Optimal Finasteride Dosage is 50 mg/daily for Hair Growth

[Carlos Marcello]

Hi guys..

Optimal finasteride dosage is not 1 mg or 5 mg. Optimal finasteride dosage is 50 mg/daily for hair growth and preventing further hair loss..

Because 50 mg finasteride/daily therapy can reduce intrafollicular DHT by %90-95...

But 1 or 5 mg finasteride/daily can only reduce intrafollicular DHT by %25..

%25 intrafollicular DHT reduction is not enough for a lot of men..With this small reduction is not enough for hair growth and preventin further hair loss for lifelong.

http://img2.timg.co.il/forums/1_125030674.pdf

http://www.ncbi.nlm.nih.gov/pubmed/16834758

 

[isishearmyplea]

ummmmm

 

[zzzzz]

or instead of taking half a pound of pills daily you could just take dutasteride

 

[smyth01]

Carlos, stop making these stupid threads/posts.

 

[Carlos Marcello]

Carlos, stop making these stupid threads/posts.

Why do you think my threads and posts are stupid ?

Do you know what means ''intrafollicular DHT'' ?

Did you read these studies ??

http://img2.timg.co.il/forums/1_125030674.pdf

http://www.ncbi.nlm.nih.gov/pubmed/16834758

English is not my native language..But I'm trying to explaing something here..You should respect..

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or instead of taking half a pound of pills daily you could just take dutasteride

Finasteride with standart dosage decreases intrafollicular DHT by %25..

But I don't know dutasteride's effect on intrafollicular DHT ??

Maybe finasteride plus dutasteride therapy can lower intrafollicular DHT much more than alone therapy..

 

[Spanishlad]

Carlos, one minute you're saying no one should take finasteride at all the next minute you are suggesting we take 50mg. Is there a point to all this??

After lengthy clinical studies and careful consideration of effectiveness vs sides 1mg was shown to be the most suitable dose.. what you are sharing here is hardly ground breaking news

 

[Carlos Marcello]

Carlos, one minute you're saying no one should take finasteride at all the next minute you are suggesting we take 50mg. Is there a point to all this??

After lengthy clinical studies and careful consideration of effectiveness vs sides 1mg was shown to be the most suitable dose.. what you are sharing here is hardly ground breaking news

But I'm talking theoretically. I don't think use finasteride again.

But for hair growth its best dosage is 50 mg/day for intrafollicular DHT.

1-5 mg finasteride can only lower intrafollicular DHT by %25 and this small decrease is not enough for hair growth for a lot of men.

50 mg finasteride/daily has little side effects than 0,5 mg dutasteride. Side effects are similar. You can be sure that.

And I am sure..Someone who can use finasteride 50 mg/daily get results as good as hair transplantation.

Most important thing is intrafollicular DHT reduction for hair loss therapy and new hair growth.

(( Note : Please read this study's full version ıf you can find it.

http://www.ncbi.nlm.nih.gov/pubmed/16834758 ))

 

[DontWant2BeBald]

Yea brb spending a thousand dollars for a month of finasteride

 

[zzzzz]

a standard dose of .5mg dutasteride decreases intrafollicular DHT by a little over 50% if I remember correctly. If you take 2.5mg dutasteride, it decreases it by I think 75 or 80%?

also, I am pretty sure the DHT count we are talking about includes type I DHT, which isn't relevant to hairloss and in larger quantities in the scalp then it the bloodstream relative to type II DHT. So finasteride reduces DHT in the scalp by 25% but that is overall, the amount of type II specifically is much greater. Could you double check this to see if they mention specifically type II counts or is is just overall?

 

[xRedStaRx]

OP is copying what I've said before that 50mg/day reduced intrafollicular DHT similar to the prostate which is around 90%.

But what's your point? You don't need that much inhibition for it to 'work'.

 

[Carlos Marcello]

a standard dose of .5mg dutasteride decreases intrafollicular DHT by a little over 50% if I remember correctly. If you take 2.5mg dutasteride, it decreases it by I think 75 or 80%?

also, I am pretty sure the DHT count we are talking about includes type I DHT, which isn't relevant to hairloss and in larger quantities in the scalp then it the bloodstream relative to type II DHT. So finasteride reduces DHT in the scalp by 25% but that is overall, the amount of type II specifically is much greater. Could you double check this to see if they mention specifically type II counts or is is just overall?

But scalp DHT is different then intrafollicular DHT..İntrafollicular DHT is the most important problem for hair growth and further hair loss preventing.

Look at this paragraph from Deborah A. Finn's ''A New Look at the 5á-Reductase Inhibitor Finasteride'' study..

Another point to consider with regard to the relative efficacy of a specific finasteride
dose and resultant concentration in plasma and tissue is that the IC50 for finasteride in
prostate and scalp homogenates was reported to be 5.9 and 310 nM, respectively (98).
With this in mind, it was estimated that a concentration of 94 nM finasteride would inhibit
prostate homogenate 5á-reductase by 85%, but would inhibit scalp homogenate 5á-reductase
by 25% (66). Results from clinical studies that measured DHT reduction in prostatic
tissue (92) and scalp skin (28) are consistent with these estimates. By extrapolation, in
order to achieve a level of inhibition in scalp that was comparable to that in the prostate,
the concentration of finasteride in plasma would have to be 1 ìM (66), which would be
obtained following a 50 mg dose of finasteride (100).

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OP is copying what I've said before that 50mg/day reduced intrafollicular DHT similar to the prostate which is around 90%.

But what's your point? You don't need that much inhibition for it to 'work'.

Okay. Thank you. I heard the first time this information from you. And I made research and I learned different informations..

For some people %25 intrafollicular DHT reduction may be enough. But %25 reduction in intrafollicular DHT levels not enoguh for people who have agressive hair loss prognosis like me..

I see a lot of people who use finasteride with no benefits and start to use very strong antiandrogens like cyproterone acetate get great results as good as hair transplant.

Because cyproterone acetate blocks intrafollicular 5 alpha reductase and free testosterone leves very very strongly..

 

[xRedStaRx]

Okay. Thank you. I heard the first time this information from you. And I made research and I learned different informations..

For some people %25 intrafollicular DHT reduction may be enough. But %25 reduction in intrafollicular DHT levels not enoguh for people who have agressive hair loss prognosis like me..

I see a lot of people who use finasteride with no benefits and start to use very strong antiandrogens like cyproterone acetate get great results as good as hair transplant.

Because cyproterone acetate blocks intrafollicular 5 alpha reductase and free testosterone leves very very strongly..

Not 'a lot'. Finasteride had a non-responsive rate of around 10%, against Dutasteride's 0.6%.

But even then, the 'non-responsive rate' is measured as being below baseline. It still slows down the hair loss progression significantly. It's safe to say that if 1mg/day of finasteride does not work for you after 12 month, then Dutasteride remains a second option. Minoxidil is better at hair growth than both of them. So any stack with minoxidil should improve your results greatly at best, and nullify the non-responsive rate of finasteride at worst.

 

[zzzzz]

Not 'a lot'. Finasteride had a non-responsive rate of around 10%, against Dutasteride's 0.6%.

But even then, the 'non-responsive rate' is measured as being below baseline. It still slows down the hair loss progression significantly. It's safe to say that if 1mg/day of finasteride does not work for you after 12 month, then Dutasteride remains a second option. Minoxidil is better at hair growth than both of them. So any stack with minoxidil should improve your results greatly at best, and nullify the non-responsive rate of finasteride at worst.

.06%? that's incredibly low. Where did you get the non response rate for dutasteride?

 

[xRedStaRx]

.06%? that's incredibly low. Where did you get the non response rate for dutasteride?

0.6% not 0.06%.

From the recent Dutasteride trial on Korean men.

I'm assuming the non-responsive rate was closet to 1-2% for caucasians though.

http://www.gsk-clinicalstudyregister.com/files/114264/1597/114264-Clinical-Study-Result-Summary.pdf

 

[Carlos Marcello]

Not 'a lot'. Finasteride had a non-responsive rate of around 10%, against Dutasteride's 0.6%.

But even then, the 'non-responsive rate' is measured as being below baseline. It still slows down the hair loss progression significantly. It's safe to say that if 1mg/day of finasteride does not work for you after 12 month, then Dutasteride remains a second option. Minoxidil is better at hair growth than both of them. So any stack with minoxidil should improve your results greatly at best, and nullify the non-responsive rate of finasteride at worst.

Dutasteride is the method of chemical castration for me..I had caused too much sexual sides in me..Finasteride has slightly less side effects than dutasteride.

But for some people, finasteride can work with zero side effects. Every person's metabolism is different.

Minoxidil works greatly for me, but its usage is very troublesome. Hair growth only starts when I use minoxidil twice a day..Not a once a day..I have to use it twice a day..

I don't know what I should do..

I can't use anti androgen because of scary sides..

 

[yourworld001]

Some guy over on hairlosshelp was taking 20mg a day of Finasteride, it worked for him. Can't find the thread though

 

[InvaderZim]

50 mg finasteride is pretty safe, compared to oral spironolactone, estradiol, medroxyprogesterone, etc.