New Ar Antagonists Stronger Than Darolutamide Have Been Developed

[hemingway_the_mercenary]

UT-155 Shows promise and might be the greatest anti-androgen every created.

https://www.ncbi.nlm.nih.gov/pubmed/28978635


They are now finally looking at androgen receptor degradation. Not only do they bind to the receptro with a much higher affinity than Enzalutamide, but they have focused specificly on AR degredation for tumors resistant to even Enzalutamide. We are approaching the holy grail.

This class of drugs is called SARDs, selective androgen receptor degraders. And here's the best part, once of thse drugs is in trails for acne as a topical solution, the active component is Dimethylcurcumin. Now I doubt that its anywhere near as strong as UT-155 but it would be great to have some studeis on topical anti androgens.
https://en.wikipedia.org/wiki/Dimethylcurcumin

With these new drugs there is hope even for those with the most aggressive forms of androgenic alopeica

Its crazy to say but if it wasnt for prostate cancer we'd be left all alone to rot.

 

[furrydome]

Thanks for digging this up. From the wiki article on Dimethylcurcumin:

... appears to act as a selective degradation enhancer (SARD) of certain subpopulations of the AR, for instance those present in the prostate gland

This might suggest that a SARD could be developed to target receptors in the scalp. The safety and side effect profile of that could make it a great target for commercialization.

 

[el_duterino]

ASC-J9 is old new..it was hyped on these forums over 10 years ago and they were hints of plans for future trials for hair loss... but all got canceled due to its long serum life and side effects many years ago

Any drug that is planned for prostate cancer will never work for male pattern baldness as a long term maintenance valid treatment

CB is the future

 

[Armando Jose]

Any drug that is planned for prostate cancer will never work for male pattern baldness as a long term maintenance valid treatment

Finas was designed initially for BPH..... ?¿

 

[hemingway_the_mercenary]

ASC-J9 is old new..it was hyped on these forums over 10 years ago and they were hints of plans for future trials for hair loss... but all got canceled due to its long serum life and side effects many years ago

Any drug that is planned for prostate cancer will never work for male pattern baldness as a long term maintenance valid treatment

CB is the future

Yes but I’m taking about ut-155. It’s very new and shows to be the strongest anti androgens ever with degradational properties

What I’m saying that they are finally targeting SARDs. This is a huge step for male pattern baldness sufferers since I believe the development of theAR is why we go bald

male pattern baldness is triggered when the AR reaches the sensitivity point and begins to effect gene expression. That’s why some men go bald st 40 when clearly they have lower androgen levels at 40 than at 20. I believe it’s because that the AR continues to develop in men, and more exposure increases AR sensitivity. So if we can degrade the receptors we can shut down the male pattern baldness process not slow it down

I have absolutely zero hope for cb. You have a very mild form of hairloss and respond o Ru. Clearly there is no need for any of these drugs for you.

 

[alibaba92]

Yes but I’m taking about ut-155. It’s very new and shows to be the strongest anti androgens ever with degradational properties

What I’m saying that they are finally targeting SARDs. This is a huge step for male pattern baldness sufferers since I believe the development of theAR is why we go bald

male pattern baldness is triggered when the AR reaches the sensitivity point and begins to effect gene expression. That’s why some men go bald st 40 when clearly they have lower androgen levels at 40 than at 20. I believe it’s because that the AR continues to develop in men, and more exposure increases AR sensitivity. So if we can degrade the receptors we can shut down the male pattern baldness process not slow it down

I have absolutely zero hope for cb. You have a very mild form of hairloss and respond o Ru. Clearly there is no need for any of these drugs for you.

20+ year to see this thing in the market ?

 

[hemingway_the_mercenary]

20+ year to see this thing in the market ?

maybe 5-7 who knows. Its a drug that fights againts forms of drug resistent cancer so the FDA might make their process faster

does it matter tho, yore gonna need to get it in the black market, and would you even risk taking it

 

[abcdefg]

maybe 5-7 who knows. Its a drug that fights againts forms of drug resistent cancer so the FDA might make their process faster

does it matter tho, yore gonna need to get it in the black market, and would you even risk taking it

If its not approved for male pattern baldness there are a lot of hurdles that most men wont see as worth it for using this for male pattern baldness. No legit producer, ridiculously expensive, legality questions, and so on. Not to mention lacking evidence it even works for male pattern baldness, plus your talking a decade before its even out to buy once it approved for other conditions.
Just because it knocks out the AR does not mean its side free. it could have its own but currently unknown nasty side effects.
Not to mention still best case your talking maintenance. Nothing related to any AA no matter how powerful can reverse male pattern baldness it cant be done. Most men dont start any AA until they are in the middle of balding, and many many other things come into play after androgens which might be why some men cant reverse male pattern baldness they start too late.

 

[el_duterino]

To treat cancer of the prostate you need effective drugs that stay effective for a while in the body after reaching the blood stream

This is the exact opposite what we want to male pattern baldness

The fact that there isn't a single mention of hair loss as potential application in those studies should be a clear indication

Systemic powerful anti androgen have been developed since the mid 1970s and there haven't been reports any sort of miraculous regrowth of bald guys