More evidence for topical finasteride

[cthulhu2.0]

This is the 9th or 10th study on topical finasteride that I have seen performed in 2014. Could we be seeing a topical version of finasteride in the near future?
Topical Formulations Containing Finasteride. Part I: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat.

Monti D[SUP]1[/SUP], Tampucci S, Burgalassi S, Chetoni P, Lenzi C, Pirone A, Mailland F.
Author information


Abstract

In hair follicle (Hf) cells, the type-2 5-α-reductase enzyme, implicated in androgenetic alopecia, is selectively inhibited by finasteride (FNS). Because an effective topical formulation to deliver FNS to Hf is currently unavailable, this investigation aimed at evaluating in vitro FNS skin permeation and retention through and into hairless rat and human abdominal skin. Four hydroxypropyl chitosan (HPCH)-based formulations (P-08-012, P-08-016, P-08-063, and P-08-064) and one anhydrous formulation without HPCH (P-10-008) were tested. The pharmacokinetics in plasma and skin after application of P-08-016 or P-10-008 on dorsal rat skin with single and repeated doses was investigated. P-08-016 performed the best in driving FNS to the reticular dermis without producing a high transdermal flux. Neither the in vivo single nor the repeated dose experiments produced plasma levels of FNS and no differences were found between formulations concerning skin retention. No increase in the amount of drug retained in the skin was obtained with the repeated dose experiment. In conclusion, the HPCH-based formulation P-08-016 might represent an alternative to systemic therapy for its ability to promote a cutaneous depot of FNS in the region of hair bulbs, minimizing systemic absorption even after repeated treatments. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.

 

[benjt]

Do you have a link for a direct efficacy comparison of oral vs topical finasteride?

 

[otis]

This is the 9th or 10th study on topical finasteride that I have seen performed in 2014. Could we be seeing a topical version of finasteride in the near future?
Topical Formulations Containing Finasteride. Part I: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat.

Monti D[SUP]1[/SUP], Tampucci S, Burgalassi S, Chetoni P, Lenzi C, Pirone A, Mailland F.
Author information


Abstract

In hair follicle (Hf) cells, the type-2 5-α-reductase enzyme, implicated in androgenetic alopecia, is selectively inhibited by finasteride (FNS). Because an effective topical formulation to deliver FNS to Hf is currently unavailable, this investigation aimed at evaluating in vitro FNS skin permeation and retention through and into hairless rat and human abdominal skin. Four hydroxypropyl chitosan (HPCH)-based formulations (P-08-012, P-08-016, P-08-063, and P-08-064) and one anhydrous formulation without HPCH (P-10-008) were tested. The pharmacokinetics in plasma and skin after application of P-08-016 or P-10-008 on dorsal rat skin with single and repeated doses was investigated. P-08-016 performed the best in driving FNS to the reticular dermis without producing a high transdermal flux. Neither the in vivo single nor the repeated dose experiments produced plasma levels of FNS and no differences were found between formulations concerning skin retention. No increase in the amount of drug retained in the skin was obtained with the repeated dose experiment. In conclusion, the HPCH-based formulation P-08-016 might represent an alternative to systemic therapy for its ability to promote a cutaneous depot of FNS in the region of hair bulbs, minimizing systemic absorption even after repeated treatments. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.

This can be bought at www.hairgrowthmd.com but I have never herd o anyone using it with results. Topical finasteride has been out there a while now.

 

[damien_p_watermelon]

Does topical finasteride work as an alternative to oral, or as a new weapon in the arsenal?

 

[cthulhu2.0]

Does topical finasteride work as an alternative to oral, or as a new weapon in the arsenal?

There was a study compared using both and the efficacy was similar. It shows that minoxidil is readily absorbed by the scalp and into tge bloodstream. The aim of these studies is to find a carrier that deposits the finasteride for a longer duration into the epidermis, not only increasing efficacy but reducing systematic absorption into the bloid stream. Like i said ive seen close to 10 studies on finasteride enclosed nanoparticles in thepast year, so researchers obviously are seeing something.

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These are all on pubmed by the way

 

[hellouser]

There was a study compared using both and the efficacy was similar. It shows that minoxidil is readily absorbed by the scalp and into tge bloodstream. The aim of these studies is to find a carrier that deposits the finasteride for a longer duration into the epidermis, not only increasing efficacy but reducing systematic absorption into the bloid stream. Like i said ive seen close to 10 studies on finasteride enclosed nanoparticles in thepast year, so researchers obviously are seeing something.

- - - Updated - - -

These are all on pubmed by the way

Sounds promising. What's the vehicle?

 

[cthulhu2.0]

[h=1]Lipid nanoparticles for topical and transdermal application for alopecia treatment: development, physicochemical characterization, and in vitro release and penetration studies.[/h]Gomes MJ1, Martins S2, Ferreira D3, Segundo MA1, Reis S1.
[h=3]Author information[/h]

[h=3]Abstract[/h]Alopecia is a dermatological disorder, commonly known as hair loss, which affects up to half of the Caucasian male population by middle age, and almost all (95%) Caucasian men by old age. Considering that alopecia affects so many people and that there is currently no scientifically proven treatment with few side effects, new drug-delivery systems able to improve alopecia therapy are urgently required. With this purpose in mind, the present study aimed to develop lipid nanoparticles (nanostructured lipid carriers) with the ability to incorporate and deliver anti-alopecia active compounds (minoxidil and finasteride) into the dermis and hair follicles. Lipid nanoparticles, prepared by ultrasonication method, showed mean particle sizes around 200 nm, which is sufficient for reaching the dermis and hair follicles, and zeta potential values around -30 mV, which indicates good physical stability. Over 28 days of storage, no significant variations in these parameters were observed, which indicates that all nanoformulations are stable in storage over that period. Cryo-scanning electron microscope measurements showed that all the lipid nanoparticles exhibited a spherical shape and a smooth surface regardless of their composition. Differential scanning calorimetry studies allowed the determination of phase transition temperatures and confirmed the recrystallization of the lipid nanoparticles (recrystallization index between 11% and 86%). A high loading efficiency was achieved for finasteride (between 70% and 90%), while less than 30% was achieved for minoxidil nanoparticles, over 28 days. Controlled release assays in physiological conditions demonstrated that nanoparticles loaded with minoxidil yielded a prolonged release, as desired. Penetration assays through pig ear skin demonstrated that nanoparticles loaded with minoxidil andfinasteride had low levels of penetration. These results suggest that the proposed novel formulation presents several good characteristics indicating their suitability for dermal delivery of anti-alopecia active compounds.


[h=4]KEYWORDS:[/h]

Lipid nanoparticles it looks like