OTHER enzymes in the pilosebaceous unit & skin that cause hair loss

[AnteUp]

Aside from 5 alpha reductase I, II, III which produces DHT, there are other enzymes that are involved in androgen driven hair loss. The ones I am talking about are 17 beta HSD, 3 alpha HSD, and 3 beta HSD. These are also found in male genitalia and the adrenals. Inhibiting steroidgenesis is ideal to decrease the amount of androgens produce, even though cortisol and estrogen may also be lowered.

Information is in this book http://books.google.com/books?id=0ue...page&q&f=false Do a search for HSD

Ketoconazole can inhibit steroidgenseis in the adrenals and testis. For sure it inhibits 17,20 lyase and cholesterol to testosterone. As for 17 beta HSD and 3 beta HSD there is no clear answer. Shampoo wise, it only inhibits yeast. As a topical solution, it can inhibit androgen production and promote growth. http://www.netwidesales.com/pd...etoconazole.pdf


Indomethacin is a 3 alpha HSD inhibitor. This is important as 3 alpha HSD can convert androgens directly to DHT. Also, the other benefits of cox 1 & 2 inhibitor, crth2 competitive agonist=slight pgd2 inhibition.

Trilostane is a 3 beta HSD inhibitor. Used in cushing's syndrome in animals.

Type 2,3, and 5 of 17 beta HSD are bad for hair. I need some help finding a good 17 beta HSD inhibitor that can be purchased. I only found information that can be used topically regarding type 5 inhibitors which are phytoestrogens/flavones: http://www.dcs.gla.ac.uk/~rb10...5Inhibition.pdf


Making a topical to inhibit these enzymes I believe is crucial to help stopping Androgenetic Alopecia.

I am looking for some help in creating a 17 beta HSD inhibitor, ketoconazole, indomethacin, and Trilostane topical. Unfortunately, ketoconazole is the only item available( tablets, capsules) I can find. Some help needed.

 

[AnteUp]

These “Other” enzymes are the key to hair loss and hair generation. Take a look at these figures, look closely.

http://www.nature.com/srep/2013/130325/srep01528/full/srep01528.html#f1
http://www.frontiersin.org/files/Articles/21348/fphar-03-00034-HTML/image_m/fphar-03-00034-g001.jpg



Hopefully things are making morse sense about Androgenetic Alopecia. The whole family of AKR1C(1,2,3,4) are called aldo keto reductase. They are involed with 3 alpha HSD and other HSDs. These enzymes for some reason are lacking, deficient, or inhibited. This is why there is an increase in DHT in the follicles causing hair loss. Also, PGD2 will be ELEVATED! How? Take a look again at the figures. DHT is not being converted to 3 alpha/beta diol and PGH2 is being converted to PGD2 which ultimately causes apoptosis. This is due to the problems with the AKR1C family.



This is some more information on the AKR1C family involving the prostate:
http://www.aacrmeetingabstracts.org/cgi/content/abstract/2006/1/99

And this article shows how 3 alpha HSD and ARK1C2 are involved with DHT:

http://www.ncbi.nlm.nih.gov/pubmed/18252781

We should research and look into how we can fix the AKR1C family in order to solve the DHT and PGD2 problem.


One idea is to start taking adipose from our abdominal area and injecting it into our scalp. It is high in AKR1C1/2 and 3 alpha/beta HSD and we need preadipocytes for hair follicle generation:

http://www.ncbi.nlm.nih.gov/pubmed/17170221

I know my original post is confusing. 3 alpha/beta HSD can have a reverse reaction causing an increase in DHT. This is something we should also look into. I only know that when NADH is increased, that is when 3 alpha HSD will convert DHT to 3 alpha or beta diol.