increasing propecia's effectiveness

[pinkfloyd7]

this may be a stupid question but i was just wonder if there
is any way to make propecia more effetive such as taken any supplements to make it easier for your scalp and body to respond to the medication maybe making it more fully effective? or maybe taking a scalp shampoo like revivogen to aid propecia in cleaning your hair of dht and making it more healthy?


thanks

 

[Chemical J]

100% Absorption Occurs on an empty stomach in the morning.

 

[JohnnySeville]

this may be a stupid question but i was just wonder if there
is any way to make propecia more effetive such as taken any supplements to make it easier for your scalp and body to respond to the medication maybe making it more fully effective? or maybe taking a scalp shampoo like revivogen to aid propecia in cleaning your hair of dht and making it more healthy?


thanks

Try taking it with grapefruit juice, I read somewhere that it may potentiate the effect of finasteride. Grapefruit juice seems to have an effect on various prescription drugs, one way or another.

 

[pologuy514]

I eat grapefruit on a regular basis and i always feel good after eating it. That would rock if it helps w/ my results.

 

[pinkfloyd7]

thanks guys any other suggestions?

 

[sore loser]

The grapefruit juice phenomenon is real - it does in fact increase the bioavailibility of some medications in the body, but as of yet, as far as I am aware, the exact mechanism of how this works is unknown. There is a specific compound in grapefruit juice (bioflavanoid, perhaps naringen some suspect) that inhibits the cytochrome P450 3A4 enzyme, and thus significantly effects the metabolism of any drug that is normally metabolized in a pathway that contains this enzyme.

At the moment I am unsure if Finastaride falls into this category. Any other science-guys know the pathway of finastaride metabolism?

 

[Bryan]

The grapefruit juice phenomenon is real - it does in fact increase the bioavailibility of some medications in the body, but as of yet, as far as I am aware, the exact mechanism of how this works is unknown.

It's not unknown at all. The cytochrome P450 family of enzymes degrades many substances coming into the body generally by an oxidative mechanism.

There is a specific compound in grapefruit juice (bioflavanoid, perhaps naringen some suspect) that inhibits the cytochrome P450 3A4 enzyme, and thus significantly effects the metabolism of any drug that is normally metabolized in a pathway that contains this enzyme.

Exactly.

At the moment I am unsure if Finastaride falls into this category. Any other science-guys know the pathway of finastaride metabolism?

Finasteride and dutasteride are indeed degraded by CYP3A4.

 

[Bryan]

Try taking it with grapefruit juice, I read somewhere that it may potentiate the effect of finasteride. Grapefruit juice seems to have an effect on various prescription drugs, one way or another.

That should work as far as having a "sparing" effect on finasteride goes, but I find it doubtful that the sparing effect would be worth the cost of the grapefruit juice. Probably more cost-effective just to take a larger dose of finasteride.

Dutasteride, on the other hand, is a different story. Since it's more expensive than finasteride, it _may_ be more cost-effective to take it with grapefruit juice, but I don't think anybody knows for sure.

 

[sore loser]

It's not unknown at all. The cytochrome P450 family of enzymes degrades many substances coming into the body generally by an oxidative mechanism.

Thanks Bryan. I was saying the mechanism was "unknown" because I thought the jury was still out on exactly which compound in grapefruit juice inhibited CytP450 3A4. If it has been specifically reported in the literature, I must have missed it.