JohnnySeville
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It is common for a percentage of Finasteride users to discontinue therapy for numerous reasons, mainly sexual sides. A number of guys are rightly concerned about the loss of any hair growth that may result from cessation of Finasteride. I have come across this study which indicates Aminexil, can be used successfully to retain the resultant hair growth in a high percentage of users. Something to consider if you must stop using Finasteride. This may even be applicable to Dutasteride users, though no study has been made as of yet.
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Colombina Vincenzi, Alfredo Rossi*,Carmen Cantisani*, Massimiliano Pazzaglia, Antonella Tosti
Department of Dermatology, University of Bologna, Italy, * Department of Dermatology , University La Sapienza, Rome, Italy
The aim of this study was to evaluate whether topical treatment with Aminexil lotion would prevent or reduce hair loss which usually occurs after discontinuation of oral finasteride treatment.
The study involved 18 male patients aged from 20 to 43 years (median age 30.03) affected by androgenetic alopecia (Hamilton/Norwood classification scale IIv – IV) who had been successfully treated with finasteride 1 mg for at least 1 year. All these patients had decided to stop finasteride intake because of side effects or personal reasons. They all applied Aminexil lotion once daily for one year until completion of the study. Assessment was carried out using hair counts (obtained from color macrophotograph of an area 2,2 cm2 in diameter) and standardized global photograph of the anterior/mid region of the scalp taken at the baseline (phase 0), after 6 months (phase 1) and at the end of the study (phase 2). After 1 year of Aminexil treatment, the mean hair count decreased by 30 ± 44 hairs. However an increase in hair count was found in 3 patients. Evaluation from global photographs showed a moderate decrease in 3 patients, a slight decrease in 6 patients and no changes in the remaining 9 patients.
The present study suggests that Aminexil may be helpful in preventing hair loss after stopping finasteride treatment. Further studies on a large number of patients are needed to confirm these preliminary results.
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Colombina Vincenzi, Alfredo Rossi*,Carmen Cantisani*, Massimiliano Pazzaglia, Antonella Tosti
Department of Dermatology, University of Bologna, Italy, * Department of Dermatology , University La Sapienza, Rome, Italy
The aim of this study was to evaluate whether topical treatment with Aminexil lotion would prevent or reduce hair loss which usually occurs after discontinuation of oral finasteride treatment.
The study involved 18 male patients aged from 20 to 43 years (median age 30.03) affected by androgenetic alopecia (Hamilton/Norwood classification scale IIv – IV) who had been successfully treated with finasteride 1 mg for at least 1 year. All these patients had decided to stop finasteride intake because of side effects or personal reasons. They all applied Aminexil lotion once daily for one year until completion of the study. Assessment was carried out using hair counts (obtained from color macrophotograph of an area 2,2 cm2 in diameter) and standardized global photograph of the anterior/mid region of the scalp taken at the baseline (phase 0), after 6 months (phase 1) and at the end of the study (phase 2). After 1 year of Aminexil treatment, the mean hair count decreased by 30 ± 44 hairs. However an increase in hair count was found in 3 patients. Evaluation from global photographs showed a moderate decrease in 3 patients, a slight decrease in 6 patients and no changes in the remaining 9 patients.
The present study suggests that Aminexil may be helpful in preventing hair loss after stopping finasteride treatment. Further studies on a large number of patients are needed to confirm these preliminary results.
They say that after 1 year of aminexil, haircounts dropped by an average of 30 hairs. They don't say whether that's relative to the start of finasteride treatment or relative to the start of aminexil treatment, but I'm going to assume that it's the latter. In the large Propecia phase III trial, subjects who were switched over to placebo after 1 year of finasteride lost about 115 hairs after an additional year, so it seems reasonable to assume that the guys in this study probably saved about 115 - 30 = 85 hairs while on aminexil. If this is reasonably accurate, then this doesn't speak very well for aminexil, since minoxidil performance (based on haircounts) is generally much better than that!!
