Lipid peroxides induce early onset of catagen phase

[bornthisway]

Lipid peroxides induce early onset of catagen phase in murine hair cycles

Int J Mol Med. 2008 Dec;22(6):725-729.

Biological Science Research Laboratories, Research and Development Headquarters, LION Corporation, 100 Tajima, Kanagawa 256-0811, Japan.

The precise mechanisms of alopecia, a pathophysiological disorder with negative psychological implications, are unknown. Androgen and hereditary predisposition are major causes, but the condition is also affected by stress, an irregular diet and high levels of sebum secretion. We focused on oxidative stress and analyzed the effect of the lipid peroxides on hair follicles. Our first observation was that the topical application of linolein hydroperoxides, one of the lipid peroxides, lead to the early onset of the catagen phase in murine hair cycles. Furthermore, by using TUNEL staining we found that lipid peroxides induced apoptosis of hair follicle cells. They also induced apoptosis in human epidermal keratinocytes by up-regulating apoptosis-related genes. These results indicated that lipid peroxides, which can cause free radicals, induce the apoptosis of hair follicle cells, and this is followed by early onset of the catagen phase. These observations may provide insight into the mechanisms underlying the development of alopecia in humans.

 

[Armando Jose]

Hi Bornthisway

Thank you for the input, ¿Is it possible get the complete study?

Have a nice day

Armando

 

[purecontrol]

That is why SOD and things like Chocamine work!

 

[bornthisway]

Hi Bornthisway

Thank you for the input, ¿Is it possible get the complete study?

Have a nice day

Armando

Hey Armando, I haven't been very active on forums since this Spring but I will check all of the resources I have access to and see if I can get a copy. If anyone can find it in the meanwhile feel free to post it. LION has produced quite a few studies related to hair loss (re: ephrin-a3) and have developed products based on their studies... unfortunately so far according to experiences I've read here they have been ineffective.

 

[squeegee]

Bump this **** up!!

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Androgens affect the activity of human sebocytes in culture in a
manner dependent on the localization of the sebaceous glands and their
effect is antagonized by spironolactone.
======================================================================
Author
Zouboulis CC; Akamatsu H; Stephanek K; Orfanos CE
Address
Department of Dermatology, University Medical Center Steglitz, Free
University of Berlin,
FRG.
Source
Skin Pharmacol, 7(1-2):33-40 1994
Abstract
To investigate the varying response of the pilosebaceous unit to
androgens functional studies
were performed on the effects of testosterone and 5
alpha-dihydrotestosterone on cultured
human sebocytes derived from different skin regions. In addition, the
effect of
spironolactone on the proliferation of androgen-stimulated human
sebocytes derived from
facial skin was evaluated. Testosterone (10(-11) to 10(-5) M), 5
alpha-dihydrotestosterone
(10(-11) to 10(-5) M) and spironolactone (10(-12) to 10(-7) M) were
added for 10 days
as single substances or in combinations to human sebocytes in
secondary culture maintained
in a serum-free medium. Cell proliferation was assessed using a
fluorometric assay.
Intracellular lipids were extracted from sebocytes treated with
androgens (10(-7) M) for 10
days after confluency. Testosterone inhibited the proliferation of
sebocytes derived from the
legs with a 50%-inhibitory concentration at 10(-5) M and induced a 50%
decrease of
intracellular lipids. In contrast, 5 alpha-dihydrotestosterone
stimulated the activity of leg
sebocytes with a 50% increase of proliferation at 10(-5) M, and a 175%
increase of
intracellular lipids. On the other hand, the proliferation of facial
sebocytes was significantly
stimulated by testosterone with a 50%-stimulatory concentration at
10(-6) to 10(-5) M and
mostly by 5 alpha-dihydrotestosterone with a 50% enhancement at 10(-8)
to 10(-7) M.
Spironolactone inhibited the proliferation of facial sebocytes in a
dose-dependent manner
with a 25%-inhibitory concentration at 10(-9) M. Simultaneous
treatment of facial sebocytes
with spironolactone and testosterone or 5 alpha-dihydrotestosterone
resulted in decreased
proliferation when compared to the growth obtained under androgens
alone

 

[Armando Jose]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136571/

[h=1]tert-Butyl hydroperoxide, an organic peroxide, causes temporary delay in hair growth in a neonatal rat model[/h]

It is possible a link between peroxides lipids and the predisposition of hairloss

 

[Armando Jose]

http://www.spandidos-publications.com/ijmm/22/6/725/abstract Here is the full study, where concluded that lipid peroxidation may play a role in hairloss. Coments are wellcome