Gadgetine

In vitro production of hair shafts by Javanese researchers

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ppma

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Nice breakthrough. Link to the paper. https://www.science.org/doi/10.1126/sciadv.add4603

Rodents always have the solution for their hair loss before humans, but these researchers are now for sure up to creating some spin-off or looking for funding for humans exploitation of the culture protocol. I do not think even in Japan in vitru culturing is much of an ethics concern so as to delay further studies with human cells. We should be getting news from them soon, hopefully.
 
kiwi666

kiwi666

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This is cool. It’s neat to see a grown follicle like that using a different methodology we haven’t discussed and didn’t know about.

Another small step for balding kind :)

Here’s another link reporting on it.

Scientific breakthrough could help develop new hair loss treatments

Japanese scientists believe their work could open up new research avenues for the development of fresh treatment strategies for hair loss disorders, including alopecia, which affects both women and men.
news.sky.com
 
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ppma

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As demonica kiwi's article poits out, we, baldies are only concerned for the immadiate application of HF harvesting for later transplantation. But furthermor this sort of cultured brand new HFs can be an ideal study scenario for Androgenetic Alopecia itself into testing potential treatments and even gene editing, as in my guess both DHT resistant and DHT sensitive follicles could be harvested and studied in identical environments.

Its worth is both as a potential pathway towards unlimited donor HFs, and also as a step forward in hairloss research in general.
 
Raccooner

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I have an idea for these Japanese (or Javanese scientists the poster suggests [gamelan anybody?]): stop using mice to grow hair! Why must they ALWAYS use mice? Do scientists worship a mouse god or something and therefore must always use them as the chosen ones? I mean seriously, you could fart, tickle, defecate or vomit on a mouse, and it will probably find a way to grow new hair follicles. Don't they have anything else they can use other than a mouse? Lots of mammals out there to choose from. How about a raccoon???? Yeah, I know some of those critters are roaming around that volcanic batch of islands. Joking aside, a mean really, do they expect anyone to take their work seriously if they keep using mice to say we made new hairs grow? Anyone who knows anything about this and isn't full of doodoo knows that mice grow hair easily. No one is going to get excited that hair was made to grow on a mouse even if with nearly 100% consistency. It's not news until they've gotten it to work on an animal, say like a PIG! Hey Stemson, got any pork rinds or hairy pigs by chance?

1666486841165.png
 
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MeDK

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Raccooner said:
I have an idea for these Japanese (or Javanese scientists the poster suggests [gamelan anybody?]): stop using mice to grow hair! Why must they ALWAYS use mice? Do scientists worship a mouse god or something and therefore must always use them as the chosen ones? I mean seriously, you could fart, tickle, defecate or vomit on a mouse, and it will probably find a way to grow new hair follicles. Don't they have anything else they can use other than a mouse? Lots of mammals out there to choose from. How about a raccoon???? Yeah, I know some of those critters are roaming around that volcanic batch of islands. Joking aside, a mean really, do they expect anyone to take their work seriously if they keep using mice to say we made new hairs grow? Anyone who knows anything about this and isn't full of doodoo knows that mice grow hair easily. No one is going to get excited that hair was made to grow on a mouse even if with nearly 100% consistency. It's not news until they've gotten it to work on an animal, say like a PIG! Hey Stemson, got any pork rinds or hairy pigs by chance?

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They do it to set themself up to success.

And to keep themself attractive to investors for their science projects they have to show they are successful, whether or not it can be commercialized is different thing.
 
C

coolio

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Mice are very cheap.

Trails on stumptailed macaques (which would actually tell us something) are very expensive.
 
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Joxy

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Junji is hard working scientists, but these kind of treatments will take years and years till they get to point to start clinical trials. This is the future, but for now we are far away from that future.
 
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Joxy

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Raccooner said:
I have an idea for these Japanese (or Javanese scientists the poster suggests [gamelan anybody?]): stop using mice to grow hair! Why must they ALWAYS use mice? Do scientists worship a mouse god or something and therefore must always use them as the chosen ones? I mean seriously, you could fart, tickle, defecate or vomit on a mouse, and it will probably find a way to grow new hair follicles. Don't they have anything else they can use other than a mouse? Lots of mammals out there to choose from. How about a raccoon???? Yeah, I know some of those critters are roaming around that volcanic batch of islands. Joking aside, a mean really, do they expect anyone to take their work seriously if they keep using mice to say we made new hairs grow? Anyone who knows anything about this and isn't full of doodoo knows that mice grow hair easily. No one is going to get excited that hair was made to grow on a mouse even if with nearly 100% consistency. It's not news until they've gotten it to work on an animal, say like a PIG! Hey Stemson, got any pork rinds or hairy pigs by chance?

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Many drugs were tested on mice in the past and they are doing quite well on humans. Mice are good clinical models.

The bad side of Junji method is that it was done with mice stem cells. Not human stem cells. If it was done with human stem cells, then it will be ground breaking.

So far, we are still far away. Maybe decade.
 
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Joxy

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Remember Ernesto Lujan and his dNovo company? It was big hype 6 months ago and this guy went silent.

Actually, my opinion is that this disease is very hard to cure. Just like cancer. Very complicated.

Only possible company that is somehow on the road still is Stemson and Epibiotech.
 
kiwi666

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Joxy said:
Remember Ernesto Lujan and his dNovo company? It was big hype 6 months ago and this guy went silent.

Actually, my opinion is that this disease is very hard to cure. Just like cancer. Very complicated.

Only possible company that is somehow on the road still is Stemson and Epibiotech.
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I’d argue that you don’t really have a clue.

It could be next week, it could be 12 months, it could be 10 years.


Meanwhile bros are getting Hair Transplants at Eugenix and probably don’t care what we think or don’t think / speculate about cutting edge future timelines ‍♂️

https://www.hairestorationetwork.com/topic/63124-eugenix-march-2022-5300-grafts-1300-bht/
 
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Joxy

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kiwi666 said:
I’d argue that you don’t really have a clue.

It could be next week, it could be 12 months, it could be 10 years.


Meanwhile bros are getting Hair Transplants at Eugenix and probably don’t care what we think or don’t think / speculate about cutting edge future timelines ‍♂️

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It won’t be next week. Neither next month, neither next year. Don’t be naive. It will take years and years. Maybe decade or two.

Creating new functional hair follicle is like creating whole new organ. Very complicated, very expensive and many limitations.

All these scientific papers doesn’t mean nothing. Only lab research for education purpose. Creating product and bringing on the market is totally different thing than doing university research. Do you know how many papers there were in the past with similar topics? How many of them became real product? Zero.

And, why they don’t test it their papers on themselves? Oh, mice is different than human head and they are scare of one thing call cancer. Why? Because it is very hard to control stem cells in body.

I like to be very optimistic, but currently I am just realistic.
 
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Raccooner

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Joxy said:
Remember Ernesto Lujan and his dNovo company? It was big hype 6 months ago and this guy went silent.

Actually, my opinion is that this disease is very hard to cure. Just like cancer. Very complicated.

Only possible company that is somehow on the road still is Stemson and Epibiotech.
Click to expand...
Stemson, pfft! Stemson is on the road to bankruptcy. They don't even hire people with the background needed to make a meaningful dent into this. Geoff Hamilton is hurting the company with his bad decision making and going silent. I'd like to know how they spent the $15 million they've been given. My hunch is the money is being thrown out on salaries for people who haven't a clue in how to deal with this matter. Yes, I remember Ernesto Lujan. Yeah, his "successful" experiment is pretty much worthless since I've read more about what is involved. Why do you think Epibiotech is making a difference? I haven't looked into them nearly as much.
 
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J

Joxy

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Raccooner said:
Stemson, pfft! Stemson is on the road to bankruptcy. They don't even hire people with the background needed to make a meaningful dent into this. Geoff Hamilton is hurting the company with his bad decision making and going silent. I'd like to know how they spent the $15 million they've been given. My hunch is the money is being thrown out on salaries for people who haven't a clue in how to deal with this matter. Yes, I remember Ernesto Lujan. Yeah, his "successful" experiment is pretty much worthless since I've read more about what is involved. Why do you think Epibiotech is making a difference? I haven't looked into them nearly as much.
Click to expand...
In what is envolved Ernesto Lujan?
 
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