My thoughts on lowering prolactin with Selegiline

Harie

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Well, I've been taking 5mg EOD of Selegiline for 2 weeks now and I've got to say, I like it. I haven't noticed raging boners or anything, but it does seem to stave off ejaculation for a while longer than normal, and it makes me a bit hornier than I already was.

For those that don't know why I'm using Selegiline, I have been taking it to try and lower my prolactin levels among other things. I must admit that I have no idea if they are high since I didn't get a hormone test before starting it.

I'm going to take 5mg EOD for a few more weeks, then switch to 5mg/day to see what effects I feel, if any.


The info below is taken from http://www.selegiline.com

"Selegiline has immune-system-boosting and anti-neurodegenerative effects. Its use increases the level of tyrosine hydroxylase, growth hormone, cerebral nitric oxide and the production of key interleukins. Selegiline offers protection against DNA damage and oxidative stress by hydroxyl and peroxyl radical trapping; and against excitotoxic damage from glutamate. In addition, selegiline stimulates the release of superoxide dismutase (SOD). SOD is a key enzyme which helps to quench the production of damaging free-radicals. Potentially, selegiline may prevent or reverse iron-induced memory impairment. The deposition of excess iron in the brain is implicated several neurodegenerative diseases.

Selegiline protects the mitochondria via its effects on mitochondrial membrane permeability: it directly interacts with the pore-forming structures. Mitochondria are the energy powerhouses of the eukaryotic cell where oxygen respiration occurs. If the mitochondrial theory of aging is correct, then the root cause of aging is damage to mitochondrial DNA by free radical leakage from adjacent respiratory proteins. Alas selegiline itself is not an elixir of eternal youth. But its current "off-label" use by life-extensionists prefigures the longevity-enhancing mitochondrial medicine of decades to come.

Taken consistently at low dosage, selegiline tends to extend the life-expectancy of rats by some 20%; enhances drive, libido and endurance; and independently improves cognitive performance in Alzheimer's patients and in some healthy normals. Its protective role against age-related memory decline derives at least in part from its protection of hippocampal neurons in the aging brain. Aging drug-free rats have poorer spatial memories and fewer hippocampal neurons than their counterparts on selegiline. Selegiline is already used successfully to treat canine cognitive dysfunction syndrome (CDS) in dogs."
 

Keyser Söze

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Hi Harie, where are you purchasing this product from ? I've experimented with chasteberry a while back but it didn't do anything I just noticed increased shedding with it so I dropped it a few months ago, have you ever tried Cabergoline..
 

Harie

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Keyser Söze said:
have you ever tried Cabergoline..

If it weren't for this study http://www.foxnews.com/story/0,2933,241 ... /neurology I would have rather used Cabergoline. Study just came out in Jan 07. Shows link between Cabergoline & leaky heart valves in Parkinson's patients. Granted, the Parkinson's patients are older, and were taking 1mg/day (much more than anyone else would take), so maybe the risk to anyone else is not there. Regardless, I was worried, so I decided not to risk it.

As for Chasteberry, I tried that too for about 6 months and noticed nothing at all except that my wallet was $3.00 lighter. I know that Immortal Hair loves the stuff though, and a few others at regrowth.com like it too.
 

docj077

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So, you're taking a selective MAO inhibitor to increase dopamine in the brain so as to decrease prolactin and reduce side effects.

Interesting...
 

Harie

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docj077 said:
So, you're taking a selective MAO inhibitor to increase dopamine in the brain so as to decrease prolactin and reduce side effects.

Interesting...

Interesting as in, Harie you're an idiot? Or interesting as in, that may be a decent idea? :)
From the other reported benefits of Selegiline, it's long track record and the life extension people taking it, didn't seem like it would hurt anything.
 

docj077

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Harie said:
docj077 said:
So, you're taking a selective MAO inhibitor to increase dopamine in the brain so as to decrease prolactin and reduce side effects.

Interesting...

Interesting as in, Harie you're an idiot? Or interesting as in, that may be a decent idea? :)
From the other reported benefits of Selegiline, it's long track record and the life extension people taking it, didn't seem like it would hurt anything.

No, interesting as in you're using it for exactly the purpose that any given medical professional would use it for. Selegiline is a selecive monoamine oxidase B inhibitor. It inhibits the enzyme that would normally breakdown dopamine in the brain. The increase in dopamine prevents the release of prolactin.

It's efficient and scientific. I have no problem with what you're doing as long as a medical professional has some idea of what you're doing. Messing with dopamine in the brain can be ugly.
 

Harie

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Another interesting note to add. It seems that since I've been taking Selegiline, I've been in a better mood too. My wife and I have hardly fought at all in the last few weeks. It's pretty odd for us to go more than a few days without getting into a heated argument about something. I just generally seem to be in better spirits. Maybe it's the placebo effect for the better mood part...Either way, I'll take it.

I know that studies have shown that Selegiline can lessen depression, and I don't think I was depressed...All I know is that I feel good.
 

Harie

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I also quoted it above, but didn't really think about it till just now. "independently improves cognitive performance in Alzheimer's patients and in some healthy normals. Its protective role against age-related memory decline derives at least in part from its protection of hippocampal neurons in the aging brain."

This may be useful to offset the studies that suggest that inhibiting 5ar1 in the brain will result in Alzheimer's Disease later in life.
 

Harie

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Keyser Söze said:
Harie, when do you take your Selegiline dose morning or night with or without food ? Thanks

At night after my evening meal.
 

Harie

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Just google no prescription selegiline

Another note:

From reading today, it seems that Selegiline should not be used with bronchial dilaters. So, if you have asthma, you should probably not take Selegiline.

Which moves me to Cabaser (since I want to try Albuterol for non-asthma purposes) for my next go around.

I know I posted that it may cause heart valve degridation, but that was at 4mg/day dosages. So at 4mg/day (19x higher than I'm going to take) they had a 29% increased chance of getting heart valve degridation problems...And that's in Parkinson's patients. They didn't test anyone that wasn't a Parkinson's patient.
 

Keyser Söze

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This stuff is great ever since I added it my sex drive is thru the roof
I get spontaneous errections all day for no reason. As I'm typing this I'm sitting in my office with a partial stiffy. It has completely got rid of my finasteride
sides. I may need to ease up on the dose. As a bonus my wife hasn't been happier. :D
 
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