HairlossCurse
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https://academiccommons.columbia.edu/doi/10.7916/D8SX7RQN (quote at bottom, this is full PhD thesis from AM Christianos lab)
Smaller paper: https://www.ncbi.nlm.nih.gov/pubmed/30930146 (does anyone have access and can upload the pdf?)
Basically, they found that there is a dermis-resident TREM2+ macrophage subpopulation that promotes hair follicle stem cell quiescence (quiescence = dormant/resting), which in turn, inhibits hair growth via cytokine-mediated JAK-STAT signaling.
Based from abstract of the thesis (thesis not available yet), the macrophages and Oncostatin M (OSM) were found to be up-regulated in the bald scalp of Androgenetic Alopecia patients.
The JAK-STAT inhibitors block this, meaning it could be that topical JAK-STAT inhibitors may work for Androgenetic Alopecia, here is hoping.
Aclaris therapeutics is due to release data from their Androgenetic Alopecia trail this quarter. If JAK-STAT doesnt work, I am just going to concede and get a hair transplant...ha
Smaller paper: https://www.ncbi.nlm.nih.gov/pubmed/30930146 (does anyone have access and can upload the pdf?)
Basically, they found that there is a dermis-resident TREM2+ macrophage subpopulation that promotes hair follicle stem cell quiescence (quiescence = dormant/resting), which in turn, inhibits hair growth via cytokine-mediated JAK-STAT signaling.
Based from abstract of the thesis (thesis not available yet), the macrophages and Oncostatin M (OSM) were found to be up-regulated in the bald scalp of Androgenetic Alopecia patients.
The JAK-STAT inhibitors block this, meaning it could be that topical JAK-STAT inhibitors may work for Androgenetic Alopecia, here is hoping.
Aclaris therapeutics is due to release data from their Androgenetic Alopecia trail this quarter. If JAK-STAT doesnt work, I am just going to concede and get a hair transplant...ha