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A pilot study evaluating the efficacy of topically applied niacin
derivatives for treatment of female pattern alopecia
Background
Female pattern alopecia is a common dermatologic condition that manifests
after puberty. The only approved drug treatment for this condition is 2% minoxidil for topical application.
Aims
This pilot study examined the effect of topical application of two niacin derivatives, octyl nicotinate and tetradecyl nicotinate, on hair fullness in female alopecia.
Patients/methods
Sixty female subjects with Ludwig types I–III female pattern hair loss
were evaluated in a double-blinded, placebo-controlled (40 active, 20 placebo) design using standardized 35-mm photographic analyses for assessment of efficacy after 6 months of application.
Results
The niacin derivatives demonstrated a statistically significant increase in hair
fullness (P =0.04 compared to the placebo).
Conclusion
Whereas evaluation of hair growth in women is challenging, this 6-month
pilot study demonstrated statistically significant increase in hair fullness on blinded 35-mm photographic analysis. Long-term topical application of nicotinic acid derivatives offers promise for providing benefit in female alopecia and warrants further study.
more: http://www.mentorcorp.com/pdfs-global/n ... mentof.pdf
derivatives for treatment of female pattern alopecia
Background
Female pattern alopecia is a common dermatologic condition that manifests
after puberty. The only approved drug treatment for this condition is 2% minoxidil for topical application.
Aims
This pilot study examined the effect of topical application of two niacin derivatives, octyl nicotinate and tetradecyl nicotinate, on hair fullness in female alopecia.
Patients/methods
Sixty female subjects with Ludwig types I–III female pattern hair loss
were evaluated in a double-blinded, placebo-controlled (40 active, 20 placebo) design using standardized 35-mm photographic analyses for assessment of efficacy after 6 months of application.
Results
The niacin derivatives demonstrated a statistically significant increase in hair
fullness (P =0.04 compared to the placebo).
Conclusion
Whereas evaluation of hair growth in women is challenging, this 6-month
pilot study demonstrated statistically significant increase in hair fullness on blinded 35-mm photographic analysis. Long-term topical application of nicotinic acid derivatives offers promise for providing benefit in female alopecia and warrants further study.
more: http://www.mentorcorp.com/pdfs-global/n ... mentof.pdf
