Masturbation MUST stop.

[ripple-effect]

Articles
Endocrine effects of masturbation in men
K Purvis, BM Landgren, Z Cekan, and E Diczfalusy


The levels of pregnenolone, dehydroepiandrosterone (DHA), androstenedione, testosterone, dihydrotestosterone (DHT), oestrone, oestradiol, cortisol and luteinizing hormone (LH) were measured in the peripheral plasma of a group of young, apparently healthy males before and after masturbation. The same steroids were also determined in a control study, in which the psychological antipation of masturbation was encouraged, but the physical act was not carried out. The plasma levels of all steroids were significantly increased after masturbation, whereas steroid levels remained unchanged in the control study. The most marked changes after masturbation were observed in pregnenolone and DHA levels. No alterations were observed in the plasma levels of LH. Both before and after masturbation plasma levels of testosterone were significantly correlated to those of DHT and oestradiol, but not to those of the other steroids studied. On the other hand, cortisol levels were significantly correlated to those of pregnenolone, DHA, androstenedione and oestrone. In the same subjects, the levels of pregnenolone, DHA, androstenedione, testosterone and DHT in seminal plasma were also estimated; they were all significantly correlated to the levels of the corresponding steroid in the systemic blood withdrawn both before and after masturbation. As a practical consequence, the results indicate that whenever both blood and semen are analysed, blood sampling must precede semen collection.

http://joe.endocrinology-journals.org/c ... t/70/3/439

 

[ripple-effect]

Re: Masturbation must stop

I think masturbation itself increaes the sex drive as your body adapts to the routine and therefore more and more testosterone is made to keep up with the demand and this will evnetually turn intodht which will make the hair loss case worse.Try something like spearmint tea to lower your sex drive and you might end up lowering your frequency ofmasturbation which will reduce the production of dht ad your hair may have a chance of rejuvenating itself.

- by Jezz (opinion)

http://www.baldingblog.com/2006/01/03/m ... s/#respond

 

[docj077]

Oops...


: Physiol Res. 2006;55(4):429-36. Epub 2005 Oct 17. Links
Circulating neuroactive C21- and C19-steroids in young men before and after ejaculation.Stárka L, Hill M, Havlíková H, Kancheva L, Sobotka V.
Institute of Endocrinology, Prague, Czech Republic. lstarka@endo.cz

Twelve neuroactive and neuroprotective steroids, androgens and androgen precursors i.e. 3alpha,17beta-dihydroxy-5alpha-androstane, 3alpha-hydroxy-5alpha-androstan-17-one, 3alpha-hydroxy-5beta-androstan-17-one, androst-5-ene-3beta,17beta-diol, 3beta,17alpha-dihydroxy-pregn-5-en-20-one (17alpha-hydroxy-pregnenolone), 3beta-hydroxy-androst-5-en-17-one (dehydroepiandrosterone, DHEA), testosterone, androst-4-ene-3,17-dione (androstenedione), 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone), 3beta-hydroxy-pregn-5-en-20-one (pregnenolone), 7alpha-hydroxy-DHEA, and 7beta-hydroxy-DHEA were measured using the GC-MS system in young men before and after ejaculation provoked by masturbation. The circulating level of 17alpha-hydroxypregnenolone increased significantly, whereas the other circulating steroids were not changed at all. This fact speaks against the hypothesis that a drop in the level of neuroactive steroids, e.g. allopregnanolone may trigger the orgasm-related increase of oxytocin, reported by other authors.


Neither androgens or potent androgen precursors were elevated in this study.


It is a very good idea to find research that has been done from this decade or the late nineties. Technology has changed too much and our ability to differentiate bound from unbound hormone has really changed how we approach endocrinology.

 

[ripple-effect]

1: J Zhejiang Univ Sci. 2003 Mar-Apr;4(2):236-40.Click here to read Links
A research on the relationship between ejaculation and serum testosterone level in men.
Jiang M, Xin J, Zou Q, Shen JW.

Department of Life Science, Hangzhou Normal College, Hangzhou 310020, China. jiangmy@mail.hz.zj.cn

The purpose of this study is to gain understanding of the relationship between ejaculation and serum testosterone level in men. The serum testosterone concentrations of 28 volunteers were investigated daily during abstinence periods after ejaculation for two phases. The authors found that the fluctuations of testosterone levels from the 2nd to 5th day of abstinence were minimal. On the 7th day of abstinence, however, a clear peak of serum testosterone appeared, reaching 145.7% of the baseline ( P < 0.01). No regular fluctuation was observed following continuous abstinence after the peak. Ejaculation is the precondition and beginning of the special periodic serum testosterone level variations, which would not occur without ejaculation. The results showed that ejaculation-caused variations were characterized by a peak on the 7th day of abstinence; and that the effective time of an ejaculation is 7 days minimum. These data are the first to document the phenomenon of the periodic change in serum testosterone level; the correlation between ejaculation and periodic change in the serum testosterone level, and the pattern and characteristics of the periodic change.

PMID: 12659241 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/1265 ... t=Abstract

Researchers found that abstaining from ejaculation for six days had no impact on serum testosterone levels. On the seventh day, serum testosterone levels peaked to 145.7% of baseline, and then declined rapidly on the eighth day.

Researchers believe testosterone declined on day eight from the negative feedback suppression of Leutinizing hormone secretion. Leutinizing hormone is essential for testosterone production, and LH determines free testosterone levels. Suppression of LH would decrease serum testosterone levels, returning them to baseline. The study determined that the frequency of sexual activity and ejaculation impacted testosterone levels.

http://www.bodybuilding.com/fun/south99.htm

 

[ripple-effect]

1: Reprod Biol Endocrinol. 2007 Mar 16;5:11.Click here to read Click here to read Links
A study of the prostate, androgens and sexual activity of male rats.
Hernandez ME, Soto-Cid A, Aranda-Abreu GE, Díaz R, Rojas F, Garcia LI, Toledo R, Manzo J.

Instituto de Neuroetologia, Universidad Veracruzana, Xalapa, Ver., Mexico. elenahernandez@uv.mx

BACKGROUND: The prostate is a sexual gland that produces important substances for the potency of sperm to fertilize eggs within the female reproductive tract, and is under complex endocrine control. Taking advantage of the peculiar behavioral pattern of copulating male rats, we developed experimental paradigms to determine the influence of sexual behavior on the level of serum testosterone, prostate androgen receptors, and mRNA for androgen receptors in male rats displaying up to four consecutive ejaculations. METHODS: The effect of four consecutive ejaculations was investigated by determining levels of (i) testosterone in serum by solid phase RIA, (ii) androgen receptors at the ventral prostate with Western Blots, and (iii) androgen receptors-mRNA with RT-PCR. Data were analyzed with a one-way ANOVA followed by a post hoc application of Dunnett's test if required. RESULTS: The constant execution of sexual behavior did not produce any change in the weight of the ventral prostate. Serum testosterone increased after the second ejaculation, and remained elevated even after four ejaculations. The androgen receptor at the ventral prostate was higher after the first to third ejaculations, but returned suddenly to baseline levels after the fourth ejaculation. The level of mRNA increased after the first ejaculation, continued to increase after the second, and reached the highest peak after the third ejaculation; however, it returned suddenly to baseline levels after the fourth ejaculation. CONCLUSION: Four consecutive ejaculations by sexually experienced male rats had important effects on the physiological responses of the ventral prostate. Fast responses were induced as a result of sexual behavior that involved an increase and decrease in androgen receptors after one and four ejaculations, respectively. However, a progressive response was observed in the elevation of mRNA for androgen receptors, which also showed a fast decrease after four ejaculations. All of these changes with the prostate gland occurred in the presence of a sustained elevation of testosterone in the serum that started after two ejaculations. A consideration of these fast-induced changes suggests that the nerve supply plays a key role in prostate physiology during the sexual behavior of male rats.

PMID: 17367532 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/1736 ... d_RVDocSum

BACKGROUND: The prostate is a key gland in the sexual physiology of male mammals. Its sensitivity to steroid hormones is widely known, but its response to prolactin is still poorly known. Previous studies have shown a correlation between sexual behaviour, prolactin release and prostate physiology. Thus, here we used the sexual behaviour of male rats as a model for studying this correlation. Hence, we developed experimental paradigms to determine the influence of prolactin on sexual behaviour and prostate organization of male rats. METHODS: In addition to sexual behaviour recordings, we developed the ELISA procedure to quantify the serum level of prolactin, and the hematoxilin-eosin technique for analysis of the histological organization of the prostate. Also, different experimental manipulations were carried out; they included pituitary grafts, and haloperidol and ovine prolactin treatments. Data were analyzed with a One way ANOVA followed by post hoc Dunnet test if required. RESULTS: Data showed that male prolactin has a basal level with two peaks at the light-dark-light transitions. Consecutive ejaculations increased serum prolactin after the first ejaculation, which reached the highest level after the second, and started to decrease after the third ejaculation. These normal levels of prolactin did not induce any change at the prostate tissue. However, treatments for constant elevations of serum prolactin decreased sexual potency and increased the weight of the gland, the alveoli area and the epithelial cell height. Treatments for transient elevation of serum prolactin did not affect the sexual behaviour of males, but triggered these significant effects mainly at the ventral prostate. CONCLUSION: The prostate is a sexual gland that responds to prolactin. Mating-induced prolactin release is required during sexual encounters to activate the epithelial cells in the gland. Here we saw a precise mechanism controlling the release of prolactin during ejaculations that avoid the detrimental effects produced by constant levels. However, we showed that minor elevations of prolactin which do not affect the sexual behaviour of males, produced significant changes at the prostate epithelium that could account for triggering the development of hyperplasia or cancer. Thus, it is suggested that minute elevations of serum prolactin in healthy subjects are at the etiology of prostate abnormal growth.

http://www.ncbi.nlm.nih.gov/pubmed/1670 ... PlusDrugs1

An abnormally high level of prolactin (hyperprolactinemia) is a condition characterized by elevated serum levels of the hormone prolactin in non-pregnant individuals. Hyperprolactinemia may cause progressive pattern hair loss due to an indirect effect on increasing free testosterone level.

http://www.baldingblog.com/2007/04/02/p ... hair-loss/

 

[CCS]

rippleeffect,

are you saying masterbation could help build muscle? Are you aware that many guys have more or less testosterone? If you are really this worried, you should take oral spironolactone like IBM, and continue masterbating. I assume you want your hair so you can get women. But if you have sex, I bet you will have 10x the effect of masterbation.

BTW, I just put some DHT gel (andractim) on my dick. I haven't used it in months, but I'm giving it another go. That should probably raise my serum levels 50%, but I know it is the DHT made in the follicles that I need to worry about, and my Dutas takes care of that.

 

[ripple-effect]

Yes, I am saying masturbation can help build muscle. If you read the link I gave to the bodybuilding site then you will see that the strategy they give is based off the study they show. Masturbate every 7 days b/c on the seventh day of abstinence there is a 100+% increase in testosterone, but then it drops from there (Strategy for building muscle I guess). MY answer to this problem is NOT to take oral spironolactone but to ABSTAIN from masturbation all together. You don't need to masturbate to live.

 

[docj077]

Unfortunately, you're still lacking the necessary research in humans. As I posted above, ejaculation does not raise the concentrations of androgens or their metabolites in humans. As I've stated quite a few times before, males have androgen binding protein to sequester any excess testicular androgens that are produced. The concentration of androgens in the testicles remains significantly elevated at all times and at a level that is many times the concentration found in serum. Not only is this true, but any excess androgen production leaking into the blood would be offset by circulating SHBG. If there is a rise in testosterone levels that overcomes both the ABP and SHBG systems, then GnRH production will be diminished as will LH, FSH, testosterone, etc to compensate.

This system is entirely individual and while lab tests may give you an idea of someone's free and bound hormone levels, it will give you no idea of their physiologic norm. There has never been a correlation between a particular androgen level and hyperandrogenism. Each male is different.

 

[CCS]

MY answer to this problem is ... to ABSTAIN from masturbation all together. You don't need to masturbate to live.

sex would probably do the same thing as masterbation. do you advise that we abstain from sex? What brings you happiness in life?

 

[docj077]

The other interesting research tidbit that people often forget to look at is that when you look at hormonal profiles and pretty much any study using hormones in rats, you're looking at a system that isn't even comparable to human physiology. Humans have both ABP and SHBG for the duration of their reproductive lives produced by both the testes and the liver. Rats, on the other hand, have ABP to sequester hormones in the testes, but only have SHBG production by the liver during fetal development. This means that they don't necessarily have the same amount of serum androgen binding capacity that humans do at the hormone-binding globulin level, so any results you get demonstrating an elevation in hormone levels is quite likely not a reproducible phenomenon in humans.

 

[ripple-effect]

You must not of read the study I posted right after the one you posted involving 28 male volunteers. The study you show describes what happens specifically before and after ejaculation. The study I show describes what happens a week after ejaculation, and in a way all of the studies shown agree in a way because the second study I displayed shows that there was no change in testosterone within 6 days of abstinence right after ejaculation. In the mice studies they show that the testosterone did not increase until the SECOND consecutive ejaculation. The study you displayed does not show a time frame or the amount of times the men ejaculated leading the reader to believe it was only once.

 

[ripple-effect]

sex would probably do the same thing as masterbation. do you advise that we abstain from sex? What brings you happiness in life?

If you need to masturbate to stay happy then you aren't truly happy.

 

[docj077]

You must not of read the study I posted right after the one you posted involving 28 male volunteers. The study you show describes what happens specifically before and after ejaculation. The study I show describes what happens a week after ejaculation, and in a way all of the studies shown agree in a way because the second study I displayed shows that there was no change in testosterone within 6 days of abstinence right after ejaculation. In the mice studies they show that the testosterone did not increase until the SECOND consecutive ejaculation. The study you displayed does not show a time frame or the amount of times the men ejaculated leading the reader to believe it was only once.

So, you must be aware that the longer the duration of abstinence the less viable sperm are in ejaculate. Prolonged abstinence in men is clearly associated with altered fertility and impaired spermatogenesis.

What you are advocating is complete abstinence. Not only is that foolish, but also relatively unhealthy. Self-discovery is a huge part of human sexuality and incredibly important for proper psychological and sexual development.

Also, what makes you think that the same phenomenon would occur in humans. I posted my objection earlier and you have yet to disprove physiological truth.



By the way, the "if you have to masturbate, you're unhappy" crap belongs in your weekly Bible study, Scientology meeting, etc; not here. Happiness is a relative term, which means its completely individualized.

 

[Cassin]

sex would probably do the same thing as masterbation. do you advise that we abstain from sex? What brings you happiness in life?

If you need to masturbate to stay happy then you aren't truly happy.

Nonsense.

Sex (of all kinds) is critical to happiness. There is NOTHING wrong with making yourself as happy as possible sexually. Sex is part of being human. There is nothing wrong with it.

 

[RAKBS]

The point of life is to have sex (and by extension, reproduce)...not to masturbate.

I really don't buy into the masturbation causes hair loss thing, though. Even if it did cause a marginal rise in androgen levels, hair loss treatments should be capable of taking care of that.

 

[squeegee]

Another masturbation forums lol ...I like to f***, to masturbate and I am 29 and still not bald! WTF! MASTURBATION release stress...make me happy and me having sex forever with my GF... unk: The pussy Punisher!

 

[Ian Curtis]

My right arm just keeps getting bigger and bigger! :woot:
lol

 

[JayB]

ripple-effect,
Do whatever it is your little heart wants to. Noone here is going to listen to you and refrain from sexual contact. Theres no difference between ejaculation from masturbation or sex, and no red blooded man is going to pass up sex with someone hes into.

So you can refrain all you want, i really couldnt give two shits if your A-Sexual. You sound like a miserable desperate fool who can't pull sex with a girl for the life of him, so you justify it by saying you'd end up losing hair due to it anyway. And since your miserable, you want others to be miserable and refrain from sex as well.

Not gonna happen my a-sexual, half-a-man friend.

 

[ripple-effect]

I wonder why JayB is so pissed? I wonder why he's trying to put words into my mouth by mentioning "sexual contact." Is this your way of trying to prevent yourself from looking like a total loser because you don't want to admit that all you do is masturbate and really can't get any in real life? You really have no way of proving that unless you upload a porno video of you with whomever and prove that it's you in there..lol(I really don't care). I don't know you and you don't know me, so to judge like that is pretty stupid.


I'm not miserable bro, because I'm not all about sex when it comes to chicks like yourself. It's not like I'm speaking as someone who's never been where you're at, and to tell you the truth...masturbating only brang me short term pleasure. It made me miserable in the end, so to say that I'm trying to make you guys miserable is just wrong. I'm also not telling people to refrain from completely refrain from sex for the rest of their lives. Sex is a natural thing....there is no denying that. You should just do it after you're married though.


As for Doctor, I appreciate your constructive criticism I suppose. I'm aware of that study you mention...and it's true. The sperm will eventually expire but the body has it's natural way of dealing with that. I'm not advocating absolute abstinence and this is explained in my response to JayB. The reason I haven't responded to your earlier objection is because you have not responded to the study I posted involving the 28 male volunteers. This was the primary study I meant to show...the rat study were just posted as side support. Also you shouldn't rearrange my statement about masturbation and happiness. If I had said it like that then you would've been right but since I didn't...you are not right and you know it too otherwise you would've quoted me word for word.

 

[cruiser]

I just want to know how they got the mice to jack-off :jackit: :dunno: