Ive Read That Pge2 Is Slightly Lower In Problem Scalps.......does..

[proscar2]

anyone have any proof that confirms this? and does this not suggest that there at least 'MAY' be a window or ratio regarding pdg2 and pge2 rather than just concentrating on seti? if you actually examine westonci's regimen he is actually using PGE2. i wonder if that's why hes getting such results.

Also noted in this this study, suggested a balance also:
This was also noted in the original Garza et al., paper (Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.) for aspirin:
"Our results suggest that in mouse and human skin, a balance between PGE2 and PGD2 controls hair growth. This model predicts then that efforts to reverse alopecia should optimally focus on both enhancing PGE2 and inhibiting PGD2 signaling. (**ONLY WESTONCI IS DOING THIS!!!)This model also explains why agents such as aspirin, which inhibit upstream prostaglandin synthesis enzymes (PTGS1 and PTGS2), have minimal effects on hair growth because of likely equally decreased production of PGE2 and PGD2."


someone posted this on a forum some time back :-
If I remember well in the Cotstarelis' study, PGD2 levels in a bald scalp are much more "abnormal" than PGE2 levels (which are a little bit lower than the ones in a non balding scalp).. Westonci is the only one actually RAISING PGE2 as well and not just inhibiting pdg2!!

if the above is true then surely the pge2 needs to be increased somewhat? and maybe this may be contributing towards all this shedding? is anyone else using pge2?



EDIT- Unbelievable someones just posted (westonci comments ) that has took the words from my mouth regarding this actual point!!! seems PGE2 is essential and therefore indicates there is a balance/ ratio/ window as indicated in the original study?

 

[cretin]

was premise of original "swisstemples" user

PGE2 needs increase
PGD2 needs decrease

only one = maintain at best
both = regrowth

 

[proscar2]

so why the hell are people moaning about seti

 

[proscar2]

wests added pge2 and started dermarolling and his results seem to have exploded. see his images. it seems its needed

 

[kiwipilu]

We know pge2 is the good, pgd2 is the bad. NOW the ugly part is to find the correct balance like you say. We just can't inhibit 100%. norwood 0 also have pgd2 in their scalp.
I wonder if too powerful pgd2 inhibitor could make more harm than good...

 

[buckthorn]

the real question is - what's worst? a) being bald or b) keeping up with all this anecdotal f*****g bullshit. can you honestly answer me this question?

 

[Dennis Garber]

I would say, C. Trying to hurriedly skip, irrelevant posts.

Anecdotes and studies must, both, be taken with a grain of salt. Often the studies are obviously overlooking blatantly obvious variables, that the scientists generally overlook. I don't drink water because of studies, I drink because of anecdotal evidence. In fact, the anecdotal support is so strong that water quenches thirst, studies are not needed. Might be worth trying to get grant money to prove.