Oral Magnesium-threonate for DKK1 inhibition

[FollicleGuardian]

What’s your guys thoughts on inhibiting DKK1 with oral Mag.threonate? Topically it supposedly is synthesized quickly into L-ascorbate. But how about orally?

 

[whatevr]

I tried. It didn't seem to do anything orally, however...

I used/use liposomal magnesium ascorbyl phosphate (stable Vitamin C form which should metabolize into L-threonate and inhibit DKK1). It's one of the few non-AA things that I saw some results with for a while, but my hair loss eventually overpowered it.

Overall I think DKK1 is a small part of the picture, maybe 5-10%, that's why you can't stop your hair loss just with that.

Maybe you could try megadosing Vitamin C orally for a while. It would help both as an antioxidant (and Androgenetic Alopecia implies oxidative stress via ROS and TGF-b, this further increases the amount of androgens via recycling), as well some would make it to the hair follicle and inhibit DKK-1 certainly.

 

[LouisSarkozy]

what product did you use? i can't find liposomal map thanks

 

[whatevr]

Made it myself. Super-easy. Buy some MAP, phosphatidylcholine, magnetic stirrer and an ultrasonic cleaner.

Dissolve MAP in distilled water, dissolve PDC in ethanol. Mix together in magnetic stirrer. Then sonicate at 30-40°c for 30 minutes.

It's a bit of a procedure, but that's how I did it.

 

[Norwood-null-by-2021]

I tried. It didn't seem to do anything orally, however...

I used/use liposomal magnesium ascorbyl phosphate (stable Vitamin C form which should metabolize into L-threonate and inhibit DKK1). It's one of the few non-AA things that I saw some results with for a while, but my hair loss eventually overpowered it.

Overall I think DKK1 is a small part of the picture, maybe 5-10%, that's why you can't stop your hair loss just with that.

Maybe you could try megadosing Vitamin C orally for a while. It would help both as an antioxidant (and Androgenetic Alopecia implies oxidative stress via ROS and TGF-b, this further increases the amount of androgens via recycling), as well some would make it to the hair follicle and inhibit DKK-1 certainly.

What is non-AA-things?
Did you have new hair? Or what do you mean by success?
And how exactly did you use it?

 

[whatevr]

What is non-AA-things?
Did you have new hair? Or what do you mean by success?
And how exactly did you use it?

Non-antiandrogens. Anything that acts via mechanisms other than anti-androgenic.

I had regrowth of some hairs that died most recently, and maintenance for a good few months. But eventually, I started losing hair again. I used it topically at 1%.

By the way, are you from the German hair loss forum?

 

[Norwood-null-by-2021]

By the way, are you from the German hair loss forum?

Yes. Do you know me?

 

[whatevr]

Yes. Do you know me?

We haven't spoken, but I am a lurker there and remember your username. 2021 is coming fast so you are quite optimistic