o.5 to 2.5

[antonio666]

I am seriously thinking about upping my dosage from 0.5 to 2.5 avodart.

i have just been readingf a book about the pacific islanders and it is a fact that there is a tribe that have been studied and it was found that they have 0 DHT IN THERE BODIES AND GUESS WHAT NOT 1 OF THESE PEOPLE HAVE EVER GONE BALD AT ALL,
wHAT I AM SAYING IS WOULD 2.5 TOTALLY VANISH DHT FROM MY BODY OR WOULD I NEED MORE

 

[antonio666]

might even up tp 10 times the recomende dose?

 

[blaze]

2.5mg per day will completely snuff out type 2 5AR which is produced inside the hair follicle.

There would be virtually 0 DHT left when taking that much. You definitely notice a difference when upping your dosage from 0.5mg to 2.5mg per day. The best results were from 2.5mg.

 

[antonio666]

i know jayman swears by avodart,jayman do you think this will help by going to 2.5 .The way i am going to do it is 1 cap GSK ,4 dr reddys
it is cheaper this way,i will be taking the gsk just in case the dr reddys are fake

 

[CCS]

you are going to have a VERY long half life at those higher doses. In 6 month, you could go on a trip around the world, and your blood levels of dutasteride would not fall enough for you to lose any hair.

But if you get side effects, watch out. They will not go away any time soon.

 

[hair today gone tomorrow]

you are going to have a VERY long half life at those higher doses. In 6 month, you could go on a trip around the world, and your blood levels of dutasteride would not fall enough for you to lose any hair.

But if you get side effects, watch out. They will not go away any time soon.

CCS, what are you talking about?!?...the half-life is has no relation to the dosage...they are INDEPENDENT from each other.

finasteride's half life is 6-8 hrs regardless if you take 1mg or 10mg
dutasteride's half life is 4-6 weeks regardless if you take .5mg or 2.5mg

 

[Guest]

i know jayman swears by avodart,jayman do you think this will help by going to 2.5 .The way i am going to do it is 1 cap GSK ,4 dr reddys
it is cheaper this way,i will be taking the gsk just in case the dr reddys are fake

sounds good. i mean thats still like $2000-2500 a year isn't it? If you figure $360 a year per generic capsule from inhouse, that's $1440, plus figure $1000 a year for taking a GSK Avodart each a day. If you're spending that kind of money, I'd just suggest saving up for 4 years and getting a transplant.

 

[docj077]

you are going to have a VERY long half life at those higher doses. In 6 month, you could go on a trip around the world, and your blood levels of dutasteride would not fall enough for you to lose any hair.

But if you get side effects, watch out. They will not go away any time soon.

CCS, what are you talking about?!?...the half-life is has no relation to the dosage...they are INDEPENDENT from each other.

finasteride's half life is 6-8 hrs regardless if you take 1mg or 10mg
dutasteride's half life is 4-6 weeks regardless if you take .5mg or 2.5mg

There is some relation, but it the quality of the relationship is really determined by whether or not dutasteride demonstrates first or zero order kinetics when it is metabolized. The half life won't change, but a higher dose will lead to dutasteride being in your system longer either way.

 

[Bryan]

CCS, what are you talking about?!?...the half-life is has no relation to the dosage...they are INDEPENDENT from each other.

finasteride's half life is 6-8 hrs regardless if you take 1mg or 10mg
dutasteride's half life is 4-6 weeks regardless if you take .5mg or 2.5mg

Dutasteride's half-life IS influenced by the blood level of the drug, and I've only been talking about that for years and years on these hairloss sites!

dutasteride has non-linear elimination characteristics. It's eliminated more rapidly at lower levels (relatively speaking) than it is at higher levels. I've mentioned that a whole bunch of times!! It's the reason why I've always been a little nervous when people start talking about reducing the effective dose by taking an Avodart capsule only once every few days (like once every 5 days to obtain an effective dose of 0.1 mg/day, for example). Taking it that way _will_ shorten the half-life, and _may_ cause problems with fluctuating levels of the drug in the bloodstream.

 

[hair today gone tomorrow]

CCS, what are you talking about?!?...the half-life is has no relation to the dosage...they are INDEPENDENT from each other.

finasteride's half life is 6-8 hrs regardless if you take 1mg or 10mg
dutasteride's half life is 4-6 weeks regardless if you take .5mg or 2.5mg

Dutasteride's half-life IS influenced by the blood level of the drug, and I've only been talking about that for years and years on these hairloss sites!

dutasteride has non-linear elimination characteristics. It's eliminated more rapidly at lower levels (relatively speaking) than it is at higher levels. I've mentioned that a whole bunch of times!! It's the reason why I've always been a little nervous when people start talking about reducing the effective dose by taking an Avodart capsule only once every few days (like once every 5 days to obtain an effective dose of 0.1 mg/day, for example). Taking it that way _will_ shorten the half-life, and _may_ cause problems with fluctuating levels of the drug in the bloodstream.

So, what do you recommend as the smallest effective dose? once every other day? or once every 2 days?

 

[IBM]

If dutasteride wasnt so expensive lots of people would take 2.5mg per day.

 

[Old Baldy]

Can't speak for Bryan but M-W-F should be all you need unless you're an aggressive balder IMHO.

That dosage might reduce Bryan's concern?

Bryan, what do you think about a M-W-F dutasteride. regimen? It appears it might be pretty much superior to 1mg of finasteride. daily, etc.?

I ask this mainly for younger guys starting out on treatments. Why waste their time on daily finasteride. if the above dutasteride. regimen is superior? (Plus, with my topical usage, I'm probably getting that much, or close to it, systemically[sp?]. Well, maybe my regimen would be more akin to twice a week oral dosage.)

Thanks for any opinion(s).

Btw Doctor, from all I've read, Bryan is right. dutasteride., at lower doses, gets eliminated faster than regular, daily doses. I have no idea why but that seems to be the case from all I've read.

I mean, even taking, one-half gelcap daily, (if you could somehow do that), the dutasteride. would get eliminated more quickly from the body than one full gelcap daily. (Bryan, correct me if I'm wrong on that one but that's the impression I have from reading up on dutasteride.?)

For some reason, completely unknown to me, the more dutasteride. you have in your bloodstream, the slower it gets eliminated, (i.e., even considering the dosing, ratio differences).

 

[Bryan]

So, what do you recommend as the smallest effective dose? once every other day? or once every 2 days?

Once every other day OR once every 2 days??? Aren't those the same thing??

But seriously, I would personally probably consider 2 Avodart capsules per week to be the minimal effective dose, which amounts to the equivalent of about 0.143 mg/day (a bit of an extra safety-margin in there above the accepted 0.1 mg/day dose). Obviously, you would want to take the two capsules evenly spread-out during the week.

BTW, lest you think I was making that up about the significantly declining half-life of dutasteride at lower serum levels, here's a section from the study "A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5a-Reductase Inhibitors GI198745 and Finasteride", Gisleskog et al, Clin Pharmacol Ther 1998;64: 636-47, which is also the source of all those nifty finasteride/dutasteride charts and graphs I've posted over the years:

RESULTS
Pharmacokinetics. In this study, the pharmacokinetics of GI198745 have been described with a 2-compartment model with 2 parallel elimination pathways -- a linear and a nonlinear pathway. At high concentrations the linear pathway dominates as the route of elimination, giving....a terminal half-life of up to 5 weeks. As concentrations declined toward the concentration at which the saturable elimination pathway operates at half maximal rate (Km) (0.96 ng/mL), the proportion eliminated through the relatively rapid saturable elimination pathway increased, and the half-life decreased to about 3 days. This marked decrease in half-life was a consequence of the relatively high clearance of the saturable pathway at low concentrations.

The only thing I need to add here is that the concentration they specify where the hal-life drops to about three days (0.96 ng/mL) looks to me (from staring at the other charts they provide in this study) like that should be pretty darned close to the concentration you get when you take 0.1 mg/day of dutasteride! Maybe just a little below that level of intake. So keep in mind that when you start taking only 1 or 2 Avodart capsules per week, the half-life is going to drop very significantly.

 

[Bryan]

Bryan, what do you think about a M-W-F dutasteride. regimen? It appears it might be pretty much superior to 1mg of finasteride. daily, etc.?

Sure. There's no doubt that it would be superior to 1 mg/day of finasteride.

I mean, even taking, one-half gelcap daily, (if you could somehow do that), the dutasteride. would get eliminated more quickly from the body than one full gelcap daily. (Bryan, correct me if I'm wrong on that one but that's the impression I have from reading up on dutasteride.?)

For some reason, completely unknown to me, the more dutasteride. you have in your bloodstream, the slower it gets eliminated, (i.e., even considering the dosing, ratio differences).

Hopefully, the section I quoted in my post above will give you a somewhat better overview of what happens with that. It's not that the absolute quantity of dutasteride that gets eliminated per unit of time gets lower as the amount in the bloodstream increases, it's that the relative amount that gets eliminated (as a proportion of the total quantity in the bloodstream) gets lower.

I gaurantee you that if you start taking the tiniest little dose of dutasteride and then gradually increase that to VAST doses of the drug, you will continue to eliminate larger and larger amounts of the drug per hour (or per day, or whatever). It's just that the increasing elimination of the drug won't quite keep pace with the amount that you're swallowing each day. It will continue to build up slowly, as long as you keep increasing your dose.

 

[Timi]

dutasteride

Bryan

dutasteride have made my Hairs very thinly arround the Head
all Hairs look ill
Front Hairs very thinned out


Other says Hair looks good

I do not understand that


when i take dutasteride my Scalp itches strongly

Higher Testosteron more free DHT in the scalp???
ore Upregulation?
ore wrong Genetics ??????????

Timi (15Month dutasteride)

 

[hair today gone tomorrow]

Sure. There's no doubt that it would be superior to 1 mg/day of finasteride.

you seem to say that with such certainty. Do you have any theory one why some people are claiming that dutasteride damaged their hair? fake drugs maybe?

 

[Old Baldy]

Thanks for the info. Bryan. I don't remember reading the 3 day elimination results for small dosing. I understand how the elimination of dutasteride. occurs now.

Thanks again!

So, if a guy took dutasteride. M-W-F, he might experience a half-life of roughly 1 to 2 weeks? (That dosage results in 0.214 mg per day.)

 

[otis]

That was the dosage where the had the best results