I'm in search to try the natural way, but hard to choose which one and dosage. Is anyone already trying something? or have infos from others and can help?
This march 2016 study is interesting as it list all our options
http://www.bdjn.org/Journal_Prv_View.html?j_sub_num=51 "Natural products targeting STAT3 signaling pathways in cancer cells"
In the full text study they explain in detail for each natural product the mechanism that lead to the stat3 activity inhibition (various angles, even in same category)
________________________________________
MODULATION OF STAT3 ACTIVITY BY KINASE INHIBITION
-Brevilin A
-Cucurbitacin B
-JSI-124
-Methoxydalbergione (4-MD)
-Curcumin
-Thymoquinone (TQ)
INHIBITION OF STAT3 ACTIVITY BY PHOSPHATASES
-Acetoxychavicol acetate (ACA)
-Guggulsterone (GS)
-Hydroxy-2-methyl-1,4-naphthoquinone (plumbagin)
-Farnesol (FOH)
-Capillarisin (CPS)
MODULATION OF STAT3 ACTIVITY THROUGH ROS
-Nimbolide (NL)
-Shogaol (6SG)
-Sugiol
DIRECTLY TARGETING STAT3 PROTEIN
-Cryptotanshinone (CTS)
-Alantolactone
-Scoparone (6,7-dimethoxycoumarin)
_________________________________________________
I will try from two angles I think, the kinase inhibition and one of the other 3. But for now I need to search more on those products to find safe dosages for a topical application. Please let me know if you already have infos about that or advices, thanks!
This march 2016 study is interesting as it list all our options
http://www.bdjn.org/Journal_Prv_View.html?j_sub_num=51 "Natural products targeting STAT3 signaling pathways in cancer cells"
In the full text study they explain in detail for each natural product the mechanism that lead to the stat3 activity inhibition (various angles, even in same category)
________________________________________
MODULATION OF STAT3 ACTIVITY BY KINASE INHIBITION
-Brevilin A
-Cucurbitacin B
-JSI-124
-Methoxydalbergione (4-MD)
-Curcumin
-Thymoquinone (TQ)
INHIBITION OF STAT3 ACTIVITY BY PHOSPHATASES
-Acetoxychavicol acetate (ACA)
-Guggulsterone (GS)
-Hydroxy-2-methyl-1,4-naphthoquinone (plumbagin)
-Farnesol (FOH)
-Capillarisin (CPS)
MODULATION OF STAT3 ACTIVITY THROUGH ROS
-Nimbolide (NL)
-Shogaol (6SG)
-Sugiol
DIRECTLY TARGETING STAT3 PROTEIN
-Cryptotanshinone (CTS)
-Alantolactone
-Scoparone (6,7-dimethoxycoumarin)
_________________________________________________
I will try from two angles I think, the kinase inhibition and one of the other 3. But for now I need to search more on those products to find safe dosages for a topical application. Please let me know if you already have infos about that or advices, thanks!
