Nizoral vs Ciclopirox Olamine - Antiandrogenic action vs Anti-inflammatory action?

[razelscnhaps]

I started nizoral since 2 weeks (4 times) but I feel losing more hair than in previous weeks when I used Sebiprox (ciclopirox olamine).

In addition, Sebiprox had completely eliminated pain scalp and all the weird sensations -nizoral not, more loss and return of scalp pain.

As it is perhaps even more important to calm inflammation than having an extra anti-androgenic effect, I wonder if making "sessions" of Nizoral serves some purpose.
Because on the anti-inflammatory side, Sebiprox works much better for me.

So, is Nizoral must be used regularly to benefit some anti-andro effect?
And should I consider the anti-inflammatory action more important than the andogenetic one?

 

[Dench57]

Depends what kind of inflammation you have. Just male pattern baldness inflammation? Seb derm? Psoriasis?

 

[razelscnhaps]

Mainly pain scalp (very very dry) and weird burning sensations and very little seb derm.

 

[abovedagame]

How often do u use sebiprox?

 

[razelscnhaps]

I stopped using it to begin Nizoral, I used it every 3 days like nizoral.

 

[abovedagame]

My Doctor told me sebiprox is good for Seb derm. I'm guessing if it helped more than nizoral than your issue was the Seb derm?

 

[Dench57]

Mainly pain scalp (very very dry) and weird burning sensations and very little seb derm.

I have the pain/burning too but don't have seb derm or any skin condition.

 

[razelscnhaps]

I have read that ciclopirox olamine (Sebiprox) has also a beneficial effect in Androgenetic Alopecia but it's maybe minor compared to anti-androgenic action of Nizoral :

"Hypoxia causes NRF2 inhibition: Neogenic and ciclopirox"

"It also exhibits anti-inflammatory activity due to inhibition of the synthesis of prostaglandins and leukotrienes."

 

[razelscnhaps]

Hi, I just try Sebiprox again and it's very clear: my scalp is completely calmed down. No pain on my scalp anymore - I can get my hands on it without feeling anything - which was not the case with Nizoral.

I return to my original question, Sebiprox or Nizoral, perfect anti-inflammatory action (for me at least ...) or extra anti-androgenic effect.
Maybe using both alternately ? (nizoral and Sebiprox 1x/Week)