(excerpt from supplements index, re: MSM)
Health Benefits
MSM appears to inhibit pain impulses that travel along nerve fibers, acting as an analgesic. This property, along with the compound's potential anti-inflammatory actions, are often cited in explaining its use for combating the symptoms of arthritis, fibromyalgia, carpal tunnel syndrome and allergies.
In addition, MSM may reduce muscle spasms, increase blood flow and possibly contribute to the maintenance and repair of cartilage. Studies in rats indicate that MSM may help to delay the growth of certain types of cancerous tumors.
Specifically, MSM may help to:
Relieve arthritis symptoms. Those who use MSM supplements contend that it not only helps treat osteoarthritis--the degenerative form of arthritis that wears down cartilage over time--but rheumatoid arthritis, lupus and other autoimmune-related conditions as well.
Numerous studies have shown that sulfur levels in arthritic joints are lower than in healthy joints. MSM may help by delivering needed sulfur to the afflicted areas. Once in the joints, exactly how MSM works remains unclear: It may exert an anti-inflammatory, analgesic effect similar to that of aspirin.
It may also help to maintain or repair cartilage, the gel-like substance that cushions joints and that is a key ingredient of connective tissue. In a preliminary, double-blind study of 16 patients with degenerative arthritis, the pateints who took 2,250 mg of MSM daily for six weeks reported an 82% reduction in pain on average. Only two of those takng the placebo reported decreased pain--about 20%.
Treat chronic back pain. Taken in conjunction with supplements such as SAMe and glucosamine sulfate, MSM may be useful for treating chronic back pain resulting from muscle strain, ligament sprain, or the early degenerative changes that can affect joints and discs in the back. Advanced disc disease does not appear to respond to MSM treatment, however.
Slow cancer development. Several rat studies done at Ohio State University and the Oregon Health Sciences University have shown that MSM significantly slows the development of mammary and colon tumors when the laboratory animals were given chemicals designed to cause cancer. In these studies, MSM did not prevent cancer, but it did delay it. In the breast cancer study, for instance, MSM stalled the appearance of tumors by an average of 100 days. (The equivalent of about 10 human years.) Much more research is needed to determine if MSM can truly slow the progress of cancer in humans.
Reduce allergy symptoms. MSM may block histamines, compounds that can irritate and inflame the membranes of the nose, eyes, and throat. Some people have found MSM more effective than antihistamines for allergies, without the side effects so common in standard prescription and over-the-counter drugs.
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For arthritis: Take 500 mg two or three times a day. Using MSM cream or gel in addition to the supplement may provide extra benefit. Rub the cream on the painful area four or five times a day for best results.
For back pain: Take 500 mg three times a day. Using MSM cream or gel in addition to the supplement may provide extra benefit. Rub the cream on the painful area four or five times a day for best results.
For allergy symptoms: Take 500 mg twice a day.
Be sure to check out our Dosage Recommendations Chart for MSM, which lists therapeutic dosages for specific ailments at a glance.
Guidelines for Use
Take MSM with or directly after meals to lessen the possibility of gastrointestinal upset.
If you find that MSM increases your energy level, avoid taking it too close to bedtime.
For most ailments, allow at least a month to see results.
General Interaction
If you are on a blood thinner (anticoagulant), such as aspirin or warfarin (Coumadin), consult with your doctor before taking MSM. It can occasionally have a blood-thinning effect.
Note: For information on interactions with specific generic drugs, see our WholeHealthMD Drug/Nutrient Interactions Chart.
Possible Side Effects
Because no rigorously controlled studies of MSM usage of any length have been done in humans, long-term effects are not presently known.
Some people develop minor gastrointestinal discomfort, such as cramping and increased stool frequency with MSM use.
In rare cases, a skin rash may appear. Stop using MSM if this or any other allergic reaction occurs.