Has Anyone Had Success From Pge2 Alone

[Gone]

Or an antiandrogen/setipripant with PGE2 as the sole stimulant?

 

[Beowulf]

I think a guy on Tressless did earlier this year, he hasn't reported back yet.

I'm pretty sure that's in the Brotzu lotion as well. He claims that it can increase the proliferation of epithelial cells, but instead of making a claim about hair follicle stem cells he said this was to increase micro circulation which is understandable since he doesn't really know anything about hair follicle biology.

There are old threads about it on other forums which sort of flip flopped. It's so weird seeing unfamiliar faces discussing hair loss, I wonder where they all went?

https://www.hairlosstalk.com/intera...n-enigma-experimental-topical-solution.90329/

 

[Folliman]

You have to stop PGD2 for PGE2 to have any effect

 

[plisk]

as far as i remember there were concerns that the chinese were supplying fake or incomplete synthesis, and then there was the follow on concern, that once a legit source of PGE2 was procured, it was very expensive.

Even if something came out that has undeniable efficacy, to be quite honest, i wouldnt trust most hair loss community members to actually pursue it if it involves difficulty, cost or discomfort. Remember the minoxidil + dermarolling "community" trial? So, so many people who tried it halfheartedly on and off. Little wonder then that one of the only people who had good results (stellar actually when you see his before picture) was religious about it for over a year.

 

[Swoop]

Viprostol which is a PGE2 analogue ultimately wasn't considered to be an effective hair growth promoter, although it showed some hair growth counts initially apparently in some people.

Viprostol is a synthetic prostaglandin E analogue would seem to be to be an effective vasodilater and antihypertensive drug (unpublished data).* Its mode of action as an antihypertensive appears to be the reduction of peripheral resistance through its relaxing actions on smooth muscle. Early studies suggested that direct application of viprostol to the bald scalp promotes hair growth and the transformation of vellus to terminal hair by increasing nutritive blood flow to the scalp.

Equivocal evidence of mild liver dysfunction was noted in a preliminary study in healthy subjects after they received repeated doses of 120 pg of viprostol to the bald scalp. A rechallenge study, however, showed no effect on serum transaminase levels, indicating no clinically significant trend or safety concerns with regard to liver dysfunction.* No other side effects were reported.

A l-year, double-blind, placebo-controlled study was conducted to determine the effectiveness of viprostol in patients with male-pattern baldness. The study was conducted at 10 centers including Northwestern University Medical School. Each center enrolled 20 patients. Seventeen of our patients completed 6 months and 13 completed the l-year treatment period. At the end of the l-year study, ten patients had increased hair growth from baseline and five of these patients doubled their terminal hair count; three patients had no noticeable hair growth (Table 17-1). All of our viprostol-treated patients had increased hair growth at 24 weeks, and six of the 10 doubled their hair count by 50 weeks. Three of the seven placebo-treated patients had increased hair growth. Curiously, when data were collected from all of the centers, hair-growing activity could not be substantiated and the studies were discontinued."

Olsen also did a study with the PGE2 analogue Viprostol; https://www.ncbi.nlm.nih.gov/pubmed/2212146

Fifty-seven men were randomly assigned for treatment of androgenetic alopecia with viprostol, vehicle, or placebo twice daily for 24 weeks. Nonvellus hair growth was assessed subjectively by both patient and investigator and objectively through hair counts from macrophotographs of the target area. Nonvellus target area hair counts declined in all three treatment groups at the end of the 6-month study. Viprostol is not an effective hair growth promoter in androgenetic alopecia.

Perhaps the initial study was just not performed well.

Also the Viprostol probably doesn't have the same biological activity as PGE2. So take that into account.

That being said PGE2 probably gets heavily outperformed by minoxidil. There are no reasons to argue that PGE2 would be a strong hair growth promoter.

PGF2a is a hair growth promoter and actually has evidence backing it up (latanoprost study and bimatoprost clinical trials).

There is very little doubt that prostaglandins have a role in the hair follicle cycle. However to argue that they have a primary role in Androgenetic Alopecia is a far stretch. We'll need to have proof of that, until then it's a (weak) hypothesis.

 

[Gone]

^Swiss Temples' prostaglandin chart claims that PGE2 is converted to PGF2a in the body, so PGE2 could be theoretically more useful.

Plisk I think you're right that forum experiments can often go astray, I wonder if there's a user who documented it will with just a maintenance drug and PGE2, that would be really helpful (Folliman I mentioned that in the OP that a maintenance drug with PGE2 might be needed to show its efficacy)

Beowulf I'd be very interested to hear how the guy on Tressless does, it sounds like the kind of experiment I'm looking for. We can't let him drop off without sharing his results lol

 

[Rick Grimes]

Does anyone have a source for PGE2? If so could you PM me or post here? Any help would be greatly appreciated... right now I'm doing minoxidil + seti + microneedling and want to see if adding PGE2 will help... so far I'm thickening what I've got but I am trying to go for a little regrowth in front of the hairline

 

[Sanchez1234]

Guys, its now 2 years later and more people use pge2. Would pge2 on its own bring any succes without seti?
@westonci

 

[ALightInTheDark]

Guys, its now 2 years later and more people use pge2. Would pge2 on its own bring any succes without seti?
@westonci

Read once again Cotsa researches, it will answer your question