New study on N-Acetyl-Cystein (Glutathione precursor)

[StayPositive]

Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

AbstractBackground. Androgenetic alopecia (Androgenetic Alopecia), the most common form of hair loss in men, involves the progressive loss of visible pigmented terminal hair

academic.oup.com

 

[OtyMac]

Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

AbstractBackground. Androgenetic alopecia (Androgenetic Alopecia), the most common form of hair loss in men, involves the progressive loss of visible pigmented terminal hair

academic.oup.com

I have been waiting for the day n-acetylcysteine- amide becomes available too.

Sci-Hub | N-Acetylcysteine amide: a derivative to fulfill the promises of N-Acetylcysteine. Free Radical Research, 47(5), 357–367 | 10.3109/10715762.2013.781595

“ NAC has so far not fulfi lled the impressive promises that theory and experimental research have put forward, thus it seems to share the destiny of other antioxidants ” [25]."

The failure of NAC to provide significant effect is presumably due to its low bioavailability (6 – 10%) and hydrophobicity. At physiological pH, the NAC acquires negative charge by losing a proton from carboxyl group.

The deprotonation hinders its passage across the biological membrane [26,27].

In a critical oxidative stress condition, either 600 mg of NAC or the bioavailable concentration of NAC may not be enough to replenish the GSH content. In addition, the long-term administration of NAC (600 mg) was found to be ineffective. Moreover, few studies demonstrated the pro-oxidant nature of NAC at higher concentration. These limitations, in part, explain the remarkable lack of success in wide variety of disorders.


Moreover, superior quality of NACA against NAC in membrane permeability has been well demonstrated using human red blood cells (RBCs) as a model system [31]. The study also proposed a mechanism of NACA in generating reduced GSH. Both NAC and NACA reduced intracellular oxidation induced by tert-butylhydroxyperoxide (BuOOH) in human RBCs to varied extent where NACA was found to be five times more potent than NAC. Treatment with NACA restored 91% of endogenous thiol in RBCs, while NAC reached only 15% suggesting greater membrane permeability of NACA.

{me: is this the reason for the 10% topical NAC creams in other diseases?}

N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma - PubMed

Mitochondrial dysfunction is becoming a pivotal target for neuroprotective strategies following contusion spinal cord injury (SCI) and the pharmacological compounds that maintain mitochondrial function confer neuroprotection and improve long-term hindlimb function after injury. In the current...

pubmed.ncbi.nlm.nih.gov

A couple of other studies on topical NAC used like 10% concentration for atopic dermatitis and some other skin conditions. I would be curious why they are using such high concentrations in other skin diseases and also would that be efficacious in Androgenetic Alopecia at those doses?

 

[jamesbooker1975]

this guy is on 9gm nac /day lol the hair

Rapamycin Treatment for Age Related Diseases (rapamycintherapy.com)

View attachment 171399

on a serious note, i'm also using high dose to avoid phlegm in throat when running

this guy is on 9gm nac /day lol the hair

Rapamycin Treatment for Age Related Diseases (rapamycintherapy.com)

View attachment 171399

on a serious note, i'm also using high dose to avoid phlegm in throat when running

"Early-onset Androgenetic" Do you understand the meaning on " EARLY "

 

[OtyMac]

this guy is on 9gm nac /day lol the hair

Rapamycin Treatment for Age Related Diseases (rapamycintherapy.com)

View attachment 171399

on a serious note, i'm also using high dose to avoid phlegm in throat when running

On the webpage you provided they also use glycine:

In March 2021, high dose supplementation with amino acids cysteine as NAC and glycine was revealed as an effective treatment for glutathione deficiency and mitochondrial dysfunction in older persons

Dose:
Glycine .1 grams/kilo
NAC .13 grams/kilo

How to take: Dose divided into 3-4 times a day to prevent GI distress from too much NAC.
Glycine: Available in 2.2 pound bag. Glycine has a sweet taste and will dissolve very well in hot liquids like coffee, tea, etc.


I'll listen to the videos because of other reasons but do you know is he on rapamycin too?

 

[OtyMac]

At high doses, NAC can act as a pro-oxidant and maybe this is why the doctor is almost totally bald?
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N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why

(2018). N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radical Research: Vol. 52, No. 7, pp. 751-762.

www.tandfonline.com

However, it should be pointed out that the pro-oxidant action of NAC is unlikely to occur in in vivo conditions because it was found to happen under certain reaction conditions, such as the presence of free transition metal ions, high NAC concentrations, and simplified matrices which do not occur in in vivo conditions.
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Forget about taking exogenous glutathione also:

Glutathione Metabolism and Its Implications for Health

Abstract. Glutathione (γ-glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight thiol, and GSH/glutathione disulfide is the major redox coup

academic.oup.com

The extreme concentration gradient across the plasma membrane makes the transport of extracellular GSH or GSSG into cells thermodynamically unfavorable. However, γ-Glu-(Cys)2 is readily taken up by extrahepatic cells for GSH synthesis. The kidney, lung, and intestine are major consumers of the liver-derived GSH (8). The interorgan metabolism of GSH functions to transport cysteine in a nontoxic form between tissues, and also helps to maintain intracellular GSH concentrations and redox state