Needling / Wounding / WNT / Lithium / Apple Poly -- Anyone?

[jakeb]

In my search to find non-androgen related treatments (I've developed a sensitivity to anti-androgens that is ridiculous), I've come across some posts elsewhere about hair growth via the WNT protien pathway.

The idea is based on U of Penn research (which has been licensed by Follica Inc to develop a commercial treatment).
WNT is a protein that signals stem-cells to regenerate skin (and hair follicles). You can activate WNT by wounding the skin (in a gentle way... usually needling or dermabrasion) and possibly applying a WNT encouraging topical (like Lithium or Apple Polyphenols).

Also, if you remember the hilariously named Dickkoph-3 (DKK)... DKK is an inhibitor of WNT. But apparently one can inhibit DKK using topical caffiene.

There seems to be some decent science on it and guys on other sites seem to be reporting success. I was wondering if there's anyone here giving it a try. I started this week.

 

[jakeb]

Since starting this about a week and a half ago, my shedding (hands covered with hair in the shower) has really drastically decreased.

I've probably jinxed myself by posting this. Tonight I'm probably going to shed like a Christmas tree in February.

 

[crespo]

thanks for the update. good luck with the routine and keep coming with the updates!

 

[jakeb]

Re: Needling / Wounding / WNT / Copper peptides -- Anyone?

Another week and a half, shedding / itching / inflammation still non existant. Never did add the lithium to the mix... wasn't really sure on how much to add and things seem to be going well as-is.

At this point I think I'll just have to wait a few months and see if it was just a seasonal coincidence that my shed ended or if something is really up here.

 

[cmudave]

very interesting, thanks for keeping us updated, please continue to do so...im anxious to see the results

 

[powersam]

In my search to find non-androgen related treatments (I've developed a sensitivity to anti-androgens that is ridiculous), I've come across some posts elsewhere about hair growth via the WNT protien pathway.

The idea is based on U of Penn research (which has been licensed by Follica Inc to develop a commercial treatment).
WNT is a protein that signals stem-cells to regenerate skin (and hair follicles). You can activate WNT by wounding the skin (in a gentle way... usually needling or dermabrasion) and possibly applying a WNT encouraging topical (like Lithium or Apple Polyphenols).

Also, if you remember the hilariously named Dickkoph-3 (DKK)... DKK is an inhibitor of WNT. But apparently one can inhibit DKK using topical caffiene.

There seems to be some decent science on it and guys on other sites seem to be reporting success. I was wondering if there's anyone here giving it a try. I started this week.

in your post you talk about the positive effect of WNT, and then about how DKK inhibits WNT. why would an inhibitor of WNT be a hair loss treatment?

 

[Follically Challenged]

Also, if you remember the hilariously named Dickkoph-3 (DKK)... DKK is an inhibitor of WNT. But apparently one can inhibit DKK using topical caffiene.

in your post you talk about the positive effect of WNT, and then about how DKK inhibits WNT. why would an inhibitor of WNT be a hair loss treatment?

 

[jakeb]

That's what I get for writing a run-on sentence... to be more clear: caffeine inhibits dkk. So, less dkk should mean more wnt.

 

[powersam]

my bad.

 

[hairsucks]

Hows the needling going Jakeb ?

 

[harold]

Does anyone have any references on caffeine inhibiting dickkopf?
hh