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miRNA microarray profiling in patients with androgenic alopecia and the effects of miR-133b on hair growth
Androgenetic alopecia (Androgenetic Alopecia), a common alopecia, is often accompanied by abnormal expression of multiple miRNAs. This study aims to investigate abnorma…
www.sciencedirect.com
What’s interesting is that there’s a point where dht upregulates miR-133b expression. And less than that seems to do the opposite. Which makes sense as even non balding men have dht, and in normal cases dht actually helps with hair. It’s just scalp hair that is affected at a certain point.
“The expression of miR-133b was abnormally high in Androgenetic Alopecia patients. DHT (10−5 mol/L) inhibited human HF growth and upregulated miR-133b expression, and DHT (10−7 mol/L) induced human HF growth and downregulated miR-133b expression. HDPC proliferation was inhibited, and the expression of β-catenin was downregulated in the miR-133b mimic-transfected group compared with the control group (P < 0.05). Wnt/β-catenin pathway activator treatment significantly promoted HDPC proliferation and upregulated the expression of β-catenin (P < 0.05).”
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