Rogazzle
Established Member
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Silicon Dioxide (dust/crystals) are implicated in lung carcinogenesis when inhaled. The crystals are too small for the lung lining to remove, causing irritation and cancer similar to asbestos.
However In-vivo, Silicon Dioxide that's absorbed internally mostly gets excreted. But the stuff that remains will undoubtedly cause problems.
Silicon Dioxide Nanoparticles Exert Dissimilar Cytotoxic Effects on Mammalian Cell Types
SiO2 microparticles are toxic in animals in vivo and SiO2 nanoparticles are toxic in some mammalian cell types in vitro although studies using human cell types are scarce. Our goal is to systematically characterize the cytotoxic effects of SiO2 nanoparticles on various human cell types and elucidate the underlying mechanisms. In this study, we have compared the effects of the nanoparticles on human astrocytoma U-87 (astrocytes-like), human neuroblastoma SK-N-SH (neurons-like), and normal human fibroblasts. Results from MTT assay and cellular lactate dehydrogenase release suggest that treatment of the cell types with SiO2 nanoparticles (0.1-100 ug/ml) exerted dose-related, differential cytotoxic effects on the human cell types studied, the effect being least pronounced in fibroblasts. Observations of the treated cells using bright-field light microscopy were compatible with the results noted using MTT assay. We are investigating the cell signaling mechanism underlying cell death induced by SiO2 nanoparticles. Thus, our results indicate SiO2 nanoparticles exert differential cytotoxic effect on human cell types and may have implications in risk assessment of environmental and occupational exposure to these nanoparticles.
http://www.nsti.org/Nanotech2008/showab ... ?absno=490
Not scary enough? How about this?
http://www.ivanfraser.com/articles/health/sics.html
Any thoughts? Seriously, WTF are drug companies doing to us?
However In-vivo, Silicon Dioxide that's absorbed internally mostly gets excreted. But the stuff that remains will undoubtedly cause problems.
Silicon Dioxide Nanoparticles Exert Dissimilar Cytotoxic Effects on Mammalian Cell Types
SiO2 microparticles are toxic in animals in vivo and SiO2 nanoparticles are toxic in some mammalian cell types in vitro although studies using human cell types are scarce. Our goal is to systematically characterize the cytotoxic effects of SiO2 nanoparticles on various human cell types and elucidate the underlying mechanisms. In this study, we have compared the effects of the nanoparticles on human astrocytoma U-87 (astrocytes-like), human neuroblastoma SK-N-SH (neurons-like), and normal human fibroblasts. Results from MTT assay and cellular lactate dehydrogenase release suggest that treatment of the cell types with SiO2 nanoparticles (0.1-100 ug/ml) exerted dose-related, differential cytotoxic effects on the human cell types studied, the effect being least pronounced in fibroblasts. Observations of the treated cells using bright-field light microscopy were compatible with the results noted using MTT assay. We are investigating the cell signaling mechanism underlying cell death induced by SiO2 nanoparticles. Thus, our results indicate SiO2 nanoparticles exert differential cytotoxic effect on human cell types and may have implications in risk assessment of environmental and occupational exposure to these nanoparticles.
http://www.nsti.org/Nanotech2008/showab ... ?absno=490
Not scary enough? How about this?
http://www.ivanfraser.com/articles/health/sics.html
Any thoughts? Seriously, WTF are drug companies doing to us?