lets talk bout Nizoral's anti DHT properties

hate2shed

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dudes how weak are nizorals anti androgenic properties
how much DHT , percentage wise can it eluminate?
i use it 3 times a week and i think i shed less when i use it

thanks for replies :roll:
 

VoRteX

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Ketoconazole has been proven to decrease the quantities of DHT in the scalp by helping to inhibit its synthesis from sterols

from Dr. Lee's site.

this is conjecture on Dr. Lee's part, IMHO. It probably has some beneficial effect but dont count on it to stopyour male pattern baldness alone.
 
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vortex72--> said:
Ketoconazole has been proven to decrease the quantities of DHT in the scalp by helping to inhibit its synthesis from sterols

from Dr. Lee's site.

this is conjecture on Dr. Lee's part, IMHO. It probably has some beneficial effect but dont count on it to stopyour male pattern baldness alone.

Whats Dr. Lees site - I want to take a look...thanks
 

hate2shed

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vortex72--> said:
Ketoconazole has been proven to decrease the quantities of DHT in the scalp by helping to inhibit its synthesis from sterols

from Dr. Lee's site.

this is conjecture on Dr. Lee's part, IMHO. It probably has some beneficial effect but dont count on it to stopyour male pattern baldness alone.

Well even if it kills some dht that will do for me :)
 

Bryan

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Dr. Lee mentions that ketoconazole can apparently help inhibit the synthesis of androgens or their precursors (I'm still not sure just how important that is for topical application to hair follicles), but he has never acknowledged that it also has an androgen receptor blocking ability, albeit a very mild one. I even once sent him a citation for the study that found that, but he still never mentions it.

Bryan
 

HairlossTalk

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Welcome back Bryan! (Kotter)

HairLossTalk.com
 

maddoc23

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Nizoral will not inhibit any DHT because it does not stay on the scalp long enough to penetrate the skin.

D
 
G

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hate2shed said:
what if u rub it into your temples and leave it for a nite
?

Actually there is a topical ointment with the active ingredient of nizoral available. No research on whether it would impact hair growth etc. that I know of.

:lol:
 

maddoc23

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Hate2shed,

I think you are missing the point. The action of nizoral to abate hairloss is from its anti-fungal properties NOT its anti-androgenic. For nizoral to be effective as an anti-fungal you only need to use it as directed. Other than taking it orally, it is unknown how to apply it topically to be effective as an anti-androgenic. Keep in mind, if you take it (ketoconazole) orally or plan it absorb it through the scalp (if possible) you are open to side effects.

D
 

Bryan

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maddoc23 said:
Nizoral will not inhibit any DHT because it does not stay on the scalp long enough to penetrate the skin.

Really? How do you explain the fact that sebaceous glands were reduced in size by almost 20% in the famous Nizoral male pattern baldness study?

Bryan
 
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Bryan said:
maddoc23 said:
Nizoral will not inhibit any DHT because it does not stay on the scalp long enough to penetrate the skin.

Really? How do you explain the fact that sebaceous glands were reduced in size by almost 20% in the famous Nizoral male pattern baldness study?

Bryan

Bryan, mind if I pile on?

Yes, how DO you explain that?

:freaked:
 

hate2shed

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BruceLee said:
Bryan said:
maddoc23 said:
Nizoral will not inhibit any DHT because it does not stay on the scalp long enough to penetrate the skin.

Really? How do you explain the fact that sebaceous glands were reduced in size by almost 20% in the famous Nizoral male pattern baldness study?

Bryan

Bryan, mind if I pile on?

Yes, how DO you explain that?

:freaked:

Bryan, Bruce lee, mind if I pile on?
Yes HOW DO U EXPLAIN THAT?
:lol:
 

maddoc23

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Bruce and Bryan,

Nizoral treats Seborrheic Dermatitis, which is characterized by an excessive amount of sebum production. Is it surprising that nizoral would then shrink the sebaceous gland. After all it is an anti-inflammatory.

D
 

Bryan

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maddoc23 said:
Bruce and Bryan,

Nizoral treats Seborrheic Dermatitis, which is characterized by an excessive amount of sebum production. Is it surprising that nizoral would then shrink the sebaceous gland. After all it is an anti-inflammatory.

Maddoc, that answer sounds a little too pat and opportunistic to me, because I'm not aware that anti-inflammatory agents per se shrink sebaceous glands. If you can find any evidence that they do, I'll certainly accept it; but for now, I think the simplest and best explanation (let's use Occam's Razor! :)) is that Nizoral shrinks sebaceous glands by virtue of its mild antiandrogenic properties.

Bryan
 
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