Is there any good evidence for the efficacy of folligen?

[mgdpublic]

I've been using this stuff and decided to look into it more and I can't find a single medline study that includes copper/peptides helping scalp. As a matter of fact the only place I found anything about it was on their website. Most of their evidence seemed to deal with the binding effects of recent grafts rather than normal or even inflamed scalp tissue. It says it's used to treat scalp dermatitis but no where on the internet can I find references. I'm beginning to think that any benefits from this stuff is because your applying a lotion directly to your scalp. Lubriderm would probably work just as well. Any comments?

 

[dave01_us]

I dont know about any studies,but alot of people swear by the stuff as for myself i cant say its helped with any regrowth but it has definately calmed my scalp down and eased the itching

 

[Guest]

I've been using this stuff and decided to look into it more and I can't find a single medline study that includes copper/peptides helping scalp. As a matter of fact the only place I found anything about it was on their website. Most of their evidence seemed to deal with the binding effects of recent grafts rather than normal or even inflamed scalp tissue. It says it's used to treat scalp dermatitis but no where on the internet can I find references. I'm beginning to think that any benefits from this stuff is because your applying a lotion directly to your scalp. Lubriderm would probably work just as well. Any comments?

Dr. Pickard was the guy who invented tricomin. This substance cleared FDA trial #2 (if memory serves) back a decade or so ago. They did not pursue final FDA trial as they did not have the $$$$ as the story goes.

Pickard sold tricomin and started skin biology. There are studies dating somewhere around 1995 in Jagan on copper peptides and hair growth. Obscure and I dont have cites.

HairLossTalk.com may have more to add on this.

 

[Guest]

So would the folligen conditioner stimulate hair growth?

 

[Guest]

So would the folligen conditioner stimulate hair growth?

Dr. Pickard does not claim that. To the degree that copper peptides do stimulate hair growth, the shampoo and conditioner both have them.

It is a crap shoot. I like the shampoo and conditioner for what they do cosmetically.

 

[mgdpublic]

So would the folligen conditioner stimulate hair growth?

I think the idea is that it helps maintain a healthy scalp and that the follicles increase in size.

 

[RalphyWiggum]

I've been using this stuff and decided to look into it more and I can't find a single medline study that includes copper/peptides helping scalp. As a matter of fact the only place I found anything about it was on their website. Most of their evidence seemed to deal with the binding effects of recent grafts rather than normal or even inflamed scalp tissue. It says it's used to treat scalp dermatitis but no where on the internet can I find references. I'm beginning to think that any benefits from this stuff is because your applying a lotion directly to your scalp. Lubriderm would probably work just as well. Any comments?

I think you want to discuss this with Bryan as he is the formost expert and possessor of cu pepide literature...

 

[mgdpublic]

I think you want to discuss this with Bryan as he is the formost expert and possessor of cu pepide literature...

Is he on the board?

 

[Bryan]

Here's a question put to me last year on alt.baldspot about SODs, and my reply. It's not about Folligen specifically, but about copper peptides and hair growth in general. I'll have some additional comments afterwards:


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On Tue, 09 Jul 2002 02:00:16 GMT, honkguy <honkguy@hotmail.com> wrote:

>> >BTW, show me one shred of clinical evidence that SODs grow hair on male pattern baldness
>> >sufferers. Don't pull out the "clinical trials" from ProCyte, either, because
>> >I believe those results about as much as I believe Springhair Tonic works.
>>
>> Why do you feel that way, Mitch? I've previously cited three studies
>> on SODs that were published in a medical journal;
>
>For male pattern baldness? Could you posts the references if you get a chance?

Oops... I goofed. They weren't published in a medical journal, they were published in the book "Dermatologic Research Techniques", CRC Press, 1996.

They are three consecutive chapters in the book:

Chapter 16: "Phototrichogram Analysis of Hair Follicle Stimulation: A Pilot Clinical Study with a Peptide-Copper Complex" Ronald E. Trachy, Leonard M. Patt, Gordon M. Duncan, and Bernard Kalis. This was done on *human* subjects with male pattern baldness. Both total and anagen hair density increased significantly (anagen hair: +39%) with the larger topical dose of copper-peptide (glycyl-histidine-lysine-valine-phenyalanine-valine), especially when compared to total and anagen hair density LOSSES in the placebo-treated group.

Chapter 17: "Quantitative Assessment of Peptide-Copper Complex-Induced Hair Follicle Stimulation Using the Fuzzy Rat" Ronald E. Trachy, Hideo Uno, Shelley Packard, and Leonard M. Patt. This was done on rats. Copper peptides significantly stimulated hair growth, compared to vehicle.

Chapter 18: "Evaluation of Telogen Hair Follicle Stimulation Using an In Vivo Model: Results with peptide-Copper Complexes" Ronald E. Trachy, Erika D. Timpe, Irene Dunwiddie, and Leonard M. Patt. This was on mice. Copper peptides significantly stimulated hair growth in mice, compared to vehicle; it also exceeded the growth induced by 2% topical minoxidil, which was also tested.
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Notice that the above studies were published in a dermatology book, not a peer-reviewed journal, as was requested by the poster earlier in this thread. However, Dr. Hideo Uno (BTW, that's the same Dr. Uno who's famous for his experiments with topical RU58841 in balding stumptailed macaques!) also published an article in a MAJOR dermatology journal (The Journal of Investigative Dermatolgy) about his results with the copper-peptide (among other agents) from that Chapter 17 study above. Here is the citation for that separate peer-reviewed journal article: "Chemical Agents and Peptides Affect Hair Growth", Uno et al, J Invest Dermatol 101: 143S-147S, 1993.

Bryan

 

[Guest]

Good stuff. Thanks Bryan.

 

[bombscience]

Yes thanks Bryan, please come around here more often, there is tons to learn from you.

 

[RalphyWiggum]

Yep I think I'm going to change my signature to "thank you bryan and/or Bruce"