How Real Is The Nocebo Effect When It Comes To Finasterid?

[randolf_faust]

any studies on nocebo effect regarding finasterid?

 

[Redgate]

https://www.ncbi.nlm.nih.gov/pubmed/17655657
"In the current study, blinded administration of finasteride was associated with a significantly higher proportion of sexual dysfunction in patients informed on sexual side effects (group 2) as compared to those in which the same information was omitted (group 1)"
https://www.ncbi.nlm.nih.gov/pubmed/14585251 (not finasteride -- atenolol, can also cause ED)
"During the first phase of the study patients received atenolol 50mg o.d. (A), 32 patients were blinded on the drug given (group A), 32 were informed on the drug given but not on its side effects (group B) and 32 took A after being informed on its side effects on erectile function (group C). After 3 months the incidence of erectile dysfunction was 3.1% in the group A, 15.6% in group B and 31.2% in group C (P<0.01)."

This article references the above two studies and has some more information on the nocebo effect: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655643/

 

[randolf_faust]

https://www.ncbi.nlm.nih.gov/pubmed/17655657
"In the current study, blinded administration of finasteride was associated with a significantly higher proportion of sexual dysfunction in patients informed on sexual side effects (group 2) as compared to those in which the same information was omitted (group 1)"
https://www.ncbi.nlm.nih.gov/pubmed/14585251 (not finasteride -- atenolol, can also cause ED)
"During the first phase of the study patients received atenolol 50mg o.d. (A), 32 patients were blinded on the drug given (group A), 32 were informed on the drug given but not on its side effects (group B) and 32 took A after being informed on its side effects on erectile function (group C). After 3 months the incidence of erectile dysfunction was 3.1% in the group A, 15.6% in group B and 31.2% in group C (P<0.01)."

This article references the above two studies and has some more information on the nocebo effect: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655643/

thanks man !