Novel shampoo reduces hair shedding by contracting the arrector pili muscle

[partysnacks]

I haven't seen this study posted here yet, but this looks like such an interesting approach to help reduce hair shedding. The compound is tyramine hydrochloride, but the study didn't contain any details about the formulation.

Novel shampoo reduces hair shedding by contracting the arrector pili muscle via the trace amine-associated receptor - PubMed

A shampoo formulated with a selective TAAR agonist was demonstrated to contract the arrector pili muscle and reduce hair shedding subsequent to washing.

pubmed.ncbi.nlm.nih.gov

Some more background: https://www.hairlosscure2020.com/the-arrector-pili-muscle-aka-the-goosebump-muscle/

 

[Selb]

I haven't seen this study posted here yet, but this looks like such an interesting approach to help reduce hair shedding. The compound is tyramine hydrochloride, but the study didn't contain any details about the formulation.

Novel shampoo reduces hair shedding by contracting the arrector pili muscle via the trace amine-associated receptor - PubMed

A shampoo formulated with a selective TAAR agonist was demonstrated to contract the arrector pili muscle and reduce hair shedding subsequent to washing.

pubmed.ncbi.nlm.nih.gov

Some more background: https://www.hairlosscure2020.com/the-arrector-pili-muscle-aka-the-goosebump-muscle/

I always did feel my hair was healthy when I got goosebumps on my scalp. Maybe this works by inducing it artificially.

Miniaturized Hairs Maintain Contact with the Arrector Pili Muscle in Alopecia Areata but not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth - PubMed

Contact between the APM and the bulge in AA may be required for reversal of hair follicle miniaturization. Maintenance of contact between miniaturized follicles in AA could explain the complete hair regrowth while loss of contact between the APM and the bulge in MPHL and FPHL may explain why the...

pubmed.ncbi.nlm.nih.gov

Interestingly enough it’s hypothesized that the connection between the APM and the follicle allows for hair regrowth after miniaturization and when that connection is broken it becomes irreversible. If that’s the case, would this shampoo or topical potentially fix that connection if broken?


Great article here about enhanced regeneration of hair follicles, which also correlates with more APMs, when Lef1 expression was induced (another point towards the WNT pathway).

https://elifesciences.org/articles/60066.pdf

 

[Armando Jose]

why they used the product only in women?



















'

 

[Selb]

It sounds like the shampoo only thickens hair temporarily by delaying shedding, maybe by a couple weeks at the most. Those hairs that come out in the shower are already doomed, and they're going to come out before long whether this works or not.

The interesting thing is what you suggested. Goosebumps have been shown to strengthen the APM connection, if this can make it contract then it should do the same thing, and could have a longer term effect.

I definitely think it can strengthen that connection. But the question is if the connection’s been damaged does it regenerate the APM and follicle connection? Or at least accelerate its regeneration? I’d like to think it can.

I’m going to look into the topical and see if it’s cheap

 

[Jakejr]

Trace amines are biologically active amines occurring in the body in trace amounts.

Some examples of trace amines include tyramine, beta phenylethylamine, tryptamine and octopamine.
[TAAR agonist is octopamine or tyramine,]

 

[partysnacks]

Did some more research on this

From the article:

Additionally, the TAAR agonist shampoo showed similar efficacy to the synephrine hydrochloride solution previously tested in reducing shedding during brushing

Apparently, there was a previous study done using synephrine hydrochloride that had similar results:

Styling without shedding: Novel topical formula reduces hair shedding by contracting the arrector pili muscle

Styling without shedding: Novel topical formula reduces hair shedding by contracting the arrector pili muscle - PubMed

Approximately 40% of women experience excessive hair shedding during styling (e.g., hair brushing). Previously, we demonstrated that topically applied phenylephrine, a potent α₁ adrenergic receptor agonist, can be used to contract the arrector pili muscle of the follicular unit; thus...

pubmed.ncbi.nlm.nih.gov

And there's currently a phase I study going on right now for AB-102, which was the topical used in that study: https://appliedbiology.com/AppliedBiologyPipeline.html

I also learned bitter orange contains synephrine, so for us maybe its beneficial to experiment adding bitter orange EO to topicals/shampoos?
As for the % concentration:

During the study, subjects applied 0.5 mL of a 10% phenylephrine solution to an 8x10 cm target area. The size of the target area was chosen to insure that the total dosage stayed below our calculated safety margin. Phenylephrine, a classic selective a1-AR agonist, was chosen as the investigational drug because of its long and established safety profile. While demonstrating efficacy, phenylephrine has several potential drawbacks if applied to the entire scalp, including accidental ocular exposure resulting in prolonged pupil dilation and the possibility of dose dependent cardiovascular adverse events.

To circumvent the limitations of phenylephrine, we developed a novel formulation using synephrine. Synephrine has been studied extensively in its oral form and has not been shown to induce significant cardiac or hemodynamic changes (Stohs, Preuss, & Shara, 2011). Synephrine is an isomer of phenylephrine, different only in the positionof the phenolic hydroxyl group; phenylephrine has a meta-hydroxyl, while synephrine has a para-hydroxyl. Synephrine is a weak a1-AR agonist, exhibiting a potency approximately 150-fold less than that of phenylephrine (Brown et al., 1988). As such, a higher concentration was needed to observe the same a1-AR activation on the scalp. We hypothesized that this would be advantageous for two reasons: First, the higher concentration of the active would facilitate penetration through the stratum corneum (Benson, 2005). Second, owing to the low a1-AR binding affinity (Hibino, Yuzurihara, Kase, & Takeda, 2009;Ma, Bavadekar, Schaneberg, Khan, & Feller, 2010), synephrine would not likely cause systemic effects once diluted outside of the local application site.

So, synephrine was used at over 10% concentration, but who knows what exactly. I also don't know how much synephrine is in BO EO and a high concentration might cause side effects too, especially since there are other compounds that could be detrimental.

 

[Timii]

So do I get this right? If the connection between the APM and the follicle is strenghtened miniaturized haris have a better chance at regrowing?

 

[Selb]

Did some more research on this

From the article:

Apparently, there was a previous study done using synephrine hydrochloride that had similar results:

Styling without shedding: Novel topical formula reduces hair shedding by contracting the arrector pili muscle

Styling without shedding: Novel topical formula reduces hair shedding by contracting the arrector pili muscle - PubMed

Approximately 40% of women experience excessive hair shedding during styling (e.g., hair brushing). Previously, we demonstrated that topically applied phenylephrine, a potent α₁ adrenergic receptor agonist, can be used to contract the arrector pili muscle of the follicular unit; thus...

pubmed.ncbi.nlm.nih.gov

And there's currently a phase I study going on right now for AB-102, which was the topical used in that study: https://appliedbiology.com/AppliedBiologyPipeline.html

I also learned bitter orange contains synephrine, so for us maybe its beneficial to experiment adding bitter orange EO to topicals/shampoos?
As for the % concentration:

So, synephrine was used at over 10% concentration, but who knows what exactly. I also don't know how much synephrine is in BO EO and a high concentration might cause side effects too, especially since there are other compounds that could be detrimental.

Disappointing that they don’t include the concentration for the topical shampoo. The good news is that I found a supplement containing 10% synephrine every capsule:

https://www.amazon.com/dp/B0060SZOY8/ref=cm_sw_r_cp_awdb_imm_t1_xMY-Fb5EXW5T8

I think in terms of dosage, that’s around 10 mg of synephrine and a safe amount is below 100mg so that should be fine.

 

[Armando Jose]

Probably this product make exogen phase hair longer

 

[Selb]

Probably this product make exogen phase hair longer

I’m less interested in the artificial decrease in shedding. We should focus on the APM connection and its repair.

I spent a bit of time researching the APM and ways to induce its regeneration, or at least reattachment. Found a few things but what stands out is merkel cells. They are cells that may serve as “attractors” between the APM and the follicles.

https://scholar.google.com/scholar?...i+muscle&oq=arrec#d=gs_qabs&u=#p=ez0uimJeZe0J

Guess what produces more merkel cells? Skin injury. Microneedling in other words may contribute to the regeneration of the connection between the APM and the follicles. However it’s not perfect for some reason

 

[Armando Jose]

I’m less interested in the artificial decrease in shedding. We should focus on the APM connection and its repair.

It is OK, but what happen in hair trasplants?
APM and SG are part of Pilosebaceous Unit, in hair trasplant only SG is intact and APM need to be conected again.

 

[Selb]

It is OK, but what happen in hair trasplants?
APM and SG are part of Pilosebaceous Unit, in hair trasplant only SG is intact and APM need to be conected again.

I’m not too sure about that. A hair transplant should include the entire FU, which includes both the APM and SG

 

[Armando Jose]

Good question,
The difference is that the SG will be operative from the first moment of the transplant, while the AMP will need time to anchor itself in a stable connective tissue that helps it perform its function.