N-acetyl Cysteine May Help With Hair Loss (related To Pgd2)

Trichosan

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They found a potential initiator of inflammation via testosterone. It would be interesting to test the theory on nonbalding skin, increasing Pgd2 and see if it begins follicle atrophy. Does that make sense? Also, I wonder at what dose orally or topically NAC would be necessary to provide protection from test induced ROS. I've taken 600mg daily for years and it certainly never stopped my loss.
 
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itchymadscalp

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ffar1989

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Now is the question of dosage... I was also try to find info what is the best dosage for quercetin... no success in research :/
 
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arnoldd

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whatevr said:
High dose PGD2 inhibits testosterone synthesis in rat testicle...
But in human hair follicle it boosts the conversion of androstenedione into testosterone.

The two don't talk about the same thing, really.
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Rats have the same human endocrine sistem. Pgd2 study from costtarellis was done in rat or not ?
Now, the same pgd2 inihbit testo in testicles and ehance the conversion in hair follices ? Sounds strange
 
whatevr

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HairCook

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Trichosan said:
They found a potential initiator of inflammation via testosterone. It would be interesting to test the theory on nonbalding skin, increasing Pgd2 and see if it begins follicle atrophy. Does that make sense? Also, I wonder at what dose orally or topically NAC would be necessary to provide protection from test induced ROS. I've taken 600mg daily for years and it certainly never stopped my loss.
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Oral bioavailibility is sh*t.

NAC affects tnf-a, too. In a 600mg oral study it then affected only tgf-b.

Be careful about topical use. I was peeling like a snake cause I didnt care about ph value lol.
 
Georgie

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I’ve been taking 2g for maybe 3 weeks.
Haven’t noticed any decrease in shedding or anything. I’m taking a lot of other sh*t but I recently noticed some new growth at the hairline.
I’ve read on other non-alopecia hair forums that it’s like a miracle. I bought my powder from a naturopath who said without me even mentioning hairloss “this stuff is magic for your hormones and your hair. I take it”.
Idk. I’m a sceptical, angry motherfucker but it
Seems like a good add-on.
 
ZenHead

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What do you think would be more effective, topical or oral? I’m already on oral and topical seti.
 
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Alex Contee

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westonci said:
https://www.docdroid.net/oYVYFwE/101016-at-jjisp201701003.pdf
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The link is broken on my end.

I caution people to research a little more before blindly jumping on a new supplement. There is some promising research for Cysteine on diffuse hair loss:

However, there is nothing directly linking NAC directly as a possible treatment of alopecia. I really don't know how it would help unless you are losing hair from heavy metals and/or tons of free radicals. If you google "NAC hair loss forum" you will find people trying this stuff on long dead hair forums a decade ago. It does not seem like much came from it. I have no doubt it has the potential to give a boost but please do some research first.

itsjustsimon said:
Cmon... really?
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People should know about possible side effects before they start a supplement. You can easily throw your body out of whack and induce telogen effluvium. NAC is not naturally found in the body but is the acetylated form of cysteine. Unfortunately, it can acetylate many things indiscriminately (Unlike say Aspirin). Thus it is a potent anti-clotting agent. In combo with other anti-clotting agents your blood clotting time can be dangerously extended. Too many chelating agents and/or too many anti-oxidants can be harmful.
 
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Georgie

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Alex Contee said:
The link is broken on my end.

I caution people to research a little more before blindly jumping on a new supplement. There is some promising research for Cysteine on diffuse hair loss:

However, there is nothing directly linking NAC directly as a possible treatment of alopecia. I really don't know how it would help unless you are losing hair from heavy metals and/or tons of free radicals. If you google "NAC hair loss forum" you will find people trying this stuff on long dead hair forums a decade ago. It does not seem like much came from it. I have no doubt it has the potential to give a boost but please do some research first.


People should know about possible side effects before they start a supplement. You can easily throw your body out of whack and induce telogen effluvium. NAC is not naturally found in the body but is the acetylated form of cysteine. Unfortunately, it can acetylate many things indiscriminately (Unlike say Aspirin). Thus it is a potent anti-clotting agent. In combo with other anti-clotting agents your blood clotting time can be dangerously extended. Too many chelating agents and/or too many anti-oxidants can be harmful.
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Duely noted. I’ll drop my dose as I’m also on curcumin, coq10, milk thistle/Luceine/inositol, MSM, mainly because I’m on a fair few drugs that are harsh on the liver. Maybe drop back to a gram of NAC.
 
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Alex Contee

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Georgie said:
Duely noted. I’ll drop my dose as I’m also on curcumin, coq10, milk thistle/Luceine/inositol, MSM, mainly because I’m on a fair few drugs that are harsh on the liver. Maybe drop back to a gram of NAC.
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Unless you are specifically taking MSM for joint/muscle health MSM and NAC may be a little redundant. Both are a source of sulfur and cysteine. Both boost glutathione.
 
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