It's been known probably for 2 decades about fungi's possible contribution in Androgenetic Alopecia so this is just so more information about it.
Investigation on Microecology of Hair Root Fungi in Androgenetic Alopecia Patients.
Huang J1,2, Ran Y3, Pradhan S1, Yan W1, Dai Y4.
Author information
1
Department of Dermatovenereology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China.
2
Department of Dermatovenereology, Medical Center of Dujiang yan, Dujiangyan, 611830, Sichuan Province, China.
3
Department of Dermatovenereology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China. ranyuping@vip.sina.com.
4
Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Abstract
BACKGROUND:
This study focused on the differences in hairy root fungal microecology between androgenetic alopecia patients and healthy individuals.
METHODS:
Light microscopy was used to observe the morphology of hairy roots. Morphological observations were also performed in the positive specimens using scanning electron microscopy and transmission electron microscopy. The high-throughput sequencing method was used to detect the fungal microecology of hairy roots at different sites. Moreover, the comparison of fungal loads of Malassezia in different group and scalp area were tested by PCR.
RESULTS:
The fungi in the hair root observed by optical microscopy are mainly Malassezia yeast. The positive rate of Malassezia in the hair loss group (60%) was higher than that in the control group (40%). The detection efficiency of Malassezia examined by scanning electron microscopy was higher than that by light microscopy. Results acquired from high-throughput molecular sequencing of fungi suggested that Ascomycota was the dominant species, whereas in the occipital hair roots of the control group Basidiomycota was the dominant species in the hair loss group. Malassezia followed by Trichosporon were the most abundant fungal genera. The changes in abundance at the top and occipital region of the control group were more significant than those of the genus Fusarium, followed by Epicoccum and Malassezia. The load of Malassezia located on calvaria in the alopecia group was significantly higher than that in the control group. In the alopecia group, the load of Malassezia on the scalp was higher than that on the occipital region. The load of Malassezia globosa and Malassezia restricta in the hair loss group was higher on calvaria and occipital areas.
CONCLUSION:
Malassezia had a positive correlation with the incidence of androgenic alopecia.
Investigation on Microecology of Hair Root Fungi in Androgenetic Alopecia Patients.
Huang J1,2, Ran Y3, Pradhan S1, Yan W1, Dai Y4.
Author information
1
Department of Dermatovenereology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China.
2
Department of Dermatovenereology, Medical Center of Dujiang yan, Dujiangyan, 611830, Sichuan Province, China.
3
Department of Dermatovenereology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China. ranyuping@vip.sina.com.
4
Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Abstract
BACKGROUND:
This study focused on the differences in hairy root fungal microecology between androgenetic alopecia patients and healthy individuals.
METHODS:
Light microscopy was used to observe the morphology of hairy roots. Morphological observations were also performed in the positive specimens using scanning electron microscopy and transmission electron microscopy. The high-throughput sequencing method was used to detect the fungal microecology of hairy roots at different sites. Moreover, the comparison of fungal loads of Malassezia in different group and scalp area were tested by PCR.
RESULTS:
The fungi in the hair root observed by optical microscopy are mainly Malassezia yeast. The positive rate of Malassezia in the hair loss group (60%) was higher than that in the control group (40%). The detection efficiency of Malassezia examined by scanning electron microscopy was higher than that by light microscopy. Results acquired from high-throughput molecular sequencing of fungi suggested that Ascomycota was the dominant species, whereas in the occipital hair roots of the control group Basidiomycota was the dominant species in the hair loss group. Malassezia followed by Trichosporon were the most abundant fungal genera. The changes in abundance at the top and occipital region of the control group were more significant than those of the genus Fusarium, followed by Epicoccum and Malassezia. The load of Malassezia located on calvaria in the alopecia group was significantly higher than that in the control group. In the alopecia group, the load of Malassezia on the scalp was higher than that on the occipital region. The load of Malassezia globosa and Malassezia restricta in the hair loss group was higher on calvaria and occipital areas.
CONCLUSION:
Malassezia had a positive correlation with the incidence of androgenic alopecia.