Dermatology 1998;196(4):474-7
Ketoconazole shampoo: effect of long-term use in androgenic alopecia.
Pierard-Franchimont C, De Doncker P, Cauwenbergh G, Pierard GE
Department of Dermatopathology, University of Liege, Belgium.
BACKGROUND: The pathogenesis of androgenic alopecia is not fully understood.
A microbial-driven inflammatory reaction abutting on the hair follicles
might participate in the hair status anomaly.
OBJECTIVE: The aim of our study was to determine if ketoconazole (KCZ) which
is active against the scalp microflora and shows some intrinsic
anti-inflammatory activity might improve alopecia.
METHOD: The effect of 2% KCZ shampoo was compared to that of an unmedicated
shampoo used in combination with or without 2% minoxidil therapy. RESULTS:
Hair density and size and proportion of anagen follicles were improved
almost similarly by both KCZ and minoxidil regimens. The sebum casual level
appeared to be decreased by KCZ.
CONCLUSION: Comparative data suggest that there may be a significant action
of KCZ upon the course of androgenic alopecia and that Malassezia spp. may
play a role in the inflammatory reaction. The clinical significance of the
results awaits further controlled study in a larger group of subjects.
Publication Types:
Clinical trial
Controlled clinical trial
PMID: 9669136, UI: 98333743