No, no no no no no no no it does not work. Propecia works, minoxidil works, Nizoral works. Nioxin is a big pile of sh*t, I used it for years with no results and then jumped on the Big 3, which is now working great for me.
I was running out of Nioxin and was at the point where I was questioning their product. I e-mailed them and asked if they would be willing to send me some free product to keep me a customer. They basically told me to f*** off. Not a sign of a customer friendly company that is concerned about the veracity of their product.
I'm not bitter, I just know snake-oil when I see it. Nioxin is a about as flaky as it comes. Expensive and ineffectual.