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- 498
If spironolactone has to be converted by the liver to work, why does topical spironolactone work for acne?
- Thread starter sonictemples
- Start date
spironolactone has several active metabolites, some are activated in the liver, and some are not. Oral spironolactone acts on multiple pathways, but I IIRC topical only acts on the AR. It should work, but not as well as oral.
- Reaction score
- 1,027
In Spain, they made lotion with Canrenone ( canrenona if you want to search for it ) , that is the active metabolite of spironolactone.