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LATEST ON HAIR CLONING
Hair Multiplication – “Proto Hairsâ€
International Society of Hair Restoration Surgery Annual Meeting, September 2007
The latest development in hair cloning, also called “hair multiplication,†is the production of “Proto-hairs†– tiny, hair-like structures formed in culture by the combination of dermal papilla cells and keratinocytes. This is the basis for the research currently being done by Intercytex, a Cambridge, UK based company with a research laboratory in Boston.
The cells that make up the dermal papillae in a normal hair follicle are called fibroblasts. These cells surround the base of the hair follicle and interact with the epidermal cells of the follicle (the keratinocytes) to regulate the hair cycle and hair growth.
One method of hair cloning has been to inject fibroblasts (that have been multiplied in cell culture) into the skin. The hope is that they will interact with the existing skin cells, particularly the keratinocytes, to induce new hairs to form. This procedure, tried in animal models, has been only modestly successful in producing cosmetically acceptable hair.
In the new procedure, dermal cells and keratinocytes, introduced to each other in a test tube, form small hair-like structures that contain a dermal papilla, matrix and an under-developed hair shaft – a Proto-hair. With the proper conditions, Proto-hairs will take approximately 5 to 7 days to form. When they are implanted back into the skin, visible hairs have appeared in 10-14 days. So far this research has only been performed in animal models.
The name for this new technology, in which cells from a few dermal papillae are expanded in culture to produce cells from which many new follicles can form, is called Follicular Cell Implantation or (FCI). In theory, FCI may be the basis to generate potentially thousands of hair follicles and be used to treat a number of different types of hair loss including male and female pattern alopecia.
However major challenges stand in the way of the rapid development of FCI. The hairs must be of sufficient thickness and must grow to a cosmetically acceptable length, the system of implanting the proto-hair in a human must be developed and be easy to accomplish. Finally, the procedure must be shown to be safe.
Hair Multiplication – “Proto Hairsâ€
International Society of Hair Restoration Surgery Annual Meeting, September 2007
The latest development in hair cloning, also called “hair multiplication,†is the production of “Proto-hairs†– tiny, hair-like structures formed in culture by the combination of dermal papilla cells and keratinocytes. This is the basis for the research currently being done by Intercytex, a Cambridge, UK based company with a research laboratory in Boston.
The cells that make up the dermal papillae in a normal hair follicle are called fibroblasts. These cells surround the base of the hair follicle and interact with the epidermal cells of the follicle (the keratinocytes) to regulate the hair cycle and hair growth.
One method of hair cloning has been to inject fibroblasts (that have been multiplied in cell culture) into the skin. The hope is that they will interact with the existing skin cells, particularly the keratinocytes, to induce new hairs to form. This procedure, tried in animal models, has been only modestly successful in producing cosmetically acceptable hair.
In the new procedure, dermal cells and keratinocytes, introduced to each other in a test tube, form small hair-like structures that contain a dermal papilla, matrix and an under-developed hair shaft – a Proto-hair. With the proper conditions, Proto-hairs will take approximately 5 to 7 days to form. When they are implanted back into the skin, visible hairs have appeared in 10-14 days. So far this research has only been performed in animal models.
The name for this new technology, in which cells from a few dermal papillae are expanded in culture to produce cells from which many new follicles can form, is called Follicular Cell Implantation or (FCI). In theory, FCI may be the basis to generate potentially thousands of hair follicles and be used to treat a number of different types of hair loss including male and female pattern alopecia.
However major challenges stand in the way of the rapid development of FCI. The hairs must be of sufficient thickness and must grow to a cosmetically acceptable length, the system of implanting the proto-hair in a human must be developed and be easy to accomplish. Finally, the procedure must be shown to be safe.
