred as an amorphous type NLC. Safflower extract-loaded NLC promoted hair growth in the mice better than minoxidil. Safflower yellow, the principle phytochemical in safflower extract, along with synergistic activity between other phytochemicals may account for hair growth promoting activity observed in mice. The further investigations in human volunteer should be conducted for the confirmation.
https://innovareacademics.in/journals/index.php/ijpps/article/view/3927
5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment
Aims of the study
The purpose of this research is to define the possible mechanisms involved in hair loss treatment of the selected plants by determining the 5α-reductase enzyme inhibition and hair growth promoting activities, and the relationship between these two activities.
Materials and methods
Seventeen Thai plants traditionally used for hair treatment were selected. The plants were dried, ground and extracted by maceration with ethyl alcohol. These extracts were further tested for 5α-reductase inhibition using enzymes from rat livers. Hair growth promoting activity was tested in C57BL/6 mice.
Results
Carthamus tinctorius L. was the most potent 5α-reductase inhibitor, with a finasteride equivalent 5α-reductase inhibitory activity (FEA) value of 24.30 ± 1.64 mg finasteride equivalent per 1 g crude extract. Phyllanthus emblica L. was the second most potent inhibitor, with FEA of 18.99 ± 0.40. Rhinacanthus nasutus (L.) Kurz. was the least potent 5α-reductase inhibitor (FEA 10.69 ± 0.96). Carthamus tinctorius also was the most potent hair growth promoter in C57BL/6 mice. There were strong relationships between 5α-reductase inhibitory activity and hair growth promoting activity (r = 0.719), and between 5α-reductase inhibitory activity and hair follicle count (r = 0.766).
https://www.sciencedirect.com/science/article/pii/S0378874111008774
HAIR GROWTH PROMOTING ACTIVITY OF CARTHAMUS TINCTORIUS FLORETS EXTRACT-LOADED NANOSTRUCTURED LIPID CARRIERS
Methods: Safflower florets were extracted by maceration with ethanol, and then incorporated into NLC formula. Safflower extract-loaded NLCs were assessed for their physical properties, stabilities and hair growth promoting activity in C57BL/6 mice.
Results: Safflower-loaded NLCs had particle size around 100 nm, zeta potential in the range of -40 to -49 mV. The data from DSC and XRD suggested that this NLC occurred as an amorphous type NLC. Safflower extract-loaded NLC promoted hair growth in the mice better than minoxidil. Safflower yellow, the principle phytochemical in safflower extract, along with synergistic activity between other phytochemicals may account for hair growth promoting activity observed in mice. The further investigations in human volunteer should be conducted for the confirmation.
https://innovareacademics.in/journals/index.php/ijpps/article/view/3927
5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment
Aims of the study
The purpose of this research is to define the possible mechanisms involved in hair loss treatment of the selected plants by determining the 5α-reductase enzyme inhibition and hair growth promoting activities, and the relationship between these two activities.
Materials and methods
Seventeen Thai plants traditionally used for hair treatment were selected. The plants were dried, ground and extracted by maceration with ethyl alcohol. These extracts were further tested for 5α-reductase inhibition using enzymes from rat livers. Hair growth promoting activity was tested in C57BL/6 mice.
Results
Carthamus tinctorius L. was the most potent 5α-reductase inhibitor, with a finasteride equivalent 5α-reductase inhibitory activity (FEA) value of 24.30 ± 1.64 mg finasteride equivalent per 1 g crude extract. Phyllanthus emblica L. was the second most potent inhibitor, with FEA of 18.99 ± 0.40. Rhinacanthus nasutus (L.) Kurz. was the least potent 5α-reductase inhibitor (FEA 10.69 ± 0.96). Carthamus tinctorius also was the most potent hair growth promoter in C57BL/6 mice. There were strong relationships between 5α-reductase inhibitory activity and hair growth promoting activity (r = 0.719), and between 5α-reductase inhibitory activity and hair follicle count (r = 0.766).
https://www.sciencedirect.com/science/article/pii/S0378874111008774
