Light controllable drugs for hair loss (PHOTACS)

[FollicleGuardian]

By compounding chemicals into an azobenzene skeleton, the chemicals display little or no activity in the dark but can be reversibly activated with different wavelengths of light. The modular approach provides a method for the optical control that could lead to new types of precision therapeutics that avoid undesired systemic toxicity.

In short, the drug is only activated by light. And is ineffective even if it goes systemic. What if we combined a PHOTAC anti androgen, 5-a inhibitor, AR degrader or even a Estrogen receptor agonist with infrared lights from laser helmets?

Science | AAAS

advances.sciencemag.org

https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.8b01631

Thoughts?

 

[FollicleGuardian]

The light switch technique can also be used with gene editing: «crRNA/tracrRNA duplex (guide RNA or gRNA) with photocaging groups, preventing the gRNA from recognizing its genome target sequence until its deprotection is induced within seconds of illumination.»

 

[FollicleGuardian]

@pegasus2 Any input on this?

 

[pegasus2]

It looks interesting, but I haven't read it yet. I'll try to get to it this week.

 

[FollicleGuardian]

It looks interesting, but I haven't read it yet. I'll try to get to it this week.

Thank you mate! Your knowledge level is world class so very much appreciated.