igf-1 and hair growth

[cthulhu]

There was a recent study in December 2012 where they applied igf-1 in liposomes to bald mice and the mice grew thicker and more hair. Also, in 2006 there was a human study where participants took a combination of capsaicin and soy and 88% of subjects regre hair due to higher skin levels of igf-1. I was reading how Dihydrotestoserone lowers igf-1 and thus would suggest igf-1 should be the main focus. Anyone have any thoughts on this?

 

[Sparky4444]

88% of human subjects regrew hair?? If that is legit, how did that slip through the cracks??

 

[cthulhu]

that's exactly what I was thinking, you can find the exact study on pubmed. They performed the test not only on mice but on humans and got the same result. just type in soy capsaicin into the search.

 

[Sparky4444]

So cayenne pepper into the topical then?? That stuff is potent -- I used it as a last ditch emergency throat remedy when i was a musician on the road and lost my voice all the time...save my *** but it is brutal...

Thinking to add the cayenne to the CET/Tricomin/Rosmarinus brew I've been spraying on my vertex area every night....

 

[ohmanohno]

Interesting..

 

[cthulhu]

Hey Sparx, check out this study:
[h=1]Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans.[/h]Harada N, Okajima K, Narimatsu N, Kurihara H, Nakagata N.
[h=3]Source[/h]Department of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.

[h=3]Abstract[/h]Sensory neurons release calcitonin gene-related peptide (CGRP) on activation. We recently reported that topical application of capsaicin increases facial skin elasticity and promotes hair growth by increasing dermal insulin-like growth factor-I (IGF-I) production through activation of sensory neurons in mice and humans. Raspberry ketone (RK), a major aromatic compound contained in red raspberries (Rubus idaeus), has a structure similar to that of capsaicin. Thus, it is possible that RK activates sensory neurons, thereby increasing skin elasticity and promoting hair growth by increasing dermal IGF-I production. In the present study, we examined this possibility in mice and humans. RK, at concentrations higher than 1 microM, significantly increased CGRP release from dorsal root ganglion neurons (DRG) isolated from wild-type (WT) mice and this increase was completely reversed by capsazepine, an inhibitor of vanilloid receptor-1 activation. Topical application of 0.01% RK increased dermal IGF-I levels at 30 min after application in WT mice, but not in CGRP-knockout mice. Topical application of 0.01% RK increased immunohistochemical expression of IGF-I at dermal papillae in hair follicles and promoted hair re-growth in WT mice at 4 weeks after the application. When applied topically to the scalp and facial skin, 0.01% RK promoted hair growth in 50.0% of humans with alopecia (n=10) at 5 months after application and increased cheek skin elasticity at 2 weeks after application in 5 females (p<0.04). These observations strongly suggest that RK might increase dermal IGF-I production through sensory neuron activation, thereby promoting hair growth and increasing skin elasticity.

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50% growth rate for humans is pretty good stuff. More evidence that igf-1 is key for hair growth

 

[Sparky4444]

yeah..you hit it on the head -- when the same topic pops up from different sources, you gotta perk your ears up...soy is one of those...and I put CET in that as well, given I have seen it actually do something for me at least on the maintaining side of things, and with some stubs popping up here and there...

...given that, I am putting CET at the base of the topical and looking to add boosters to it...tricomin and rosmarinus being easy to add to that...and seeing how i react to putting cayenne in there will be interesting...this way, I don't give up on the routine because at the heart of it, I know CET is doing something...adding the other stuff is along for the ride...

 

[Chromeo]

That sounds good to me, Sparx. CET certainly has an effect, it's just about tweaking the regime and maximizing the potential for greater regrowth. If one or two things can be added to speed things up, all the better.

 

[cthulhu]

wasn't cetirizine shown to be effective for alopecia areata?

 

[Sparky4444]

wasn't cetirizine shown to be effective for alopecia areata?

lol...the longest thread in history on this topic under this sub-forum I believe ;-)

the coles notes on CET from my point of view is that it is very, very good at maintaining...it will sprout up some hairs, better for some then others in terms of regrowth...

IMHO, better alternative than minoxidil...no alcohol in the solution...I use water and some tricomin...I would think that higher conc's of SOD would prolly be even better...

Gonna try some test solutions to see if cayenne pepper will actually dissolve in water....from what I remember for my throat remedy, it didn't play to nice with lemon juice ....

 

[ohmanohno]

Do you guys think its possible and likely that alcohol in minoxidil products causes hairloss??

 

[cthulhu]

No, in the clinical studies involving minoxidil they used a placebo using water and a placebo involving alcohol and they had the same result. Thus, applying alcohol topically does not cause hairloss

 

[Sparky4444]

Do you guys think its possible and likely that alcohol in minoxidil products causes hairloss??

it drives my effin' crazy though with the itch...some people's skin can't take it...

 

[cthulhu]

just use it once a day, I think you're less likely to develop a tolerance than if you apply twice a day.

 

[Sparky4444]

just use it once a day, I think you're less likely to develop a tolerance than if you apply twice a day.

nope...not going to happen..

anyways...how do we get cayenne/chili, etc pepper, into a solution?? Pretty sure it won't dissolve in water...or very little anyways...

 

[cthulhu]

The purpose of the rasberry ketone study was to find an alternative to cayenne, considering cayenne burns like hell when put on the scalp. Since rasberry ketone doesn't burn and has the same structure, it makes a much better alternative. Only problem is they don't really specify the formulation, just mention that it is a .01% rasberry ketone mixture

 

[boobyinspector]

Take DHEA then as it increases igf-1.

 

[Sparky4444]

Take DHEA then as it increases igf-1.

Well, that's a good reminder booby...if only from a health perspective, fish oil should be in the diet mix regularly...I think I am going to turf a few of the vit's and crap that doesn't really do much and get back on fish oil..

 

[AdrenergicAddict]

IGF-1 is available all over the internet and is not currently regulated as a drug. I'd assume liposomal delivery systems are too complex to make without a legitimate lab, but it would be interesting to see the results of extended application. Maybe even better: dermaroller + liposomal IGF-1.

 

[cthulhu]

yeah, i'm guessing alcohol as a vehicle doesn't work or they probably would have tried it