Inhibition of FGF13 induces hair growth - Dr. Christiano Patent

[hellouser]

SUMMARY OF THE INVENTION

An aspect of the invention encompasses a method of treating a hair-loss disorder in a mammalian subject in need thereof, the method comprising administering to the subject an inhibitor of FGF1. In one embodiment, the hair-loss disorder comprises androgenetic alopecia, telogen effluvium, alopecia areata, tinea capitis, alopecia totalis, hypotrichosis, hereditary hypotrichosis simplex, or alopecia universalis. In one embodiment, the method further comprises the step (b) determining whether the inhibitor administered induced hair growth in the subject afflicted with a hair loss disorder as compared to the subject's hair growth prior to treatment with the inhibitor. In one embodiment, the inhibitor comprises an antibody that specifically binds to a protein comprising SEQ ID NO: 1, 3, 5, 7, 9, or 1. In another embodiment, the inhibitor is an antisense RNA that specifically inhibits expression of the gene that encodes the FGF13 protein; a siRNA that specifically targets the gene that encodes the FGF13 protein, or a small molecule. In one embodiment, the siRNA is directed to a human nucleic acid sequence comprising SEQ ID NO: 2, 4, 6, 8, 10, or 1. In another embodiment, the siRNA directed to a FGF13 gene is any one of the sequences listed in Table 1.

Another aspect of the invention encompasses a method for inducing hair growth in a subject, the method comprising administering to the subject an effective amount of an inhibitor of FGF13, thereby controlling hair growth in the subject. In one embodiment, the subject is afflicted with a hair-loss disorder. In another embodiment, the hair-loss disorder comprises androgenetic alopecia, telogen effluvium, alopecia areata, tinea capitis, alopecia totalis, hypotrichosis, hereditary hypotrichosis simplex, or alopecia universalis. In one embodiment, the method further comprises the step (b) determining whether the inhibitor administered induced hair growth in the subject afflicted with a hair loss disorder as compared to the subject's hair growth prior to treatment with the inhibitor. In one embodiment, the inhibitor comprises an antibody that specifically binds to a protein comprising SEQ ID NO: 1, 3, 5, 7, 9, or 1. In another embodiment, the inhibitor is an antisense RNA that specifically inhibits expression of the gene that encodes the FGF13 protein; a siRNA that specifically targets the gene that encodes the FGF13 protein, or a small molecule. In one embodiment, the siRNA is directed to a human nucleic acid sequence comprising SEQ ID NO: 2, 4, 6, 8, 10, or 1. In another embodiment, the siRNA directed to a FGF13 gene is any one of the sequences listed in Table 1.

Another aspect of the invention encompasses a method of treating a hair-growth disorder in a mammalian subject in need thereof, the method comprising administering to the subject an activator of FGF1. In one embodiment, the hair-growth disorder comprises X-linked hypertrichosis, generalized hypertrichosis terminalis with or without gingival hyperplasia, autosomal recessive hypertrichosis, Cantu syndrome, Ambras type hypertrichosis and autosomal recessive trichomegaly. In one embodiment, the activator is a polypeptide comprising SEQ ID NO: 1, 3, 5, 7, 9, or 11, or a fragment thereof; or a peptidomimetic comprising SEQ ID NO: 1, 3, 5, 7, 9, or 11.

Source:
https://www.google.com/patents/US20150071934

- - - Updated - - -

Another article on FGF13 and hair here:

http://www.ncbi.nlm.nih.gov/pubmed/23603273

 

[2tite2014]

So how long until we get access to the Wolfman treatment?

 

[moskva]

Sigh..It's a shame hundreds of such discoveries ever since the 90s never panned out for public. We deserve much more choices at this spot. Anyway, I do hope hair cloning will finally end this game,the sooner the better.

 

[c_super2]

I don't want to be a negative nancy, but this will take forever to come to market and we don't know if its a cure. I welcome any positive news though. it sounds better than minoxidill though.

 

[abcdefg]

Sounds nifty. Too bad we cant live forever. I dont have 10 years to wait for this.

 

[F2005]

SUMMARY OF THE INVENTION

An aspect of the invention encompasses a method of treating a hair-loss disorder in a mammalian subject in need thereof, the method comprising administering to the subject an inhibitor of FGF1. In one embodiment, the hair-loss disorder comprises androgenetic alopecia, telogen effluvium, alopecia areata, tinea capitis, alopecia totalis, hypotrichosis, hereditary hypotrichosis simplex, or alopecia universalis. In one embodiment, the method further comprises the step (b) determining whether the inhibitor administered induced hair growth in the subject afflicted with a hair loss disorder as compared to the subject's hair growth prior to treatment with the inhibitor. In one embodiment, the inhibitor comprises an antibody that specifically binds to a protein comprising SEQ ID NO: 1, 3, 5, 7, 9, or 1. In another embodiment, the inhibitor is an antisense RNA that specifically inhibits expression of the gene that encodes the FGF13 protein; a siRNA that specifically targets the gene that encodes the FGF13 protein, or a small molecule. In one embodiment, the siRNA is directed to a human nucleic acid sequence comprising SEQ ID NO: 2, 4, 6, 8, 10, or 1. In another embodiment, the siRNA directed to a FGF13 gene is any one of the sequences listed in Table 1.

Another aspect of the invention encompasses a method for inducing hair growth in a subject, the method comprising administering to the subject an effective amount of an inhibitor of FGF13, thereby controlling hair growth in the subject. In one embodiment, the subject is afflicted with a hair-loss disorder. In another embodiment, the hair-loss disorder comprises androgenetic alopecia, telogen effluvium, alopecia areata, tinea capitis, alopecia totalis, hypotrichosis, hereditary hypotrichosis simplex, or alopecia universalis. In one embodiment, the method further comprises the step (b) determining whether the inhibitor administered induced hair growth in the subject afflicted with a hair loss disorder as compared to the subject's hair growth prior to treatment with the inhibitor. In one embodiment, the inhibitor comprises an antibody that specifically binds to a protein comprising SEQ ID NO: 1, 3, 5, 7, 9, or 1. In another embodiment, the inhibitor is an antisense RNA that specifically inhibits expression of the gene that encodes the FGF13 protein; a siRNA that specifically targets the gene that encodes the FGF13 protein, or a small molecule. In one embodiment, the siRNA is directed to a human nucleic acid sequence comprising SEQ ID NO: 2, 4, 6, 8, 10, or 1. In another embodiment, the siRNA directed to a FGF13 gene is any one of the sequences listed in Table 1.

Another aspect of the invention encompasses a method of treating a hair-growth disorder in a mammalian subject in need thereof, the method comprising administering to the subject an activator of FGF1. In one embodiment, the hair-growth disorder comprises X-linked hypertrichosis, generalized hypertrichosis terminalis with or without gingival hyperplasia, autosomal recessive hypertrichosis, Cantu syndrome, Ambras type hypertrichosis and autosomal recessive trichomegaly. In one embodiment, the activator is a polypeptide comprising SEQ ID NO: 1, 3, 5, 7, 9, or 11, or a fragment thereof; or a peptidomimetic comprising SEQ ID NO: 1, 3, 5, 7, 9, or 11.

Source:
https://www.google.com/patents/US20150071934

- - - Updated - - -

Another article on FGF13 and hair here:

http://www.ncbi.nlm.nih.gov/pubmed/23603273

It's too bad that we don't know any FGF1 activators. Then maybe we could get our hands on some and try them out.

 

[abcdefg]

The more of these types of factors involved with hair growth like this, PGD 2, and all these other pathways the more nervous it makes me there will never be a cure for male pattern baldness because its just way too complex with too many relationships. Maybe nothing will ever yields any big results short of what we have now. Short of growing/cloning hairs which IMO will happen decades away when its useless to me.

 

[2tite2014]

Just because there's a lot of factors involved doesn't mean there won't be a cure/super effective treatment. It would just be a matter of combining it all into a hairloss cocktail.

 

[bushbush]

An aspect of the invention encompasses a method of treating a hair-loss disorder in a mammalian subject in need thereof

Mammals eh? I guess that says something about your previous assertion that human and mouse hair biology is nothing alike .

Targeting the protein of a gene such as FGF13 with drugs may be feasible, but the use of RNA interference that this patent partly describes is many years away from clinical application. It is cost prohibitive, may have off-target effects, and will still require repeated applications. The use of siRNA leads to temporary knock-down of expressed products (gene silencing), not knock-out---it therefore currently lends itself more to probing the function of genes in a research environment opposed to treating patients.

 

[ilarry]

http://www.ncbi.nlm.nih.gov/pubmed/23603273