is 1.25 mg oral minoxidil better than huge dosage of topical?

[michel sapin]

?

 

[Fontaine]

I'm wondering the same thing man


Perhaps topical minoxidil + microneedling is better than any oral minoxidil

Maybe its not

If oral minoxidil 2.5mg-5mg offers a better aesthetic outcome than topical its a no brainer for me.

 

[vondoom]

most people say you should take 5mg every day...
thats what i am going to do, once that stuff arrives...
well i start with 2.5 and then i up the dose (if i have to)...

my experience with topical hasnt been so good, or lets say unclear... started with kirkland and while that really helped, it gave me the worst rashes i ever had, from scalp down to the eyebrows... so i stopped doing that and used some other brand 7% minoxidil... no improvement at all...
somehow the crown is getting thinner and thinner, but the front is better (or at least stays the same, after huge improvement)...
tried dermarolling for a year, didnt do anything...

so now im going to try oral minoxidil and see if that works... maybe only til that package is empty and then back to topical for maintenance...
or i just stay on oral, since its cheaper anyway...

then i only need to decide to make a complete switch to dutasteride, or first stay on finasteride, but get proscar instead of the generic im using now (finasteride daily and dutasteride every third day at the moment)...

 

[he_who_dares_wins]

I was on a large dose of topical minoxidil, 7% about 5-6 ml each day. A month ago I switched to oral, starting from 1mg and gradually going up to 2.5 mg each day. Around that time I also started topical dutasteride (I've also been on 1.25 mg finasteride for more than a year, so I had already reduced DHT). I got significant hair growth, which I think is from the minoxidil, though I can't be sure, since I also got on dutasteride around the same time. Overall, I think it was a good choice.

 

[Norwoody]

Probably. Oral version produces sulfotransferase which boosts growth exponentially.

If only 1.25mg I still suspect it would be more powerful than topical 5% with dermarolling. It might not be as effective as 15% though. 2.5mg would be more powerful than 15% IMO

 

[Fontaine]

Probably. Oral version produces sulfotransferase which boosts growth exponentially.

If only 1.25mg I still suspect it would be more powerful than topical 5% with dermarolling. It might not be as effective as 15% though. 2.5mg would be more powerful than 15% IMO

I read that there is a variation in how much topical minoxidil can be absorbed systemically

So this can also affect how useful topical is compared to oral

 

[Norwoody]

I read that there is a variation in how much topical minoxidil can be absorbed systemically

So this can also affect how useful topical is compared to oral

Only advantage topical has is obviously decreased side effects. It technically has a longer half life, but oral still has just as long of a half life once it reaches the tissue. It's the local half life that really matters, not serum.

 

[Fontaine]

Only advantage topical has is obviously decreased side effects. It technically has a longer half life, but oral still has just as long of a half life once it reaches the tissue. It's the local half life that really matters, not serum.

If someone wants to switch from topical to oral will they have a worst result than if they started oral first?- what I mean by this does the topical make changes to the scalp that could hinder the orals potential effectiveness

Or does it not matter?

I want to keep oral minoxidil on the sideline as a kind of ace up my sleeve but I hope my current use of topical does not make this an issue

 

[Norwoody]

If someone wants to switch from topical to oral will they have a worst result than if they started oral first?- what I mean by this does the topical make changes to the scalp that could hinder the orals potential effectiveness

Or does it not matter?

I want to keep oral minoxidil on the sideline as a kind of ace up my sleeve but I hope my current use of topical does not make this an issue

I mean, time is certainly of the essence. Oral is sooo much more powerful that I'd recommend anyone to start it ASAP to keep those hairs alive. You can always titrate back for maintenance after you gain desired regrowth. But no, topical doesn't do anything to change the scalp. I went from topical to oral. I also stopped finasteride just after starting oral minoxidil, because OM reduced my shedding dramatically for some reason. I got some regrowth in the first few months and I've maintained it. The thing about OM, unlike most hair loss treatments, is that it will work 99.9% of the time.

 

[Fontaine]

I mean, time is certainly of the essence. Oral is sooo much more powerful that I'd recommend anyone to start it ASAP to keep those hairs alive. You can always titrate back for maintenance after you gain desired regrowth. But no, topical doesn't do anything to change the scalp. I went from topical to oral. I also stopped finasteride just after starting oral minoxidil, because OM reduced my shedding dramatically for some reason. I got some regrowth in the first few months and I've maintained it. The thing about OM, unlike most hair loss treatments, is that it will work 99.9% of the time.

Thing is after only a month and a few days on topical 1.6ml x 2 daily I can see a ridiculous amount of regrowth all over my scalp. I must have the enzyme that allows minoxidil to work topically.

Probably not worth pushing my luck

 

[Norwoody]

Thing is after only a month and a few days on topical 1.6ml x 2 daily I can see a ridiculous amount of regrowth all over my scalp. I must have the enzyme that allows minoxidil to work topically.

Probably not worth pushing my luck

Yeah if it ain't broke don't break it. Like you said, just keep OM in your back pocket if you start losing ground.

 

[trialAcc]

I mean, time is certainly of the essence. Oral is sooo much more powerful that I'd recommend anyone to start it ASAP to keep those hairs alive. You can always titrate back for maintenance after you gain desired regrowth. But no, topical doesn't do anything to change the scalp. I went from topical to oral. I also stopped finasteride just after starting oral minoxidil, because OM reduced my shedding dramatically for some reason. I got some regrowth in the first few months and I've maintained it. The thing about OM, unlike most hair loss treatments, is that it will work 99.9% of the time.

What dose did you start on? Any sides? I'm a complete non-responder to topical so I want to look into it, but bad hearts also run in my family so I want to be abundantly cautious even if my heart is currently fine.

 

[jamesbooker1975]

Can anyone explain me don't simple add tretinoin to the topical solution ? It is already demostrated in vivo that increase the acitvity of the enzyme that convert Minoxidil into minoxidil sulphate ? Why risky with oral when you can do that ? minoxil plus tretinoin will give you even better results than minoxidil oral. It the key combo for most doctors clinics and was popular with the Dr Lee era, so popular, that FDA shoot him down.

 

[he_who_dares_wins]

Can anyone explain me don't simple add tretinoin to the topical solution ? It is already demostrated in vivo that increase the acitvity of the enzyme that convert Minoxidil into minoxidil sulphate ? Why risky with oral when you can do that ? minoxil plus tretinoin will give you even better results than minoxidil oral. It the key combo for most doctors clinics and was popular with the Dr Lee era, so popular, that FDA shoot him down.

Personally, I can't find tretinoin where I live, but if I could, I would give it a try. Nonetheless, oral is far more convenient to use, gives you less skin irritation, which contributes to better and more hair and is also cheaper.

 

[trialAcc]

Can anyone explain me don't simple add tretinoin to the topical solution ? It is already demostrated in vivo that increase the acitvity of the enzyme that convert Minoxidil into minoxidil sulphate ? Why risky with oral when you can do that ? minoxil plus tretinoin will give you even better results than minoxidil oral. It the key combo for most doctors clinics and was popular with the Dr Lee era, so popular, that FDA shoot him down.

Agreed with the post below yours, I honestly can't find tretinoin easily enough and I don't want to start ordering off random pharmacy websites.

 

[N.Y.]

As far as I remember, the transdermal absorption of minoxidil is about 4%. Thus, 2 mg of minoxidil penetrates from 1 ml of 5% solution. Is it correct to assume that 2 mg of oral minoxidil twice a day is the optimal dose?

 

[mm682]

Agreed with the post below yours, I honestly can't find tretinoin easily enough and I don't want to start ordering off random pharmacy websites.

1. Can 1.25mg of Oral Min tablets give you regrowth? I know it's individual, but potentially?

2. Up to how long did it maintain head hair for people at this dosage?

3. How much is the body hair (arms, upper body etc.) increase at 1.25mg?

 

[jamesbooker1975]

Agreed with the post below yours, I honestly can't find tretinoin easily enough and I don't want to start ordering off random pharmacy websites.

You find harder to get tretinoin than oral minoxidil ?!

 

[jamesbooker1975]

Personally, I can't find tretinoin where I live, but if I could, I would give it a try. Nonetheless, oral is far more convenient to use, gives you less skin irritation, which contributes to better and more hair and is also cheaper.

Yes, but oral have tons of more side effects .

 

[he_who_dares_wins]

Yes, but oral have tons of more side effects .

After 1 month of use at 2.5 mg I have very few side effects and possibly less than what I did with a large dose of topical.
I can't get my hands on legit loniten, so I ingest liquid minoxidil which I mix myself from powder, instead.