chore boy
Established Member
- Reaction score
- 1
Just a little something I'm marinating on...
p53 appears essential in chemotherapy-induced hair loss. Radiation, which also produces hair loss, is a known ROS-generating stressor... oxidative stress can trigger senescence... p53 is expressed by cells senescent cells and when inhibitors of p53 are introduced, senescent cells (fibroblasts) resume proliferation. I have to wonder if non-balding follicles found in cancer patients are able to balance back out the spike in p53 that accompanied their anti-cancer treatment (and come out of senescence) explaining why they can regrow hair where maybe Androgenetic Alopecia follicles can't overcome the p53? Maybe the oxidative stress is keeping the p53 levels elevated and that's what is keeping our cells in senescence?
Opinions?
http://en.scientificcommons.org/22644151
http://cancerres.aacrjournals.org/cgi/c ... 60/18/5002
http://ajpregu.physiology.org/cgi/repri ... 2006v1.pdf
p53 appears essential in chemotherapy-induced hair loss. Radiation, which also produces hair loss, is a known ROS-generating stressor... oxidative stress can trigger senescence... p53 is expressed by cells senescent cells and when inhibitors of p53 are introduced, senescent cells (fibroblasts) resume proliferation. I have to wonder if non-balding follicles found in cancer patients are able to balance back out the spike in p53 that accompanied their anti-cancer treatment (and come out of senescence) explaining why they can regrow hair where maybe Androgenetic Alopecia follicles can't overcome the p53? Maybe the oxidative stress is keeping the p53 levels elevated and that's what is keeping our cells in senescence?
Opinions?
http://en.scientificcommons.org/22644151
http://cancerres.aacrjournals.org/cgi/c ... 60/18/5002
http://ajpregu.physiology.org/cgi/repri ... 2006v1.pdf