New Topical finasteride Study (Full Text Available)

[Thor9]

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onlinelibrary.wiley.com

 

[fashy]

Is this the first study on topical finasteride use that concludes that it lowers systemic exposure compared to its oral counterpart?

 

[whymedamn]

I dont get it. How ..

 

[kiwi666]

Probably worth a try then. Did you give it a whirl

 

[scientist_0005]

in my next life i will become a reseaecher in hair loss science becsuse it allows you to have a noble income while in fact being the king of sh*t lords with an iq undetectable by modern evaluation. they did some great work there, applying 1/20th - 1/5th of a ml per day, surely enough to cover their testing cm^2 but when your area of baldness is more than a literal cm * cm then you have to apply 40-60 times the dosage they used. and they used 0.25 so quite a high concentration. i dont know where the funding for such studies is even coming from but i think it is shameful and if i could write the authors i sure would.

 

[scientist_0005]

oh wait.. the funding came from Almirall, a pharma company that released a topical finasteride solution in 2020. is it jzst by accident? of course! no hair loss researcher would sell their pathetic reputation for sh*t like this-unless of course, we are talking about hair loss reseaech after all, of course it is fucked

 

[scientist_0005]

basically they only tested it in the tatooed area 1cm^2 and applied 1/20th of a ml there so basically 0.11 mg of finasteride at the minimum and some men applied 4 times that amount to about 0.5mg of finasteride. but so highly concentrated that you cant even cover a hair line with it because it is only 0.2ml, a tenth of what any balding person would actually use. they were smart in using the bottle with the tiny tiny sprayer bit of course any half intelligent reader of the full study will pick up on their bullshit.

someone should definitely contact them and insult them

 

[scientist_0005]

It's actually a great study, they've proven the concept works in a large group of people, and that it reaches a steady state of less systemic DHT suppression than oral finasteride for no increase in adverse effects or loss of efficacy

I wish lower concentrations than 0.25% finasteride were tried in at least one arm, but that will come over time (and that's become the standard topical formula and so makes different studies more comparable)

yes they have proven that you can save 1cm^2 of your scalp and having just 35% dgt reduction instead of 55% which is not even that impressive. in my opinion the goal of this study was clearly misleading people because who sets up a study life that? that dose is ridiculous for actual therapeutic use. but sure, if they cut the finasteride concentration down to 0.2mg instead of 2.5 then it gets interesting and you can actually work with that. however the question then becomes whether surface area is able to absorb more and thus cause systemic sides more than applying a higher concentration in a very small area

 

[kidcurry96]

Even though spray was applied to one part, wont it reach the entire scalp?

 

[scientist_0005]

1cm^2 was just the study area where every subject sprayed at least once, and was used for before/after assessments

spray area seems to be a much wider diameter than that, there's a picture of the applicator in the study appendix

then they sprayed up to 3 more times in other, non-overlapping, balding areas (individualized as directed by doctor):
"Additional sprays (2-4), if recommended by the study doctor, were applied to cover the rest of the baldness area"
"Each actuation delivers 50 µL of solution, equivalent to 0.114 mg of finasteride"

i dont think thats ehat they did. have you read the full text?

 

[trialAcc]

oh wait.. the funding came from Almirall, a pharma company that released a topical finasteride solution in 2020. is it jzst by accident? of course! no hair loss researcher would sell their pathetic reputation for sh*t like this-unless of course, we are talking about hair loss reseaech after all, of course it is fucked

How stupid are you? What company that is pursuing selling a drug doesn't do the research to support that drug? That's how the global health care market works.

 

[kiwi666]

How stupid are you? What company that is pursuing selling a drug doesn't do the research to support that drug? That's how the global health care market works.

Just not how FDA works.

 

[kiwi666]

4. For non-diffuse thinners, you can limit yourself to spraying just the balding areas like this study and expect a good outcome and less serum DHT suppression. You could view the validation that you can target specific areas as a positive

Yeah I could just use it on my crown - so where’s the topical GB bîtchez?!?

 

[scientist_0005]

thinning in Norwood 6 feels amazing, can not use this at all

 

[MaestroTR]

the fact that we keep using sources on finasteride research feel pathetic

 

[trialAcc]

Just not how FDA works.

What?

 

[kiwi666]

FDA approval only shows that something is safe. Whether it’s “effective’ isn’t their problem.