Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails. Mayo researchers now report that using the measles virus vector; they've trimmed that multi-vector process with four reprogramming factors down to a single "one cycle" vector process. They say the process is safe, stable, faster and usable for clinical translation. The findings appear in the journal Gene Therapy.
https://www.sciencedaily.com/releases/2019/02/190212120046.htm
Paper:
https://www.nature.com/articles/s41434-019-0058-7
https://www.sciencedaily.com/releases/2019/02/190212120046.htm
Paper:
https://www.nature.com/articles/s41434-019-0058-7