@hemingway_the_mercenary @Ein @Maave @Georgie current status: agressive hairloss since 14, now 17, diffuse thinning, eyebrow hairloss, and now temples are starting to recede
current regimen: dutasteride 0.5mg ED, minoxidil 7%, Raloxifene 120mg ED, Anastrozole 1mg EOD
(I still have puffy nipples from 30mg/ml topical estradiol and I am trying to reverse it)
plan: Use Bicalutamide 100mg ED with 180mg Raloxifene ED for 10 days then Bicalutamide 50mg ED with 120mg Raloxifene ED after (currently AI dose: 1mg Anastrozole EOD)
considerations: upping my Anastrozole dose or switching to Letrozole as an AI, SARMs such as ligandrol to gain muscle, use topical estradiol to reduce testosterone levels to around 500ng/dl, get blood tested for testosterone levels
goals: stop my male pattern baldness and only feminization I want is reduced body hair (not complete feminization)
information: Bicalutamide has been proven time and time again to be more effective than oral spironolactone, cyproterone, and flutamide. "At steady-state, relative to the normal adult male range for testosterone levels (300–1,000 ng/dL),[42] circulating concentrations of bicalutamide at 50 mg/day are roughly 600 to 2,500 times higher and at 150 mg/day around 1,500 to 8,000 times higher than circulating testosterone levels, while bicalutamide concentrations." Additionally "concentrations of bicalutamide (1,000- to 10,000-fold excess) are able to completely prevent activation of the AR by androgens like DHT and testosterone and subsequent upregulation of the transcription of androgen-responsive genes and associated effects"
We know that male pattern baldness is caused by a higher # of androgen receptors in scalp hair follicles (genetics) that have a greater ability to interact with androgens such as testosterone and DHT which have a greater ability to interact with the androgen receptor. Over time the androgen receptors upregulate and male pattern baldness becomes more aggressive with aging or when someone uses an 5alpha reductase inhibitor.
My testosterone level was 1130ng/dl and my LH was borderline high as well. I am still waiting for my estradiol results on my blood test, and I will have my Bicalutamide within 2 weeks from now. To prevent AR upregulation 50mg Bica will be effective for people with <500ng/dl, 100mg Bica will be effective for people with <1000ng/dl, and 150mg Bica will be effective with <1500ng/dl.
With AR upregulation and AR activation completely inhibited, I'm convinced oral bicalutamide is basically a hair loss cure as long as the individual is using the right dose.
Dangers: 40% chance of gynecomastia with 50mg Bicalutamide and 80% chance of gynecomastia with +100mg Bicalutamide.
However, in a study done with 150mg Bicalutamide ED, tamoxifen 20mg ED reduced gynecomastia to 8.8%.
raloxifine 60mg=tamoxifene 20mg BTW
current regimen: dutasteride 0.5mg ED, minoxidil 7%, Raloxifene 120mg ED, Anastrozole 1mg EOD
(I still have puffy nipples from 30mg/ml topical estradiol and I am trying to reverse it)
plan: Use Bicalutamide 100mg ED with 180mg Raloxifene ED for 10 days then Bicalutamide 50mg ED with 120mg Raloxifene ED after (currently AI dose: 1mg Anastrozole EOD)
considerations: upping my Anastrozole dose or switching to Letrozole as an AI, SARMs such as ligandrol to gain muscle, use topical estradiol to reduce testosterone levels to around 500ng/dl, get blood tested for testosterone levels
goals: stop my male pattern baldness and only feminization I want is reduced body hair (not complete feminization)
information: Bicalutamide has been proven time and time again to be more effective than oral spironolactone, cyproterone, and flutamide. "At steady-state, relative to the normal adult male range for testosterone levels (300–1,000 ng/dL),[42] circulating concentrations of bicalutamide at 50 mg/day are roughly 600 to 2,500 times higher and at 150 mg/day around 1,500 to 8,000 times higher than circulating testosterone levels, while bicalutamide concentrations." Additionally "concentrations of bicalutamide (1,000- to 10,000-fold excess) are able to completely prevent activation of the AR by androgens like DHT and testosterone and subsequent upregulation of the transcription of androgen-responsive genes and associated effects"
We know that male pattern baldness is caused by a higher # of androgen receptors in scalp hair follicles (genetics) that have a greater ability to interact with androgens such as testosterone and DHT which have a greater ability to interact with the androgen receptor. Over time the androgen receptors upregulate and male pattern baldness becomes more aggressive with aging or when someone uses an 5alpha reductase inhibitor.
My testosterone level was 1130ng/dl and my LH was borderline high as well. I am still waiting for my estradiol results on my blood test, and I will have my Bicalutamide within 2 weeks from now. To prevent AR upregulation 50mg Bica will be effective for people with <500ng/dl, 100mg Bica will be effective for people with <1000ng/dl, and 150mg Bica will be effective with <1500ng/dl.
With AR upregulation and AR activation completely inhibited, I'm convinced oral bicalutamide is basically a hair loss cure as long as the individual is using the right dose.
Dangers: 40% chance of gynecomastia with 50mg Bicalutamide and 80% chance of gynecomastia with +100mg Bicalutamide.
However, in a study done with 150mg Bicalutamide ED, tamoxifen 20mg ED reduced gynecomastia to 8.8%.
raloxifine 60mg=tamoxifene 20mg BTW
