Serenoa Repens/Saw Palmetto/Permixon
This is very commonly known by patients and clinicians as it is widely available in most nutritional food stores. Serenoa repens berries grow naturally, with the extract claiming to inhibit DHT production, mainly claimed for use in prostate problems. There have been no extensive studies, but because of the stated implications of affecting DHT, men are anxious to try this OTC remedy to see whether it promotes hair growth on the scalp.
Studies that have been done have compared Permixon with finasteride in treatment of 1098 men with benign prostatic hypertrophy (BPH). Permixon improved symptoms of BPH but had no effect on androgen-dependent parameters such as DHT levels or 5a-R, indicating that its effects must be due to other yet undetermined pathways that do not involve DHT or 5a-R directly. Another study in 32 young men (aged 20 to 30 years) in a 1-week open trial looked at the effects of finasteride versus Permixon with regard to serum androgen levels; no effect on DHT levels were found in the Permixon-treated group, similar to the placebo group, whereas the finasteride group reduced DHT by 65%.*
*Stauch G, Perles P, Vergult G, et al. Comparison of finasteride (Proscar)) and Serenoa repens (Permixon) in the inhibition of 5-alpha-reductase in healthy male volunteers. Eur Urolo 1994;26:247-52.